NombreLucas Rodríguez, Ricardo
DepartamentoQuímica Orgánica y Farmaceútica
Área de conocimientoQuímica Orgánica
Categoría profesionalProfesor Titular de Universidad
Correo electrónicoSolicitar
         
  • Nº publicaciones

    28

  • Nº visitas

    3622

  • Nº descargas

    3580


 

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Synthesis and Antimicrobial Activity of Aminoalkyl Resveratrol Derivatives Inspired by Cationic Peptides

Cebrián, Rubén; Lucas Rodríguez, Ricardo; Fernández Cantos, María Victoria; Slot, Koen; Peñalver, Pablo; Martínez García, Marta; Párraga Leo, Antonio; Paz Báñez, María Violante de; García, Federico; Kuipers, Oscar P.; Morales, Juan Carlos (Taylor & Francis, 2023)
Antimicrobial resistance is a global concern, far from being resolved. The need of new drugs against new targets is imminent. ...
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Neuroprotective and Anti-inflammatory Effects of Pterostilbene Metabolites in Human Neuroblastoma SH-SY5Y and RAW 264.7 Macrophage Cells

Peñalver, Pablo; Zodio, Sonia; Lucas Rodríguez, Ricardo; Paz Báñez, María Violante de; Morales, Juan Carlos (American Chemical Society, 2020)
Oxidative stress is known to be a key factor in many neurodegenerative diseases. Inflammation also plays a relevant role ...
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In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

Iglesias Blanco, Nieves; Galbis Fuster, Elsa; Romero Azogil, Lucía; Benito Hernández, Elena María; García Martín, María de Gracia; Lucas Rodríguez, Ricardo; Paz Báñez, María Violante de (MDPI, 2020)
The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. ...
Trabajo Fin de Grado
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El fútbol como medio para la inclusión social en Educación Primaria

Ramírez Ramos, Lucía; Lucas Rodríguez, Ricardo (2020)
Para este trabajo de Fin de Grado se ha realizado un estudio sobre el deporte, más concretamente, sobre la inclusión ...
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Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release

Iglesias, N.; Galbis Fuster, Elsa; Díaz Blanco, Manuel Jesús; Lucas Rodríguez, Ricardo; Benito Hernández, Elena María; Paz Báñez, María Violante de (MDPI, 2019)
In the present work, we demonstrate the preparation of chitosan-based composites as vehicles of the natural occurring ...
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Validation of Smart Nanoparticles as Controlled Drug Delivery Systems: Loading and pH-Dependent Release of Pilocarpine

Galbis Fuster, Elsa; Iglesias, N.; Lucas Rodríguez, Ricardo; Tinajero Díaz, Ernesto; Paz Báñez, María Violante de; Muñoz Guerra, Sebastián; Galbis Pérez, Juan Antonio (American Chemical Society, 2018)
Micelles are good devices for use as controlled drug delivery systems because they exhibit the ability to protect the ...
Trabajo Fin de Grado
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¿Está presente la diversidad familiar en el aula?

Donoso Ruiz-Castizo, Leonardo; Lucas Rodríguez, Ricardo (2018)
El siguiente trabajo de fin de grado pretende la visión, tanto de docentes como del alumnado, del tercer ciclo de Educación ...
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Glucose-nucleobase pairs within DNA: Impact of hydrophobicity, alternative linking unit and DNA polymerase nucleotide insertion studies

Vengut Climent, Empar; Peñalver, Pablo; Lucas Rodríguez, Ricardo; Gómez Pinto, Irene; Aviñó, Anna; Muro Pastor, Alicia María; Galbis Fuster, Elsa; Paz Báñez, María Violante de; Fonseca Guerra, Célia; Bickelhaupt, F. Matthias; Eritja, Ramón; González, Carlos; Morales, Juan Carlos (Royal Society of Chemistry, 2018)
Recently, we studied glucose-nucleobase pairs, a binding motif found in aminoglycoside-RNA recognition. DNA duplexes with ...
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pH-Responsive Polymeric Nanoparticles as Drug Delivery Systems

Galbis Fuster, Elsa; Paz Báñez, María Violante de; Iglesias, N.; Lucas Rodríguez, Ricardo; Galbis Pérez, Juan Antonio (JSciMed Central, 2017)
Micelles are excellent devices to be used as controlled drug delivery systems since they exhibit the ability to protect ...
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Effect of metabolites of hydroxytyrosol on protection against oxidative stress and inflammation in human endothelial cells

López Martín, Sergio; Montserrat de la Paz, Sergio; Lucas Rodríguez, Ricardo; Bermúdez Pulgarín, Beatriz; Abia González, María del Rocío; Morales, Juan C.; García Muriana, Francisco José (Elsevier, 2017)
The effects of chemically synthesized metabolites (sulfate and glucuronate forms) from hydroxytyrosol (HTyr) on oxidative ...
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Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells

