idUS - Author profile: Vitorica Ferrández, Francisco Javier

Name	Vitorica Ferrández, Francisco Javier
Department	Bioquímica y Biología Molecular
Knowledge area	Bioquímica y Biología Molecular
Professional category	Catedrático de Universidad
E-mail	Request

No. publications
56
No. visits
7603
No. downloads
13753

Typology

Sort

Publications
Article Monocyte-derived Cells Invade Brain Parenchyma and Amyloid Plaques in Human Alzheimer’s Disease Hippocampus Muñoz-Castro, Clara; Muñoz-Castro, Clara; Mejías Ortega, Marina; Mejías Ortega, Marina; Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Navarro Garrido, Victoria; Trujillo Estrada, Laura; Trujillo Estrada, Laura; Jiménez, Sebastián; Jiménez, Sebastián; García León, Juan Antonio; García León, Juan Antonio; Fernández Valenzuela, Juan José; Fernández Valenzuela, Juan José; Sánchez Mico, María Virtudes; Sánchez Mico, María Virtudes; Romero Molina, Carmen; Romero Molina, Carmen; Moreno González, Inés; Moreno González, Inés; Baglietto Vargas, David; Baglietto Vargas, David; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier (Springer Nature, 2023-01-01) Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the ...
Article Cytotoxicity and Effects on the Synapsis Induced by Pure Cylindrospermopsin in an E17 Embryonic Murine Primary Neuronal Culture in a Concentration-and Time-Dependent Manner Hinojosa, María Gracia; Hinojosa, María Gracia; Prieto Ortega, Ana Isabel; Prieto Ortega, Ana Isabel; Muñoz Castro, Clara; Muñoz Castro, Clara; Sánchez Mico, María; Sánchez Mico, María; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Cameán Fernández, Ana María; Cameán Fernández, Ana María; Jos Gallego, Ángeles Mencía; Jos Gallego, Ángeles Mencía (Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01) Cylindrospermopsin (CYN) is a cyanotoxin whose incidence has been increasing in the last decades. Due to its capacity to ...
Article Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Mejías Ortega, Marina; Mejías Ortega, Marina; Fernández Valenzuela, Juan José; Fernández Valenzuela, Juan José; Núñez Díaz, Cristina; Núñez Díaz, Cristina; Cáceres Palomo, Laura; Cáceres Palomo, Laura; Vegas Gómez, Laura; Vegas Gómez, Laura; Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Trujillo Estrada, Laura Isabel; Trujillo Estrada, Laura Isabel; García León, Juan Antonio; García León, Juan Antonio; Moreno González, Inés; Moreno González, Inés; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Baglietto Vargas, David; Baglietto Vargas, David; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia (Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01) Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease ...
Article Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease Salvadores, Natalia; Salvadores, Natalia; Moreno González, Inés; Moreno González, Inés; Gámez, Nazaret; Gámez, Nazaret; Quiroz, Gabriel; Quiroz, Gabriel; Vegas Gómez, Laura; Vegas Gómez, Laura; Escandón, Marcela; Escandón, Marcela; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia; Soto, Claudio; Soto, Claudio; Court, Felipe A.; Court, Felipe A. (BMC, 2022-01-01) Alzheimer’s disease (AD) is a major adult-onset neurodegenerative condition with no available treatment. Compelling reports ...
Article Galectin-3 is elevated in CSF and is associated with A beta deposits and tau aggregates in brain tissue in Alzheimer's disease Boza Serrano, Antonio; Boza Serrano, Antonio; Vrillon, Agathe; Vrillon, Agathe; Minta, Karolina; Minta, Karolina; Paulus, Agnes; Paulus, Agnes; Camprubí Ferrer, Lluís; Camprubí Ferrer, Lluís; García, Megg; García, Megg; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Venero Recio, José Luis; Venero Recio, José Luis; Deierborg, Tomas; Deierborg, Tomas (Springer, 2022-01-01) Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous ...
PhD Thesis Variaciones de la respuesta microglial según el contexto patológico en la Enfermedad de Alzheimer Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Romero Molina, Carmen; Romero Molina, Carmen (2021-04-30) La Enfermedad de Alzheimer (EA) es un trastorno neurodegenerativo progresivo e irreversible que conlleva un deterioro de ...
PhD Thesis Implicación de la disfunción glial en la evolución de la patología en pacientes de Alzheimer Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Muñoz Castro, Clara; Muñoz Castro, Clara (2021-01-20) La enfermedad de Alzheimer (EA) es un proceso neurodegenerativo que cursa con un deterioro progresivo de las funciones ...
Article Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Fernández Valenzuela, Juan José; Fernández Valenzuela, Juan José; Castro, Vanessa de; Castro, Vanessa de; Mejías Ortega, Marina; Mejías Ortega, Marina; Gómez Arboledas, Ángela; Gómez Arboledas, Ángela; Jiménez, Sebastián; Jiménez, Sebastián; Sánchez Mico, María; Sánchez Mico, María; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia; Gutiérrez, Antonia (Frontiers Media, 2021-01-01) Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that ...
