NameTabares, Lucía
DepartmentFisiología Médica y Biofísica
Knowledge areaFisiología
Professional categoryCatedrática de Universidad
E-mailRequest
           
  • No. publications

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SMN Is Physiologically Downregulated at Wild-Type Motor Nerve Terminals but Aggregates Together with Neurofilaments in SMA Mouse Models

Franco Espín, Julio; Gatius, Alaó; Armengol, José Ángel; Arumugam, Saravanan; Moradi, Mehri; Sendtner, Michael; Calderó, Jordi; Tabares, Lucía (MDPI, 2022)
muscular atrophy (SMA). SMN forms the core of a protein complex localized at the cytoplasm and nuclear gems and that ...
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Editorial: Molecular Nanomachines of the Presynaptic Terminal, Volume II

Tabares, Lucía; Rizzoli, Silvio O. (Frontiers Research Foundation, 2022)
The synapse has been designed and refined during animal evolution for two main processes: (1) to translate and transmit ...
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Functional regeneration of the murine neuromuscular synapse relies on long‑lasting morphological adaptations

Bermedo García, Francisca; Zelada, Diego; Martínez, Esperanza; Tabares, Lucía; Henríquez, Juan Pablo (BMC, 2022)
Background: In a broad variety of species, muscle contraction is controlled at the neuromuscular junction (NMJ), the ...
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Presynaptic Mitochondria Communicate With Release Sites for Spatio-Temporal Regulation of Exocytosis at the Motor Nerve Terminal

López Manzaneda, Mario; Fuentes Moliz, Andrea; Tabares, Lucía (Frontiers Research Foundation, 2022)
Presynaptic Ca2+ regulation is critical for accurate neurotransmitter release, vesicle reloading of release sites, and ...
PhD Thesis
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Papel de la proteína de supervivencia de la motoneurona (SMN) en la maduración sináptica

Franco Espín, Julio; Tabares, Lucía (2021)
La atrofia muscular espinal (AME), la causa genética más frecuente de mortalidad infantil, es una enfermedad neurodegenerativa ...
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Calcium is reduced in presynaptic mitochondria of motor nerve terminals during neurotransmission in SMA mice

López Manzaneda, Mario; Franco Espín, Julio; Tejero Navarro, Rocío; Cano, Raquel; Tabares, Lucía (Oxford University Press, 2021)
Spinal muscular atrophy (SMA) is an autosomal recessive degenerative motor neuron disease characterized by symmetrical ...
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R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy

Tejero, Rocío; Balk, Stefanie; Franco-Espin, Julio; Ojeda Orellana, Jorge; Hennlein, Luisa; Drexl, Hans; Tabares, Lucía; Jablonka, Sibylle;  (Elsevier, 2020)
Neurotransmission defects and motoneuron degeneration are hallmarks of spinal muscular atrophy, a monogenetic disease ...
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The mouse levator auris longus muscle: an amenable model system to study the role of postsynaptic proteins to the maintenance and regeneration of the neuromuscular synapse

Ojeda, Jorge; Bermedo-García, Francisca; Pérez, Viviana; Mella, Jessica; Hanna, Patricia; Herzberg, Daniel; Tejero, Rocío; López Manzaneda, Mario; Tabares, Lucía; Henríquez, Juan Pablo (Frontiers Media S.A., 2020)
The neuromuscular junction (NMJ) is the peripheral synapse that controls the coordinated movement of many organisms. The ...
PhD Thesis
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Estudio del calcio mitocondrial en terminales nerviosos motores y su relación en el proceso de neurotransmisión. Alteraciones en la atrofia muscular espinal

López Manzaneda, Mario; Tabares, Lucía (2019)
La mitocondria es uno de los principales moduladores de los niveles de calcio citosólico además de la principal fuente de ...
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BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle

Delezie, Julien; Weihrauch, Martin; Maier, Geraldine; Tejero, Rocío; Ham, Daniel J.; Gill, Jonathan F.; Tabares, Lucía; Handschin, Christoph (NATL ACAD SCIENCES, 2019)
Brain-derived neurotrophic factor (BDNF) influences the differentiation, plasticity, and survival of central neurons and ...
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HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System