García Muriana, Francisco José; Montserrat de la Paz, Sergio; Lucas Rodríguez, Ricardo; Bermúdez Pulgarín, Beatriz; Jaramillo Carmona, Sara; Morales, Juan C.; Abia González, María del Rocío; López Martín, Sergio (Royal Society of Chemistry, 2017)
Tyrosol (Tyr) is a phenolic compound found in virgin olive oil. After ingestion, Tyr undergoes extensive first pass ...
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Tyrosol and hydroxytyrosol derivatives as antitrypanosomal and antileishmanial agents

Belmonte Reche, Efres; Martínez García, Marta; Peñalver, Pablo; Gómez Pérez, Verónica; Lucas Rodríguez, Ricardo; Gamarro, Francisco; Pérez Victoria, José María; Morales, Juan Carlos (Elsevier, 2016)
Trypanosomiasis and leishmaniasis keep being a real challenge for health and development of African countries. Existing ...
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Cytotoxic, Antiangiogenic and Antitelomerase Activity of Glucosyl- and Acyl- Resveratrol Prodrugs and Resveratrol Sulfate Metabolites

Falomir, Eva; Lucas Rodríguez, Ricardo; Peñalver, Pablo; Martí Centelles, Rosa; Dupont, Alexia; Zafra-Gómez, Alberto; Carda, Miguel; Morales, Juan C. (Wiley-Blackwell, 2016)
Resveratrol (RES) is a natural polyphenol with relevant and varied biological activity. However, its low bioavailability ...
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Hydroxytyrosol and tyrosol sulfate metabolites protect against the oxidized cholesterol pro-oxidant effect in Caco-2 human enterocyte-like cells

Atzeri, Angela; Lucas Rodríguez, Ricardo; Incani, Alessandra; Peñalver, Pablo; Zafra-Gómez, Alberto; Melis, M. Paola; Pizzala, Roberto; Morales, Juan C.; Deiana, Monica (Royal Society of Chemistry, 2016)
The aim of this study was to investigate the ability of the sulfate metabolites of hydroxytyrosol (HT) and tyrosol (TYR) ...
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Glucose–Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA

Vengut Climent, Empar; Gómez Pinto, Irene; Lucas Rodríguez, Ricardo; Peñalver, Pablo; Aviñó, Anna; Fonseca Guerra, Célia; Bickelhaupt, F. Matthias; Eritja, Ramón; González, Carlos; Morales, Juan C. (Wiley-Blackwell, 2016)
Noncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside–RNA ...
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Antioxidant activity of alkyl gallates and glycosyl alkyl gallates in fish oil in water emulsions: Relevance of their surface active properties and of the type of emulsifier

González, M. Jesús; Medina, Isabel; Maldonado, Olivia S.; Lucas Rodríguez, Ricardo; Morales, Juan C. (Elsevier, 2015)
The antioxidant activity of gallic acid and a series of alkyl gallates (C4-C18) and glycosylated alkyl gallates (C4-C18) ...
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Effects of Sugar Functional Groups, Hydrophobicity, and Fluorination on Carbohydrate–DNA Stacking Interactions in Water

Lucas Rodríguez, Ricardo; Peñalver, Pablo; Gomez Pinto, Irene; Vengut Climent, Empar; Matashobya, L.; Cousin, J.; Sanchez Maldonado, Olivia; Reynes, Virginie; Aviñó, Anna; Eritja Casadellà, Ramón; González, Carlos; Linclau, Bruno; Morales, Juan C. (American Chemical Society, 2014)
Carbohydrate–aromatic interactions are highly relevant for many biological processes. Nevertheless, experimental data in ...
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Carbohydrate-DNA interactions at G-quadruplexes: Folding and stability changes by attaching sugars at the 5′-End

Gómez Pinto, Irene; Vengut Climent, Empar; Lucas Rodríguez, Ricardo; Aviñó, Anna; Eritja, Ramón; González, Carlos; Morales, Juan Carlos (Wiley-Blackwell, 2013)
Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, ...
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The Gut Microbiota Ellagic Acid-Derived Metabolite Urolithin A and Its Sulfate Conjugate Are Substrates for the Drug Efflux Transporter Breast Cancer Resistance Protein (ABCG2/BCRP)

González Sarrías, Antonio; Miguel, Verónica; Merino, Gracia; Lucas Rodríguez, Ricardo; Morales, Juan C.; Tomás Barberán, Francisco; Álvarez, Ana I.; Espín, Juan C. (American Chemical Society, 2013)
The breast cancer resistance protein (BCRP/ABCG2) is a drug efflux transporter that can affect the pharmacological and ...
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Synthesis, RNAi activity and nuclease-resistant properties of apolar carbohydrates siRNA conjugates