Article Should we open fire on microglia? Depletion models as tools to elucidate microglial role in health and alzheimer’s disease Romero Molina, Carmen; Romero Molina, Carmen; Navarro Garrido, Victoria; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Muñoz Castro, Clara; Sánchez Mico, María; Sánchez Mico, María; Gutiérrez, Antonia; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa (Multidisciplinary Digital Publishing Institute (MDPI), 2021-01-01) Microglia play a critical role in both homeostasis and disease, displaying a wide variety in terms of density, functional ...
Article Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1 March Diaz, Rosana; March Diaz, Rosana; Lara Ureña, Nieves; Lara Ureña, Nieves; Romero Molina, Carmen; Romero Molina, Carmen; Heras Garvin, Antonio; Heras Garvin, Antonio; Ortega de San Luis, Clara; Ortega de San Luis, Clara; Alvarez Vergara, Maria I.; Alvarez Vergara, Maria I.; Navarro Garrido, Victoria; Navarro Garrido, Victoria; Sánchez Mico, María Victoria; Sánchez Mico, María Victoria; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; López Barneo, José; López Barneo, José; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Pascual, Alberto; Pascual, Alberto (Springer, 2021-01-01) Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), ...
Article Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases Pérez Jiménez, Mercedes María; Pérez Jiménez, Mercedes María; Monje Moreno, José Manuel; Monje Moreno, José Manuel; Brokate Llanos, Ana María; Brokate Llanos, Ana María; Venegas Calerón, Mónica; Venegas Calerón, Mónica; Sánchez García, Alicia; Sánchez García, Alicia; Sansigre, Paula; Sansigre, Paula; Valladares, Amador; Valladares, Amador; Esteban García, Sara; Esteban García, Sara; Suárez Pereira, Irene; Suárez Pereira, Irene; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Ríos, José Julián; Ríos, José Julián; Artal Sanz, Marta; Artal Sanz, Marta; Carrión, Ángel Manuel; Carrión, Ángel Manuel; Muñoz, Manuel Jesús; Muñoz, Manuel Jesús (Springer Nature, 2021-01-01) Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases ...
Article Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease García León, Juan Antonio; García León, Juan Antonio; Cáceres Palomo, Laura; Cáceres Palomo, Laura; Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Mejías Ortega, Marina; Mejías Ortega, Marina; Núñez Díaz, Cristina; Núñez Díaz, Cristina; Fernández Valenzuela, Juan José; Fernández Valenzuela, Juan José; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Dávila Cansino, José Carlos; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia; Gutiérrez, Antonia (MDPI, 2020-01-01) Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s ...
Article Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice Larramona Arcas, Raquel; Larramona Arcas, Raquel; González Arias, Candela; González Arias, Candela; Perea, Gertrudis; Perea, Gertrudis; Gutiérrez, Antonia; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; García Barrera, Tamara; García Barrera, Tamara; Gómez Ariza, José Luis; Gómez Ariza, José Luis; Pascua Maestro, Raquel; Pascua Maestro, Raquel; Ganfornina, María Dolores; Ganfornina, María Dolores; Kara, Eleanna; Kara, Eleanna; Martínez Vicente, Marta; Martínez Vicente, Marta (BMC, 2020-01-01) Background The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes ...
Article Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease Sánchez Mico, María; Sánchez Mico, María; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Gómez Arboledas, Ángela; Gómez Arboledas, Ángela; Muñoz Castro, Clara; Muñoz Castro, Clara; Romero Molina, Carmen; Romero Molina, Carmen; Navarro Garrido, Victoria; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier (Wiley, 2020-01-01) Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques ...
Article Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells García Bonilla, María; García Bonilla, María; García-Martín, María Luisa; García-Martín, María Luisa; Ojeda Pérez, Betsaida; Ojeda Pérez, Betsaida; Muñoz Hernández, Mª Carmen; Muñoz Hernández, Mª Carmen; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Cifuentes, Manuel; Cifuentes, Manuel; Santos Ruíz, Leonor; Santos Ruíz, Leonor; Shumilov, Kirill; Shumilov, Kirill; Claros, Silvia; Claros, Silvia; Páez González, Patricia; Páez González, Patricia; Jiménez, Antonio J.; Jiménez, Antonio J. (BMC, 2020-01-01) BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial ...
Article Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model Fernández Valenzuela, Juan José; Fernández Valenzuela, Juan José; Muñoz Castro, Clara; Muñoz Castro, Clara; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gutierrez Pérez, Antonia; Gutierrez Pérez, Antonia (Nature Research, 2020-01-01) In Alzheimer’s disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity ...
PhD Thesis Caracterización de la respuesta y función astroglial en modelos y pacientes de la enfermedad de Alzheimer. Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Sánchez Mico, María; Sánchez Mico, María (2019-03-25)
Article Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform García León, Juan Antonio; García León, Juan Antonio; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia (Future Science Group, 2019-01-01) Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together ...
Article Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Núñez Díaz, Cristina; Núñez Díaz, Cristina; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Gómez Arboledas, Ángela; Gómez Arboledas, Ángela; García León, Juan Antonio; García León, Juan Antonio; Fernández Valenzuela, Juan José; Fernández Valenzuela, Juan José; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia (Wiley Open Access, 2019-01-01) Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer’s ...
Article Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease Boza Serrano, Antonio; Boza Serrano, Antonio; Ruíz Laza, Rocio; Ruíz Laza, Rocio; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; García Revilla, Juan; García Revilla, Juan; Yang, Yiyi; Yang, Yiyi; Jiménez Ferrer, Itzia; Jiménez Ferrer, Itzia; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Roca Ceballos, María Angustias; Roca Ceballos, María Angustias; Navarro Garrido, Victoria; Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Venero Recio, José Luis; Venero Recio, José Luis; Deierborg, Tomas; Deierborg, Tomas (Springer, 2019-01-01) Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of ...
Article Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology Romero Molina, Carmen; Romero Molina, Carmen; Navarro Garrido, Victoria; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Fernández Valenzuela, Juan José; Fernández Valenzuela, Juan José; Sánchez Mico, María; Sánchez Mico, María; Muñoz Castro, Clara; Muñoz Castro, Clara; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa (Frontiers Media Research Foundation, 2018-11-14) Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease ...
Article Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative Navarro Garrido, Victoria; Navarro Garrido, Victoria; Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Muñoz Castro, Clara; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Dávila, José Carlos; Dávila, José Carlos; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier (Frontiers Media, 2018-01-01) Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative ...
Article Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease Gómez Arboledas, Ángela; Gómez Arboledas, Ángela; Dávila Cansino, José Carlos; Dávila Cansino, José Carlos; Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Navarro Garrido, Victoria; Núñez Díaz, Cristina; Núñez Díaz, Cristina; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Sánchez Mico, María; Sánchez Mico, María; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia (Wiley, 2018-01-01) Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation ofcomponents of intermediate ...
Final Degree Project Estrategias terapéuticas en la efermedad de alzheimer Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Riera LLull, Nieves; Riera LLull, Nieves (2017-01-01)
Article Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease Baglietto Vargas, David; Baglietto Vargas, David; Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Trujillo Estrada, Laura Isabel; Gómez Arboledas, Ángela; Gómez Arboledas, Ángela; Sánchez Mico, María; Sánchez Mico, María; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Dávila Cansino, José Carlos; Dávila Cansino, José Carlos; García Verdugo, José Manuel; García Verdugo, José Manuel; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia (Nature Research (part of Springer Nature), 2017-01-01) Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. ...
Article Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo Serrano Pozo, Alberto; Serrano Pozo, Alberto; Sánchez García, Manuel A.; Sánchez García, Manuel A.; Heras Garvín, Antonio; Heras Garvín, Antonio; March Díaz, Rosana Rocío; March Díaz, Rosana Rocío; Navarro Garrido, Victoria; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; López Barneo, José; López Barneo, José; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Pascual, Alberto; Pascual, Alberto (Public Library of Science, 2017-01-01) Background Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number ...
Article Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-β-Induced Neuronal Death Fernández, Ana M.; Fernández, Ana M.; Hervás, Rubén; Hervás, Rubén; Domínguez Fraile, Manuel; Domínguez Fraile, Manuel; Garrido Navarro, Victoria; Garrido Navarro, Victoria; Gómez Gutiérrez, Patricia; Gómez Gutiérrez, Patricia; Vega, Miguel; Vega, Miguel; Torres Alemán, Ignacio; Torres Alemán, Ignacio; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier (IOS Press, 2016-06-07) Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain ...
PhD Thesis Efectos de la acumulación del péptido Beta amiloide en tejido cerebral de ratones PS1xAPP modelos de la Enfermedad de Alzheimer Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián (2016-01-15) Esta enfermedad se ha convertido en el tercer problema de salud más grave en los países desarrollados (detrás de los ...
Article Soluble phospho‑tau from Alzheimer’s disease hippocampus drives microglial degeneration Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Sánchez Mico, María; Sánchez Mico, María; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Núñez Díaz, Cristina; Núñez Díaz, Cristina; Trujillo Estrada, Laura Isabel; Trujillo Estrada, Laura Isabel; Dávila, José Carlos; Dávila, José Carlos; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier (Springer (part of Springer Nature): Springer Open Choice Hybrid Journals, 2016-01-01) The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, ...
Article Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-βInduced Neuronal Death Navarro Garrido, Victoria; Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Fernández, Ana M.; Fernández, Ana M.; Hervasa, Rubén; Hervasa, Rubén; Gómez Gutiérrez, Patricia; Gómez Gutiérrez, Patricia; Vega, Miguel; Vega, Miguel (IOS Press, 2016-01-01) Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain ...
Article Metabolomic screening of regional brain alterations in the APP/PS1 transgenic model of Alzheimer's disease by direct infusion mass spectrometry Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; González Domínguez, Raúl; González Domínguez, Raúl; García Barrera, Tamara; García Barrera, Tamara; Gómez Ariza, José Luis; Gómez Ariza, José Luis (Elsevier, 2015-01-05) The identification of pathological mechanisms underlying to Alzheimer's disease is of great importance for the discovery ...
Article Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches González Domínguez, Raúl; González Domínguez, Raúl; García Barrera, Tamara; García Barrera, Tamara; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gómez Ariza, José Luis; Gómez Ariza, José Luis (Elsevier, 2015-01-01) The transgenic mouse APP/PS1 is widely employed by neuroscientists because reproduces well some of the neuropathological ...
Article Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death Carriba, Paulina; Carriba, Paulina; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Navarro, Victoria; Navarro, Victoria; Moreno González, Inés; Moreno González, Inés; Barneda Zahonero, Bruna; Barneda Zahonero, Bruna; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier (Nature Publishing Group, 2015-01-01) The brains of patients with Alzheimer's disease (AD) present elevated levels of tumor necrosis factor-α (TNFα), a cytokine ...
Article Metabolomic investigation of systemic manifestations associated with Alzheimer's disease in the APP/PS1 transgenic mouse model González Domínguez, Raúl; González Domínguez, Raúl; García Barrera, Tamara; García Barrera, Tamara; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gómez Ariza, José Luis; Gómez Ariza, José Luis (Royal Society of Chemistry, 2015-01-01) There is growing evidence that Alzheimer's disease may be a widespread systemic disorder, so peripheral organs could be ...
Article Metabolomic research on the role of interleukin-4 in Alzheimer’s disease González Domínguez, Raúl; González Domínguez, Raúl; García Barrera, Tamara; García Barrera, Tamara; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gómez Ariza, José Luis; Gómez Ariza, José Luis (Springer, 2015-01-01) Inflammation plays a prominent role in the pathogenesis of Alzheimer’s disease, affecting both brain and the peripheral ...
Article Neuroinflammation in Alzheimer's Disease Heneka, Michael T.; Heneka, Michael T.; Carson, Monica J.; Carson, Monica J.; El Khoury, Joseph; El Khoury, Joseph; Landreth, Gary E.; Landreth, Gary E.; Brosseron, Frederik; Brosseron, Frederik; Feinstein, Douglas L.; Feinstein, Douglas L.; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Kummer, Markus P.; Kummer, Markus P. (Elsevier, 2015-01-01) Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment but ...
