dc.creator | Tabares, Lucía | es |
dc.creator | Alés González de la Higuera, Eva María | es |
dc.creator | Lindau, Manfred | es |
dc.creator | Álvarez de Toledo Naranjo, Guillermo | es |
dc.date.accessioned | 2023-05-17T12:56:10Z | |
dc.date.available | 2023-05-17T12:56:10Z | |
dc.date.issued | 2001-08-27 | |
dc.identifier.citation | Tabares, L., Alés González de la Higuera, E.M., Lindau, M. y Álvarez de Toledo Naranjo, G. (2001). Exocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 276 (43), 39974-39979. https://doi.org/10.1074/jbc.M106498200. | |
dc.identifier.issn | 0021-9258 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146247 | |
dc.description.abstract | Recent evidence suggests that endocytosis in neuroendocrine cells and neurons can be tightly coupled to
exocytosis, allowing rapid retrieval from the plasma
membrane of fused vesicles for future use. This can be a
much faster mechanism for membrane recycling than
classical clathrin-mediated endocytosis. During a fast
exo-endocytotic cycle, the vesicle membrane does not
fully collapse into the plasma membrane; nevertheless,
it releases the vesicular contents through the fusion
pore. Once the vesicle is depleted of transmitter, its
membrane is recovered without renouncing its identity.
In this report, we show that chromaffin cells contain
catecholamine-free granules that retain their ability to
fuse with the plasma membrane. These catecholaminefree granules represent 7% of the total population of
fused vesicles, but they contributed to 47% of the fusion
events when the cells were treated with reserpine for
several hours. We propose that rat chromaffin granules
that transiently fuse with the plasma membrane preserve their exocytotic machinery, allowing another
round of exocytosis. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 p. | es |
dc.language.iso | eng | es |
dc.publisher | Science Direct | es |
dc.relation.ispartof | JOURNAL OF BIOLOGICAL CHEMISTRY, 276 (43), 39974-39979. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Exocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0021925820600692?via%3Dihub | es |
dc.identifier.doi | 10.1074/jbc.M106498200 | es |
dc.journaltitle | JOURNAL OF BIOLOGICAL CHEMISTRY | es |
dc.publication.volumen | 276 | es |
dc.publication.issue | 43 | es |
dc.publication.initialPage | 39974 | es |
dc.publication.endPage | 39979 | es |