Artículo
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Autor/es | Sánchez Varo, Raquel María
Mejías Ortega, Marina Fernández Valenzuela, Juan José Núñez Díaz, Cristina Cáceres Palomo, Laura Vegas Gómez, Laura Sánchez Mejías, Elisabeth Trujillo Estrada, Laura Isabel García León, Juan Antonio Moreno González, Inés Vizuete Chacón, María Luisa Vitorica Ferrández, Francisco Javier Baglietto Vargas, David Gutiérrez Pérez, Antonia |
Departamento | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-05-27 |
Publicado en |
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Resumen | Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations ... Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations in amyloid precursor protein (APP) and presenilins (PS) genes. However, due to the repeated failure of translational applications from animal models to human patients, along with the recent advances in genetic susceptibility and our current understanding on disease biology, these models have evolved over time in an attempt to better reproduce the complexity of this devastating disease and improve their applicability. In this review, we provide a comprehensive overview about the major pathological elements of human AD (plaques, tauopathy, synaptic damage, neuronal death, neuroinflammation and glial dysfunction), discussing the knowledge that available mouse models have provided about the mechanisms underlying human disease. Moreover, we highlight the pros and cons of current models, and the revolution offered by the concomitant use of transgenic mice and omics technologies that may lead to a more rapid improvement of the present modeling battery. |
Agencias financiadoras | Instituto de Salud Carlos III Junta de Andalucía Ministerio de Ciencia e Innovación (MICIN). España Alzheimer Association Universidad de Málaga |
Identificador del proyecto | PI21/00915
PI21/00914 UMA18-FEDERJA-211 UMA20-FEDERJA-104 P18-RT-2233 US-1262734 PI-0276-2018 AARG-22-928219 PID2019-108911RA-100 PID2019-107090RA-100 B1-2019_07 B1-2020_04 B1-2019_06 |
Cita | Sánchez Varo, R.M., Mejías Ortega, M., Fernández Valenzuela, J.J., Núñez Díaz, C., Cáceres Palomo, L., Vegas Gómez, L.,...,Gutiérrez Pérez, A. (2022). Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis. International Journal of Molecular Sciences, 23 (10), 5404. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Transgenic Mouse Models.pdf | 4.074Mb | [PDF] | Ver/ | |