Bachiller, Sara; Roca Ceballos, María Angustias; García Domínguez, Irene; Pérez Villegas, Eva María; Martos Carmona, David; Pérez Castro, Miguel Ángel; Real Navarrete, Luis Miguel; Rosa, José Luis; Tabares, Lucía; Venero Recio, José Luis; Armengol, José Ángel; Carrión, Ángel Manuel; Ruiz Laza, Rocío (Springer, 2018)
A missense mutation in HERC1 provokes loss of cerebellar Purkinje cells, tremor, and unstable gait in tambaleante (tbl) ...
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Smn-Deficiency Increases the Intrinsic Excitability of Motoneurons

Arumugam, Saravanan; Garcera, Ana; Soler, Rosa M.; Tabares, Lucía (2017)
During development, motoneurons experience significant changes in their size and in the number and strength of connections ...
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CSPα, a molecular co-chaperone essential for short and long-term synaptic maintenance

López Ortega, Elena; Ruiz Laza, Rocío; Tabares, Lucía;  (Frontiers Media S.A., 2017)
Cysteine string protein a (CSPα) is a vesicle protein located in the presynaptic terminal of most synapses. CSPα is an ...
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Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction

Bertone, Nicolas Ivan; Groisman, Ayelén Ivana; Mazzone, Graciela Lujan; Cano, Raquel; Tabares, Lucía; Uchitel, Osvaldo Daniel (Wiley, 2017)
Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic ...
PhD Thesis
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Identificación de componentes moleculares sinápticos que contribuyen a la vulnerabilidad de los terminales nerviosos motores en un modelo múrido de atrofia muscular espinal

Tejero Navarro, Rocío; Tabares, Lucía (2016)
La Atrofia Muscular Espinal (AME), la causa genética más frecuente de mortalidad infantil, es una enfermedad neurodegenerativa ...
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The Active and Periactive Zone Organization and the Functional Properties of Small and Large Synapses

Cano, Raquel; Tabares, Lucía (2016)
The arrival of an action potential (AP) at a synaptic terminal elicits highly synchronized quanta release. Repetitive APs ...
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Editorial: Molecular nanomachines of the presynaptic terminal

Rizzoli, Silvio O.; Tabares, Lucía (Frontiers Research Foundation, 2016)
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Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy

Tejero, Rocío; López Manzaneda, Mario; Arumugam, Saravanan; Tabares, Lucía (OXFORD UNIV PRESS, 2016)
Spinal muscular atrophy (SMA) is the most frequent genetic cause of infant mortality. The disease is characterized ...
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Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions

Wu, Yuan Ju; Tejero, Rocío; Arancillo, Marife; Vardar, Gülcin; Korotkova, Tatiana; Kintscher, Michael; Tabares, Lucía; Rosenmund, Christian (AMER PHYSIOLOGICAL SOC, 2015)
Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions. ...
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Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1 alpha

Arnold, Anne Sophie; Gill, Jonathan; Christe, Martine; Ruiz Laza, Rocío; McGuirk, Shawn; St-Pierre, Julie; Tabares, Lucía; Handschin, Christoph (NATURE PUBLISHING GROUP, 2014)
The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In the mature muscle, the relative ...
PhD Thesis
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Different Modes of Synaptic Vesicle Recycling un Synaptophysin-pHluorin Transgenic Mouse Motor Nerve Terminals

Cano García, Raquel; Tabares, Lucía (2014)
In the present work, a new tool for studying synaptic vesicle exo- and end ... The adult vertebrate NMJ is a highly reliable ...
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Fast motor axon loss in SMARD1 does not correspond to morphological and functional alterations of the NMJ

Krieger, Frank; Elflein, Nicole; Ruiz Laza, Rocío; Guerra, Joana; Serrano, Antonio L.; Asan, Esther; Tabares, Lucía; Jablonka, Sibylle (Elsevier, 2013)
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a childhood motoneuron disease caused by mutations ...
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Notch Signaling Pathway Is Activated in Motoneurons of Spinal Muscular Atrophy

