dc.creator | González Domínguez, Raúl | es |
dc.creator | García Barrera, Tamara | es |
dc.creator | Vitorica Ferrández, Francisco Javier | es |
dc.creator | Gómez Ariza, José Luis | es |
dc.date.accessioned | 2022-11-11T11:37:10Z | |
dc.date.available | 2022-11-11T11:37:10Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | González Domínguez, R., García Barrera, T., Vitorica Ferrández, F.J. y Gómez Ariza, J.L. (2015). Metabolomic research on the role of interleukin-4 in Alzheimer’s disease. Metabolomics, 11 (5), 1175-1183. https://doi.org/10.1007/s11306-015-0773-z. | |
dc.identifier.issn | 1573-3882 | es |
dc.identifier.uri | https://hdl.handle.net/11441/139311 | |
dc.description.abstract | Inflammation plays a prominent role in the pathogenesis of Alzheimer’s disease, affecting both brain and the peripheral system. Thus, modulation of inflammation in animal models of this neurodegenerative disorder may be of great interest to elucidate the pathological mechanisms underlying this inflammatory component. To this end, a metabolomic investigation on a triple transgenic mouse model obtained by crossing the APP/PS1 mice with interleukin-4 knockout mice (a model of impaired immune function) was performed for the first time. Serum samples from transgenic mice and wild type animals were analyzed by direct infusion mass spectrometry followed by multivariate statistics in order to identify altered metabolites. Subsequently, metabolic pathway analysis allowed the elucidation of potential pathological mechanisms associated with the development of Alzheimer-type disorders in response to interleukin-4 deficiency, such as impaired homeostasis of histamine, altered metabolism of amino acids (threonine, aspartate and tyrosine), deregulated urea cycle and increased production of eicosanoids. Therefore, this work demonstrates the potential of this triple transgenic model with modulated immunity for the study of pathological mechanisms associated with inflammation in Alzheimer’s disease. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación CTM2012-38720-C03-01 | es |
dc.description.sponsorship | Junta de Andalucía Consejería de Innovación, Ciencia y Empresa P012-FQM-0442 and P009-FQM-4659 | es |
dc.format | application/pdf | es |
dc.format.extent | 8 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer | es |
dc.relation.ispartof | Metabolomics, 11 (5), 1175-1183. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Metabolomics APP/PS1 mice | es |
dc.subject | Interleukin4 | es |
dc.subject | Direct infusion mass spectrometry | es |
dc.subject | Alzheimer’s disease | es |
dc.title | Metabolomic research on the role of interleukin-4 in Alzheimer’s disease | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal | es |
dc.relation.projectID | CTM2012-38720-C03-01 | es |
dc.relation.projectID | P009-FQM-4659 | es |
dc.relation.projectID | P012-FQM-0442 | es |
dc.relation.publisherversion | https://doi.org/10.1007/s11306-015-0773-z | es |
dc.identifier.doi | 10.1007/s11306-015-0773-z | es |
dc.journaltitle | Metabolomics | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 1175 | es |
dc.publication.endPage | 1183 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Junta de Andalucía | es |