Artículo
Glucose–Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA
Autor/es | Vengut Climent, Empar
Gómez Pinto, Irene Lucas Rodríguez, Ricardo Peñalver, Pablo Aviñó, Anna Fonseca Guerra, Célia Bickelhaupt, F. Matthias Eritja, Ramón González, Carlos Morales, Juan C. |
Departamento | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica |
Fecha de publicación | 2016 |
Fecha de depósito | 2022-07-08 |
Publicado en |
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Resumen | Noncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside–RNA recognition, glucose-nucleobase pairs have been examined. Deoxyoligonucleotides with a ... Noncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside–RNA recognition, glucose-nucleobase pairs have been examined. Deoxyoligonucleotides with a 6-deoxyglucose insertion are able to hybridize with their complementary strand, thus exhibiting a preference for purine nucleobases. Although the resulting double helices are less stable than natural ones, they present only minor local distortions. 6-Deoxyglucose stays fully integrated in the double helix and its OH groups form two hydrogen bonds with the opposing guanine. This 6-deoxyglucose-guanine pair closely resembles a purine-pyrimidine geometry. Quantum chemical calculations indicate that glucose-purine pairs are as stable as a natural T-A pair. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España |
Identificador del proyecto | CTQ2011-15203-E
CTQ2012-35360 CTQ2014-52588-R BFU2014-52864-R |
Cita | Vengut Climent, E., Gómez Pinto, I., Lucas Rodríguez, R., Peñalver, P., Aviñó, A., Fonseca Guerra, C.,...,Morales, J.C. (2016). Glucose–Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA. Angewandte Chemie - International Edition, 55 (30), 8643-8647. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Glucose–NucleobasePseudo.pdf | 2.435Mb | [PDF] | Ver/ | |