Artículo
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease
Autor/es | Baglietto Vargas, David
Sánchez Mejías, Elisabeth Navarro Garrido, Victoria Jiménez Muñoz, Sebastián Trujillo Estrada, Laura Isabel Gómez Arboledas, Ángela Sánchez Mico, María Sánchez Varo, Raquel María Vizuete Chacón, María Luisa Dávila Cansino, José Carlos García Verdugo, José Manuel Vitorica Ferrández, Francisco Javier Gutiérrez Pérez, Antonia |
Departamento | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular |
Fecha de publicación | 2017 |
Fecha de depósito | 2020-04-22 |
Publicado en |
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Resumen | Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors ... Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors underlying memory defects in Alzheimer’s patients. In this regard, new evidence linking Alzheimer’s disease-related pathology and neuronal stem cells suggests that hippocampal neurogenesis impairment is an important factor underlying these cognitive deficits. However, because of conflicting results, the impact of Aβ pathology on neurogenesis/gliogenesis remains unclear. Here, we investigated the effect of Aβ on neuronal and glial proliferation by using an APP/PS1 transgenic model and in vitro assays. Specifically, we showed that neurogenesis is affected early in the APP/PS1 hippocampus, as evidenced by a significant decrease in the proliferative activity due to a reduced number of both radial glia-like neural stem cells (type-1 cells) and intermediate progenitor cells (type-2 cells). Moreover, we demonstrated that soluble Aβ from APP/PS1 mice impairs neuronal cell proliferation using neurosphere cultures. On the other hand, we showed that oligomeric Aβ stimulates microglial proliferation, whereas no effect was observed on astrocytes. These findings indicate that Aβ has a differential effect on hippocampal proliferative cells by inhibiting neuronal proliferation and triggering the formation of microglial cells. |
Agencias financiadoras | Instituto de Salud Carlos III Junta de Andalucía European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Identificador del proyecto | PI12/01431
PI15/00796 PI12/01439 PI15/00957 CTS-2035 |
Cita | Baglietto Vargas, D., Sánchez Mejías, E., Navarro Garrido, V., Jiménez Muñoz, S., Trujillo Estrada, L.I., Gómez Arboledas, Á.,...,Gutiérrez Pérez, A. (2017). Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease. Scientific Reports, 7, 10085. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Dual roles .pdf | 14.50Mb | [PDF] | Ver/ | |