dc.creator | Vengut Climent, Empar | es |
dc.creator | Gómez Pinto, Irene | es |
dc.creator | Lucas Rodríguez, Ricardo | es |
dc.creator | Peñalver, Pablo | es |
dc.creator | Aviñó, Anna | es |
dc.creator | Fonseca Guerra, Célia | es |
dc.creator | Bickelhaupt, F. Matthias | es |
dc.creator | Eritja, Ramón | es |
dc.creator | González, Carlos | es |
dc.creator | Morales, Juan C. | es |
dc.date.accessioned | 2022-07-08T15:11:53Z | |
dc.date.available | 2022-07-08T15:11:53Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Vengut Climent, E., Gómez Pinto, I., Lucas Rodríguez, R., Peñalver, P., Aviñó, A., Fonseca Guerra, C.,...,Morales, J.C. (2016). Glucose–Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA. Angewandte Chemie - International Edition, 55 (30), 8643-8647. | |
dc.identifier.issn | 1433-7851 | es |
dc.identifier.issn | 1521-3773 | es |
dc.identifier.uri | https://hdl.handle.net/11441/135179 | |
dc.description.abstract | Noncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside–RNA recognition, glucose-nucleobase pairs have been examined. Deoxyoligonucleotides with a 6-deoxyglucose insertion are able to hybridize with their complementary strand, thus exhibiting a preference for purine nucleobases. Although the resulting double helices are less stable than natural ones, they present only minor local distortions. 6-Deoxyglucose stays fully integrated in the double helix and its OH groups form two hydrogen bonds with the opposing guanine. This 6-deoxyglucose-guanine pair closely resembles a purine-pyrimidine geometry. Quantum chemical calculations indicate that glucose-purine pairs are as stable as a natural T-A pair. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad CTQ2011-15203-E, CTQ2012-35360, CTQ2014-52588-R, BFU2014-52864-R | es |
dc.format | application/pdf | es |
dc.format.extent | 5 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley-Blackwell | es |
dc.relation.ispartof | Angewandte Chemie - International Edition, 55 (30), 8643-8647. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | DNA | es |
dc.subject | Hydrogen bonds | es |
dc.subject | NMR spectroscopy | es |
dc.subject | Noncovalent interactions | es |
dc.subject | Nucleobases | es |
dc.title | Glucose–Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.relation.projectID | CTQ2011-15203-E | es |
dc.relation.projectID | CTQ2012-35360 | es |
dc.relation.projectID | CTQ2014-52588-R | es |
dc.relation.projectID | BFU2014-52864-R | es |
dc.relation.publisherversion | https://doi.org/10.1002/anie.201603510 | es |
dc.identifier.doi | 10.1002/anie.201603510 | es |
dc.journaltitle | Angewandte Chemie - International Edition | es |
dc.publication.volumen | 55 | es |
dc.publication.issue | 30 | es |
dc.publication.initialPage | 8643 | es |
dc.publication.endPage | 8647 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |