Artículo
Metabolomic research on the role of interleukin-4 in Alzheimer’s disease
Autor/es | González Domínguez, Raúl
García Barrera, Tamara Vitorica Ferrández, Francisco Javier Gómez Ariza, José Luis |
Departamento | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal |
Fecha de publicación | 2015 |
Fecha de depósito | 2022-11-11 |
Publicado en |
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Resumen | Inflammation plays a prominent role in the pathogenesis of Alzheimer’s disease, affecting both brain and the peripheral system. Thus, modulation of inflammation in animal models of this neurodegenerative disorder may be ... Inflammation plays a prominent role in the pathogenesis of Alzheimer’s disease, affecting both brain and the peripheral system. Thus, modulation of inflammation in animal models of this neurodegenerative disorder may be of great interest to elucidate the pathological mechanisms underlying this inflammatory component. To this end, a metabolomic investigation on a triple transgenic mouse model obtained by crossing the APP/PS1 mice with interleukin-4 knockout mice (a model of impaired immune function) was performed for the first time. Serum samples from transgenic mice and wild type animals were analyzed by direct infusion mass spectrometry followed by multivariate statistics in order to identify altered metabolites. Subsequently, metabolic pathway analysis allowed the elucidation of potential pathological mechanisms associated with the development of Alzheimer-type disorders in response to interleukin-4 deficiency, such as impaired homeostasis of histamine, altered metabolism of amino acids (threonine, aspartate and tyrosine), deregulated urea cycle and increased production of eicosanoids. Therefore, this work demonstrates the potential of this triple transgenic model with modulated immunity for the study of pathological mechanisms associated with inflammation in Alzheimer’s disease. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España Junta de Andalucía |
Identificador del proyecto | CTM2012-38720-C03-01
P009-FQM-4659 P012-FQM-0442 |
Cita | González Domínguez, R., García Barrera, T., Vitorica Ferrández, F.J. y Gómez Ariza, J.L. (2015). Metabolomic research on the role of interleukin-4 in Alzheimer’s disease. Metabolomics, 11 (5), 1175-1183. https://doi.org/10.1007/s11306-015-0773-z. |
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