Article Application of metabolomics based on direct mass spectrometry analysis for the elucidation of altered metabolic pathways in serum from the APP/PS1 transgenic model of Alzheimer's disease González Domínguez, Raúl; González Domínguez, Raúl; García Barrera, Tamara; García Barrera, Tamara; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gómez Ariza, José Luis; Gómez Ariza, José Luis (Elsevier, 2015-01-01) Metabolomic analysis of brain tissue from transgenic mouse models of Alzheimer's disease has demonstrated a great potential ...
Article Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Navarro Garrido, Victoria; Navarro Garrido, Victoria; Moyano González, Francisco Javier; Moyano González, Francisco Javier; Sánchez Mico, María; Sánchez Mico, María; Torres Canalejo, Manuel; Torres Canalejo, Manuel; Dávila Cansino, José Carlos; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier (Public Library of Science, 2014-01-01) The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of ...
Article Region-specific metabolic alterations in the brain of the APP/PS1 transgenic mice of Alzheimer's disease González Domínguez, Raúl; González Domínguez, Raúl; García Barrera, Tamara; García Barrera, Tamara; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gómez Ariza, José Luis; Gómez Ariza, José Luis (Elsevier, 2014-01-01) Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide, but its etiology is still not completely ...
Article In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology Trujillo Estrada, Laura Isabel; Trujillo Estrada, Laura Isabel; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Castro, Vanessa de; Castro, Vanessa de; Torres Canalejo, Manuel; Torres Canalejo, Manuel; Baglietto Vargas, David; Baglietto Vargas, David; Moreno González, Inés; Moreno González, Inés; Navarro Garrido, Victoria; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Dávila Cansino, José Carlos; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier (BioMed Central, 2013-01-01) Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) ...
Presentation Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer Trujillo Estrada, Laura Isabel; Trujillo Estrada, Laura Isabel; Castro, Vanesa de; Castro, Vanesa de; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Dávila Cansino, José Carlos; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia (2013-01-01) El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD).
Article Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Dávila Cansino, José Carlos; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Carmona Cuenca, Irene; Carmona Cuenca, Irene; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Trujillo Estrada, Laura Isabel; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Torres Canalejo, Manuel; Torres Canalejo, Manuel; Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Navarro Garrido, Victoria (2012-01-01) Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies ...
Article Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Trujillo Estrada, Laura Isabel; Trujillo Estrada, Laura Isabel; Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Torres Canalejo, Manuel; Torres Canalejo, Manuel; Baglietto Vargas, David; Baglietto Vargas, David; Moreno González, Inés; Moreno González, Inés; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Ruano Caballero, Diego; Ruano Caballero, Diego; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia (Springer, 2012-01-01) Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). ...
Article Lipopolysacharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus Ríos Sánchez, Rosa María; Ríos Sánchez, Rosa María; Ruano Caballero, Diego; Ruano Caballero, Diego; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Pintado Losa, Cristina; Pintado Losa, Cristina; Gavilán Dorronzoro, Elena; Gavilán Dorronzoro, Elena; García Cuervo, Luisa; García Cuervo, Luisa; Castaño Navarro, Angélica; Castaño Navarro, Angélica; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia; Gavilán Dorronzoro, María de la Paz; Gavilán Dorronzoro, María de la Paz (2012-01-01)
PhD Thesis Factores implicados en la neurodegeneración y el aumento de aβ oligomérico soluble durante el proceso de envejecimiento en un modelo ps1m146lxappsl de la enfermedad de alzheimer Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Torres Canalejo, Manuel; Torres Canalejo, Manuel (2011-05-11) Los Objetivos del Trabajo son: 1. Identificación de la presencia de péptido β-amiloide soluble en el medio extracelular y ...
Article Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density Pintado Losa, Cristina; Pintado Losa, Cristina; Revilla Torres, María Elisa; Revilla Torres, María Elisa; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; García Cuervo, Luisa; García Cuervo, Luisa; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Ruano Caballero, Diego; Ruano Caballero, Diego; Castaño Navarro, Angélica; Castaño Navarro, Angélica (Elsevier, 2011-01-01) To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays ...
