Data

NameVitorica Ferrández, Francisco Javier
DepartmentBioquímica y Biología Molecular
Knowledge areaBioquímica y Biología Molecular
Professional categoryCatedrático de Universidad
E-mailRequest
         

  Statistics

  • Items

    32

  • Visits

    3745

  • Downloads

    4427

  Publications

 

PhD Thesis
Icon

Implicación de la disfunción glial en la evolución de la patología en pacientes de Alzheimer

Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa; Muñoz Castro, Clara (2021-01-20)
La enfermedad de Alzheimer (EA) es un proceso neurodegenerativo que cursa con un deterioro progresivo de las funciones ...
Article
Icon

Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases

Pérez Jiménez, Mercedes María; Monje Moreno, José Manuel; Brokate Llanos, Ana María; Venegas Calerón, Mónica; Sánchez García, Alicia; Sansigre, Paula; Valladares, Amador; Esteban García, Sara; Suárez Pereira, Irene; Vitorica Ferrández, Francisco Javier; Ríos, José Julián; Artal Sanz, Marta; Carrión, Ángel Manuel; Muñoz, Manuel Jesús (Springer Nature, 2021-01-01)
Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases ...
Article
Icon

Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice

Larramona Arcas, Raquel; González Arias, Candela; Perea, Gertrudis; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; García Barrera, Tamara; Gómez Ariza, José Luis; Pascua Maestro, Raquel; Ganfornina, María Dolores; Kara, Eleanna; Martínez Vicente, Marta (BMC, 2020-01-01)
Background The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes ...
Article
Icon

Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease

García León, Juan Antonio; Cáceres Palomo, Laura; Sánchez Mejías, Elisabeth; Mejías Ortega, Marina; Núñez Díaz, Cristina; Fernández Valenzuela, Juan José; Sánchez Varo, Raquel; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (MDPI, 2020-01-01)
Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s ...
Article
Icon

Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model

Fernández Valenzuela, Juan José; Muñoz Castro, Clara; Jiménez Muñoz, Sebastián; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutierrez Pérez, Antonia (Nature Research, 2020-01-01)
In Alzheimer’s disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity ...
Article
Icon

Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells

García Bonilla, María; García-Martín, María Luisa; Ojeda Pérez, Betsaida; Muñoz Hernández, Mª Carmen; Vitorica Ferrández, Francisco Javier; Jiménez Muñoz, Sebastián; Cifuentes, Manuel; Santos Ruíz, Leonor; Shumilov, Kirill; Claros, Silvia; Páez González, Patricia; Jiménez, Antonio J. (BMC, 2020-01-01)
BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial ...
PhD Thesis
Icon

Caracterización de la respuesta y función astroglial en modelos y pacientes de la enfermedad de Alzheimer.

Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa; Sánchez Mico, María (2019-03-25)
Article
Icon

Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology

Romero Molina, Carmen; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Jiménez Muñoz, Sebastián; Fernández Valenzuela, Juan José; Sánchez Mico, María; Muñoz Castro, Clara; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Frontiers Media Research Foundation, 2018-11-14)
Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease ...
Article
Icon

Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative

Navarro Garrido, Victoria; Sánchez Mejías, Elisabeth; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Varo, Raquel María; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Frontiers Media, 2018-01-01)
Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative ...
Article
Icon

Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo

Serrano Pozo, Alberto; Sánchez García, Manuel A.; Heras Garvín, Antonio; March Díaz, Rosana Rocío; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; López Barneo, José; Vitorica Ferrández, Francisco Javier; Pascual, Alberto (Public Library of Science, 2017-01-01)
Background Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number ...
Final Degree Project
Icon

Estrategias terapéuticas en la efermedad de alzheimer

Vitorica Ferrández, Francisco Javier; Riera LLull, Nieves (2017-01-01)
Article
Icon

Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease

Baglietto-Vargas, David; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura; Gómez Arboledas, Ángela; Sánchez Mico, María; Sánchez Varo, Raquel; Vizuete Chacón, María Luisa; Dávila, José Carlos; García Verdugo, José Manuel; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (Nature Research (part of Springer Nature), 2017-01-01)
Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. ...
PhD Thesis
IconIcon

Efectos de la acumulación del péptido Beta amiloide en tejido cerebral de ratones PS1xAPP modelos de la Enfermedad de Alzheimer

Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa; Jiménez Muñoz, Sebastián (2016-01-15)
Esta enfermedad se ha convertido en el tercer problema de salud más grave en los países desarrollados (detrás de los ...
Article
Icon

Soluble phospho‑tau from Alzheimer’s disease hippocampus drives microglial degeneration

Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez, Sebastián; Sánchez Mico, María; Sánchez Varo, Raquel; Núñez Díaz, Cristina; Trujillo Estrada, Laura; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer (part of Springer Nature): Springer Open Choice Hybrid Journals, 2016-01-01)
The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, ...
Article
Icon

Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-βInduced Neuronal Death

Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Fernández, Ana M.; Hervasa, Rubén; Gómez Gutiérrez, Patricia; Vega, Miguel (IOS Press, 2016-01-01)
Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain ...
Article
Icon

Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death

Carriba, Paulina; Jiménez, Sebastián; Navarro, Victoria; Moreno González, Inés; Barneda Zahonero, Bruna; Vitorica Ferrández, Francisco Javier (Nature Publishing Group, 2015-01-01)
The brains of patients with Alzheimer's disease (AD) present elevated levels of tumor necrosis factor-α (TNFα), a cytokine ...
Article
Icon

Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains

Jiménez, Sebastián; Navarro Garrido, Victoria; Moyano, Javier; Sánchez Mico, María; Torres, Manuel; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Public Library of Science, 2014-01-01)
The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of ...
Article
Icon

In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology

Trujillo Estrada, Laura Isabel; Jiménez, Sebastián; Castro, Vanessa de; Torres, Manuel; Baglietto-Vargas, David; Moreno González, Inés; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (BioMed Central, 2013-01-01)
Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) ...
Presentation
Icon

Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer

Trujillo Estrada, Laura Isabel; De Castro, Vanesa; Jiménez Muñoz, Sebastián; Sánchez Varo, Raquel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Davila, JC; Vitorica Ferrández, Francisco Javier; Gutiérrez, A. (2013-01-01)
El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD).
Article
Icon

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Carmona Cuenca, Irene; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Sánchez Varo, Raquel María; Torres Canalejo, Manuel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria (2012-01-01)
Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies ...
Article
Icon

Lipopolysacharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus

Ríos, Rosa M.; Ruano Caballero, Diego; Vitorica Ferrández, Francisco Javier; Pintado Losa, Cristina; Gavilán Dorronzoro, Elena; García Cuervo, Luisa; Castaño Navarro, Angélica; Gutiérrez Pérez, Antonia; Gavilán, María P. (2012-01-01)
PhD Thesis
Icon

Factores implicados en la neurodegeneración y el aumento de aβ oligomérico soluble durante el proceso de envejecimiento en un modelo ps1m146lxappsl de la enfermedad de alzheimer

Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa; Torres Canalejo, Manuel (2011-05-11)
Los Objetivos del Trabajo son: 1. Identificación de la presencia de péptido β-amiloide soluble en el medio extracelular y ...
Article
Icon

Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density

Pintado Losa, Cristina; Revilla Torres, María Elisa; Vizuete Chacón, María Luisa; García Cuervo, Luisa; Vitorica Ferrández, Francisco Javier; Ruano Caballero, Diego; Castaño Navarro, Angélica (Elsevier, 2011-01-01)
To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays ...
Article
Icon

Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model

Jiménez, Sebastián; Torres, Manuel; Vizuete Chacón, María Luisa; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Trujillo Estrada, Laura Isabel; Carmona Cuenca, Irene; Caballero, Cristina M.; Ruano Caballero, Diego; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (American Society for Biochemistry and Molecular Biology Inc., 2011-01-01)
Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, ...
Article
Icon

Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition

Gavilán, María Paz; Pintado Losa, Cristina; Gavilán Dorronzoro, Elena; Jiménez, Sebastián; Ríos, Rosa M.; Vitorica Ferrández, Francisco Javier; Castaño Navarro, Angélica; Ruano Caballero, Diego (Wiley-Blackwell, 2009-01-01)
Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression ...
Article
Icon

Inflammatory response in the hippocampus of PS1M146L/APP 751SL mouse model of Alzheimer's disease: Age-dependent switch in the microglial phenotype from alternative to classic

Jiménez, Sebastián; Baglietto-Vargas, David; Caballero, Cristina M.; Moreno González, Inés; Torres, Manuel; Sánchez Varo, Raquel María; Ruano Caballero, Diego; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Society for Neuroscience, 2008-01-01)
Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs ...
PhD Thesis
Icon

Estudio histopatológico del hipocampo de un modelo animal transgénico PS1XAPP de la enfermedad de Alzheimer

Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Sánchez Varo, Raquel María (2007-03-14)
PhD Thesis
Icon

Caracterización de los sistemas gabaérgico y colinérgico en hipocampo de ratones transgénicos modelos de la enfermedad de Alzheimer

Vitorica Ferrández, Francisco Javier; Ruano Caballero, Diego; Ramos Prieto, Blanca (2005-07-22)
PhD Thesis
Icon

Estudio del sistema gabaérgico durante el proceso normal de envejecimiento en el hipocampo de rata

Ruano Caballero, Diego; Vitorica Ferrández, Francisco Javier; Vela Ríos, José (2004-05-07)
Article
Icon

GABAa and a-Amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus

Ruano Caballero, Diego; Araujo, Francisco; Revilla Torres, María Elisa; Vela, Jose; Bergis, Olivier; Vitorica Ferrández, Francisco Javier (American Society for Biochemistry and Molecular Biology, 2000-01-01)
We have investigated the age-dependent modifications in the expression of eight different subunits of the γ-aminobutyric ...
Article
Icon

Molecular and pharmacological characterization of native cortical γ- aminobutyric acids receptors containing both α1 and α3 subunits

Araujo, Francisco; Tan, Suan; Ruano Caballero, Diego; Schoemaker, Hans J P; Benavides, Jesús; Vitorica Ferrández, Francisco Javier (1996-01-01)
We have investigated the existence, molecular composition, and benzodiazepine binding properties of native cortical α1-α3 ...
PhD Thesis
Icon

Caracterización farmacológica de la proteína receptora GABAA en el sistema nervioso de la rata: Efecto del envejecimiento

Machado de la Quintana, Alberto; Vitorica Ferrández, Francisco Javier; Ruano Caballero, Diego (1993-02-12)
La caracterización farmacológica de la proteína receptora GABAA, ha puesto de manifiesto la existencia de tres sitios de ...