Lladó, Jerònia; Caraballo Miralles, Víctor; Tabares, Lucía; Torres Benito, Laura; Cardona Rossinyol, Andrea; Olmos, Gabriel; Garcera, Ana; Solar, Rosa María (2013)
PhD Thesis
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Función de la proteína de supervivencia de motoneuronas (SMN) en la maduración funcional y organización sináptica en un modelo murino de atrofia muscular espinal

Torres Benito, Laura; Tabares, Lucía (2012)
La Atrofia Muscular Espinal (AME) es una enfermedad autosómica recesiva caracterizada por debilidad muscular y deterioro ...
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SMN Requirement for Synaptic Vesicle, Active Zone and Microtubule Postnatal Organization in Motor Nerve Terminals

Torres Benito, Laura; Feodora Neher, Margret; Cano, Raquel; Tabares, Lucía (2011)
Low levels of the Survival Motor Neuron (SMN) protein produce Spinal Muscular Atrophy (SMA), a severe monogenetic disease ...
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Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse

Ruiz Laza, Rocío; Cano, Raquel; Casañas, Juan José; Gaffield, Michael A.; Betz, William J.; Tabares, Lucía (SOC NEUROSCIENCE, 2011)
Synchronous neurotransmitter releaseis a highly regulated processthattakes place at specializations atthe presynapticmembrane ...
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Synaptic defects in spinal muscular atrophy animal models

Torres-Benito, Laura; Ruiz Laza, Rocío; Tabares, Lucía (Wiley, 2011)
Proximal spinal muscular atrophy, the most frequent genetic cause of childhood lethality, is caused by homozygous loss or ...
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Multiple Functions of the Vesicular Proton Pump in Nerve Terminals

Tabares, Lucía; Betz, Bill (Cell Press, 2010)
Synaptic vesicles are acidified by a proton pump (vATPase), which allows vesicular uptake of neurotransmitters. After ...
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Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice

Ruiz Laza, Rocío; Casañas, Juan José; Torres-Benito, Laura; Cano, Raquel; Tabares, Lucía (SOC NEUROSCIENCE, 2010)
Low levels of survival motor neuron (SMN) protein result in spinal muscular atrophy (SMA), a severe genetic disease ...
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Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy

Simon, Christian M.; Jablonka, Sibylle; Ruiz Laza, Rocío; Tabares, Lucía; Sendtner, Michael (OXFORD UNIV PRESS, 2010)
Proximal spinal muscular atrophy (SMA) is caused by homozygous loss or mutation of the SMN1 gene on human chromosome 5. ...
PhD Thesis
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Monitorización de la función sináptica normal y patológica en modelos animales

Ruiz Laza, Rocío; Tabares, Lucía (2009)
El objetivo principal de esta Tesis Doctoral ha sido el estudio de la transmisión sináptica en la unión neuromuscular. El ...
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The spatial pattern of exocytosis and post-exocytic mobility of synaptopHluorin in mouse motor nerve terminals

Gaffield, Michael A.; Tabares, Lucía; Betz, William J. (Wiley, 2009)
We monitored the spatial distribution of exo- and endocytosis at 37◦C in mouse motor nerve terminals expressing synaptopHluorin ...
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Preferred Sites of Exocytosis and Endocytosis Colocalize during High- But Not Lower-Frequency Stimulation in Mouse Motor Nerve Terminals

Gaffield, Michael A.; Tabares, Lucía; Betz, William J. (SOC NEUROSCIENCE, 2009)
The spatial relationship of exocytosis and endocytosis in motor nerve terminals has been explored, with varied results, ...
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Cysteine string protein-α is essential for the high calciumsensitivity of exocytosis in a vertebrate synapse

Ruiz Laza, Rocío; Casañas, J. J.; Südhof, T. C.; Tabares, Lucía (Wiley, 2008)
Cysteine string protein (CSPa) is a synaptic vesicle protein present in most central and peripheral nervous system ...
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Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration

Cabanes, Carmen; Bonilla, Sonia; Tabares, Lucía; Martínez, Salvador (2007)
Degenerative spinal motor diseases, like amyotrophic lateral sclerosis, are produced by progressive degeneration of motoneurons. ...
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Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration

Cabanes, Carmen; Bonilla, Sonia; Tabares, Lucía; Martínez, Salvador (2007)
Degenerative spinal motor diseases, like amyotrophic lateral sclerosis, are produced by progressive degeneration of ...
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Monitoring synaptic function at the neuromuscular junction of a mouse expressing synaptopHluorin

Tabares, Lucía; Ruiz Laza, Rocío; Linares Clemente, Pedro; Gaffield, Michael A.; Álvarez de Toledo Naranjo, Guillermo; Fernández-Chacón, Rafael; Betz, William J. (2007)
We monitored presynaptic exocytosis and vesicle recycling at neuromuscular junctions of transgenic mice expressing ...
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CSP alpha-deficiency causes massive and rapid photoreceptor degeneration

Schmitz, Frank; Tabares, Lucía; Khimich, Darina; Strenzke, Nicola; Villa Polo, Pedro de la; Castellano Muñoz, Manuel; Bulankina, Anna; Moser, Tobias; Fernández-Chacón, Rafael; Südhof, Thomas C. (2006)
Cysteine string protein (CSP) _ is an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of ...
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Treatment with trkC agonist antibodies delays disease progression in neuromuscular degeneration (nmd) mice

Ruiz Laza, Rocío; Lin, J.; Forgie, A.; Foletti, D.; Shelton, D.; Rosenthal, A.; Tabares, Lucía (OXFORD UNIV PRESS, 2005)
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a fatal autosomal recessive disorder seen in infants. ...
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The synaptic vesicle protein CSP alpha prevents presynaptic degeneration

Fernández-Chacón, Rafael; Wolfel, M.; Nishimune, H.; Tabares, Lucía; Schmitz, Frank; Castellano-Munoz, M.; Rosenmund, Christian; Montesinos Gutiérrez, María Luz; Sudhof, TC (CELL PRESS, 2004)
Cysteine string protein α (CSPα)—an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40 ...
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Exocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells

Tabares, Lucía; Alés González de la Higuera, Eva María; Lindau, Manfred; Álvarez de Toledo Naranjo, Guillermo (Science Direct, 2001)
Recent evidence suggests that endocytosis in neuroendocrine cells and neurons can be tightly coupled to exocytosis, allowing ...
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Dopamine induces intracellular Ca2+ signals mediated by alpha(1B)-adrenoceptors in rat pineal cells

Rey, Elkin; Hernández-Díaz, Francisco J.; Abreu, Pedro; Alonso, Rafael; Tabares, Lucía (ELSEVIER SCIENCE BV, 2001)
We have studied the functional interaction of dopamine with a -adrenoceptor subtypes by measuring intracellular Ca2q 1 ...
PhD Thesis
PhD Thesis
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Estudio de la señal de calcio y las corrientes iónicas en el acoplamiento entre el estímulo y la secreción en células pineales en la rata

Marín Caballos, Antonio Jesús; Tabares, Lucía (1995)
Se han empleado distintas técnicas para estudiar los mecanismos implicados en las diferentes etapas del proceso de ...
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Properties of Calcium and Potassium Currents of Clonal Adrenocortical Cells

López Barneo, José; Tabares, Lucía; Ureña López, Juan (1989)
The ionic currents of clonal Y-1 adrenocortical cells were studied using the whole-cell variant of the patch-clamp technique. ...
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Effects of membrane depolarization and divalent-cations on anaphylactic histamine secretion

Pintado, E.; Dorado, M.E.; Tabares, Lucía; López Barneo, José (1986)
The effects of membrane depolariz.ation and divalent cations on histamine release have been studied in sensitized mast ...
PhD Thesis
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Electrofisiología de células adrenocorticales: Estudio mediante el registro intracelular y la técnica de “patch clamp”

Tabares, Lucía; López Barneo, José (1985)
El presente trabajo se centra en el estudio de las características electrofisiológicas de células adrenocorticales en ...