Vengut Climent, Empar; Terrazas, Montserrat; Lucas Rodríguez, Ricardo; Arévalo Ruiz, Matilde; Eritja, Ramón; Morales, Juan Carlos (Elsevier, 2013)
Oligoribonucleotide conjugates carrying apolar carbohydrates at the 5′-end and the corresponding siRNA duplexes have been ...
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Apolar carbohydrates as DNA capping agents

Lucas Rodríguez, Ricardo; Vengut Climent, Empar; Gómez Pinto, Irene; Aviñó, Anna; Eritja, Ramón; González, Carlos; Morales, Juan Carlos (Royal Society of Chemistry, 2012)
Mono- and disaccharides have been shown to stack on top of DNA duplexes stabilizing sequences with terminal C–G base pairs. ...
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Resveratrol and some glucosyl, glucosylacyl, and glucuronide derivatives reduce Escherichia coli O157:H7, Salmonella typhimurium, and Listeria monocytogenes Scott A adhesion to colonic epithelial cell lines

Selma, María V.; Larrosa, Mar; Beltrán, David; Lucas Rodríguez, Ricardo; Morales, Juan C.; Tomás-Barberán, Francisco; Espín, Juan C. (American Chemical Society, 2012)
The efficacy of resveratrol and some glucosyl, glucosylacyl, and glucuronide derivatives in inhibiting the adhesion of ...
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Metabolites and tissue distribution of resveratrol in the pig

Azorín-Ortuño, María; Yáñez-Gascón, María J.; Vallejo, Fernando; Pallarés, Francisco J.; Larrosa, Mar; Lucas Rodríguez, Ricardo; Morales, Juan C.; Tomás-Barberán, Francisco A.; García-Conesa, María T.; Espín, Juan C. (Wiley-Blackwell, 2011)
Scope: trans-Resveratrol (RES) and/(or) its metabolites exert many effects in vivo. Our aim was to study the metabolism ...
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Highly Polar Carbohydrates Stack Onto DNA Duplexes Via CH/π Interactions

Lucas Rodríguez, Ricardo; Gómez Pinto, Irene; Aviñó, Anna; Reina, Jose J.; Eritja, Ramón; González, Carlos; Morales, Juan C. (American Chemical Society, 2011)
Carbohydrate-nucleic acid contacts are known to be a fundamental part of some drug-DNA recognition processes. Most of these ...
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Synthesis and in vitro inhibition properties of siRNA conjugates carrying glucose and galactose with different presentations

Aviñó, Anna; Ocampo, Sandra M.; Lucas Rodríguez, Ricardo; Reina, José Juan; Morales, Juan Carlos; Perales, José Carlos; Eritja, Ramón (Springer Nature, 2011)
Oligoribonucleotide conjugates and the corresponding siRNA duplexes against tumor necrosis factor carrying one, two, or ...
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Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents

Larrosa, Mar; Tomé-Carneiro, Joao; Yáñez-Gascón, María J.; Alcántara, David; Selma, María V.; Beltrán, David; García-Conesa, María T.; Urbán, Cristina; Lucas Rodríguez, Ricardo; Tomás-Barberán, Francisco; Morales, Juan C.; Espín, Juan Carlos (American Chemical Society, 2010)
There is no pharmaceutical or definitive surgical cure for inflammatory bowel diseases (IBDs). The naturally occurring ...
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Synthesis, cell-surface binding, and cellular uptake of fluorescently labeled glucose-DNA conjugates with different carbohydrate presentation

Ugarte Uribe, Begoña; Pérez Rentero, Sonia; Lucas Rodríguez, Ricardo; Aviñó, Anna; Reina, José Juan; Alkorta, Itziar; Eritja, Ramón; Morales, Juan Carlos (American Chemical Society, 2010)
Oligonucleotide conjugates carrying carbohydrates at the 5′-end have been prepared. Glucose, fucose, and saccharides ...
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Surface-Active Properties of Lipophilic AntioxidantsTyrosol and Hydroxytyrosol Fatty Acid Esters: A PotentialExplanation for the Nonlinear Hypothesis of the AntioxidantActivity in Oil-in-Water Emulsions

Lucas Rodríguez, Ricardo; Comelles, Francisco; Alcántara, David; Maldonado, Olivia S.; Curcuroze, Melanie; Parra, Jose L.; Morales, Juan C. (American Chemical Society, 2001)
Our group has recently observed a nonlinear tendency in antioxidant capacity of different hydroxytyrosol fatty acid esters ...