dc.creator | López Martín, Sergio | es |
dc.creator | Montserrat de la Paz, Sergio | es |
dc.creator | Lucas Rodríguez, Ricardo | es |
dc.creator | Bermúdez Pulgarín, Beatriz | es |
dc.creator | Abia González, María del Rocío | es |
dc.creator | Morales, Juan C. | es |
dc.creator | García Muriana, Francisco José | es |
dc.date.accessioned | 2022-03-14T15:49:18Z | |
dc.date.available | 2022-03-14T15:49:18Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | López Martín, S., Montserrat de la Paz, S., Lucas Rodríguez, R., Bermúdez Pulgarín, B., Abia González, M.d.R., Morales, J.C. y García Muriana, F.J. (2017). Effect of metabolites of hydroxytyrosol on protection against oxidative stress and inflammation in human endothelial cells. Journal of Functional Foods, 29, 238-247. | |
dc.identifier.issn | 1756-4646 | es |
dc.identifier.uri | https://hdl.handle.net/11441/130762 | |
dc.description.abstract | The effects of chemically synthesized metabolites (sulfate and glucuronate forms) from hydroxytyrosol (HTyr) on oxidative stress and inflammation were investigated in TNF-α-activated human endothelial cells. HTyr sulfate metabolites decreased reactive oxygen species and prevented the decrease in glutathione, glutathione peroxidase 1, and glutamate-cysteine ligase catalytic subunit and up-regulated heme oxygenase-1 levels. HTyr and all tested HTyr metabolites (HTyr sulfate > HTyr glucuronate > HTyr) suppressed the phosphorylation of nuclear factor kappa B proteins, the gene expression of intercellular and vascular adhesion molecules, E-selectin, chemokine (CC) motif ligand 2, and prostaglandin-endoperoxidase synthase 2 and the adhesion of human monocytes. In addition, HTyr sulfate metabolites suppressed plantar and ear swelling and myeloperoxidase activity in inflamed ear tissue in mice treated with carrageenan or 12-O-tetradecanoylphorbol-13-acetate. This study demonstrates the antioxidant and/or anti-inflammatory properties of HTyr metabolites in TNF-α-activated hECs and in the prevention of acute and chronic inflammation in mice. | es |
dc.description.sponsorship | Junta de Andalucía 09-CVI-5007 | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación ES-2012-056104 | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad JCI-2012-13084 | es |
dc.format | application/pdf | es |
dc.format.extent | 50 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Journal of Functional Foods, 29, 238-247. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Endothelial cells | es |
dc.subject | Human | es |
dc.subject | Hydroxytyrosol | es |
dc.subject | Inflammation | es |
dc.subject | Metabolites | es |
dc.subject | Mice | es |
dc.title | Effect of metabolites of hydroxytyrosol on protection against oxidative stress and inflammation in human endothelial cells | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.relation.projectID | 09-CVI-5007 | es |
dc.relation.projectID | ES-2012-056104 | es |
dc.relation.projectID | JCI-2012-13084 | es |
dc.relation.projectID | JAEDOC089 | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.jff.2016.12.033 | es |
dc.identifier.doi | 10.1016/j.jff.2016.12.033 | es |
dc.journaltitle | Journal of Functional Foods | es |
dc.publication.volumen | 29 | es |
dc.publication.initialPage | 238 | es |
dc.publication.endPage | 247 | es |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (CSIC) | es |