Article Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Torres Canalejo, Manuel; Torres Canalejo, Manuel; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Sánchez Mejías, Elisabeth; Trujillo Estrada, Laura Isabel; Trujillo Estrada, Laura Isabel; Carmona Cuenca, Irene; Carmona Cuenca, Irene; Caballero, Cristina M.; Caballero, Cristina M.; Ruano Caballero, Diego; Ruano Caballero, Diego; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier (American Society for Biochemistry and Molecular Biology Inc., 2011-01-01) Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, ...
Article Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition Gavilán Dorronzoro, María de la Paz; Gavilán Dorronzoro, María de la Paz; Pintado Losa, Cristina; Pintado Losa, Cristina; Gavilán Dorronzoro, Elena; Gavilán Dorronzoro, Elena; Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Ríos Sánchez, Rosa María; Ríos Sánchez, Rosa María; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Castaño Navarro, Angélica; Castaño Navarro, Angélica; Ruano Caballero, Diego; Ruano Caballero, Diego (Wiley-Blackwell, 2009-01-01) Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression ...
Article Inflammatory response in the hippocampus of PS1M146L/APP 751SL mouse model of Alzheimer's disease: Age-dependent switch in the microglial phenotype from alternative to classic Jiménez Muñoz, Sebastián; Jiménez Muñoz, Sebastián; Baglietto Vargas, David; Baglietto Vargas, David; Caballero, Cristina M.; Caballero, Cristina M.; Moreno González, Inés; Moreno González, Inés; Torres Canalejo, Manuel; Torres Canalejo, Manuel; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María; Ruano Caballero, Diego; Ruano Caballero, Diego; Vizuete Chacón, María Luisa; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier (Society for Neuroscience, 2008-01-01) Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs ...
PhD Thesis Estudio histopatológico del hipocampo de un modelo animal transgénico PS1XAPP de la enfermedad de Alzheimer Gutiérrez Pérez, Antonia; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Sánchez Varo, Raquel María; Sánchez Varo, Raquel María (2007-03-14)
PhD Thesis Caracterización de los sistemas gabaérgico y colinérgico en hipocampo de ratones transgénicos modelos de la enfermedad de Alzheimer Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Ruano Caballero, Diego; Ruano Caballero, Diego; Ramos Prieto, Blanca; Ramos Prieto, Blanca (2005-07-22)
PhD Thesis Caracterización de los sistemas gabaérgico y colinérgico en neocorteza de ratones transgénicos modelos de la enfermedad de Alzheimer Ruano Caballero, Diego; Ruano Caballero, Diego; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Río Valencia, Juan Carlos del; Río Valencia, Juan Carlos del (2005-07-22)
PhD Thesis Estudio del sistema gabaérgico durante el proceso normal de envejecimiento en el hipocampo de rata Ruano Caballero, Diego; Ruano Caballero, Diego; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Vela Ríos, José; Vela Ríos, José (2004-05-07)
Article GABAa and a-Amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus Ruano Caballero, Diego; Ruano Caballero, Diego; Araujo, Francisco; Araujo, Francisco; Revilla Torres, María Elisa; Revilla Torres, María Elisa; Vela, Jose; Vela, Jose; Bergis, Olivier; Bergis, Olivier; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier (American Society for Biochemistry and Molecular Biology, 2000-01-01) We have investigated the age-dependent modifications in the expression of eight different subunits of the γ-aminobutyric ...
Article Molecular and pharmacological characterization of native cortical γ- aminobutyric acids receptors containing both α1 and α3 subunits Araujo, Francisco; Araujo, Francisco; Tan, Suan; Tan, Suan; Ruano Caballero, Diego; Ruano Caballero, Diego; Schoemaker, Hans J P; Schoemaker, Hans J P; Benavides, Jesús; Benavides, Jesús; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier (1996-01-01) We have investigated the existence, molecular composition, and benzodiazepine binding properties of native cortical α1-α3 ...
PhD Thesis Caracterización farmacológica de la proteína receptora GABAA en el sistema nervioso de la rata: Efecto del envejecimiento Machado de la Quintana, Alberto; Machado de la Quintana, Alberto; Vitorica Ferrández, Francisco Javier; Vitorica Ferrández, Francisco Javier; Ruano Caballero, Diego; Ruano Caballero, Diego (1993-02-12) La caracterización farmacológica de la proteína receptora GABAA, ha puesto de manifiesto la existencia de tres sitios de ...

Author profile: Vitorica Ferrández, Francisco Javier

Institutional data

Statistics

56

7603

13753

Publications