Artículo
Effect of metabolites of hydroxytyrosol on protection against oxidative stress and inflammation in human endothelial cells
Autor/es | López Martín, Sergio
Montserrat de la Paz, Sergio Lucas Rodríguez, Ricardo Bermúdez Pulgarín, Beatriz Abia González, María del Rocío Morales, Juan C. García Muriana, Francisco José |
Departamento | Universidad de Sevilla. Departamento de Biología Celular Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica |
Fecha de publicación | 2017 |
Fecha de depósito | 2022-03-14 |
Publicado en |
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Resumen | The effects of chemically synthesized metabolites (sulfate and glucuronate forms) from hydroxytyrosol (HTyr) on oxidative stress and inflammation were investigated in TNF-α-activated human endothelial cells. HTyr sulfate ... The effects of chemically synthesized metabolites (sulfate and glucuronate forms) from hydroxytyrosol (HTyr) on oxidative stress and inflammation were investigated in TNF-α-activated human endothelial cells. HTyr sulfate metabolites decreased reactive oxygen species and prevented the decrease in glutathione, glutathione peroxidase 1, and glutamate-cysteine ligase catalytic subunit and up-regulated heme oxygenase-1 levels. HTyr and all tested HTyr metabolites (HTyr sulfate > HTyr glucuronate > HTyr) suppressed the phosphorylation of nuclear factor kappa B proteins, the gene expression of intercellular and vascular adhesion molecules, E-selectin, chemokine (CC) motif ligand 2, and prostaglandin-endoperoxidase synthase 2 and the adhesion of human monocytes. In addition, HTyr sulfate metabolites suppressed plantar and ear swelling and myeloperoxidase activity in inflamed ear tissue in mice treated with carrageenan or 12-O-tetradecanoylphorbol-13-acetate. This study demonstrates the antioxidant and/or anti-inflammatory properties of HTyr metabolites in TNF-α-activated hECs and in the prevention of acute and chronic inflammation in mice. |
Agencias financiadoras | Consejo Superior de Investigaciones Científicas (CSIC) |
Identificador del proyecto | 09-CVI-5007
ES-2012-056104 JCI-2012-13084 JAEDOC089 |
Cita | López Martín, S., Montserrat de la Paz, S., Lucas Rodríguez, R., Bermúdez Pulgarín, B., Abia González, M.d.R., Morales, J.C. y García Muriana, F.J. (2017). Effect of metabolites of hydroxytyrosol on protection against oxidative stress and inflammation in human endothelial cells. Journal of Functional Foods, 29, 238-247. |
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