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Browsing Artículos (Bioquímica y Biología Molecular) by Author "Ayala Gómez, Antonio"
Now showing items 1-20 of 27
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Article
A Double-Blind, RCT Testing Beneficial Modulation of BDNF in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection?
Chui, D. H.; Marcellino, Massimiliano; Marotta, Francesco; Sweed, H.; Solimene, U.; Vignali, A. I.; Ayala Gómez, Antonio; Zerbinati, Nicola (JCDR, 2014)Introduction: The aim of this prospective study was to see whether LD-1227, a quality-controlled marine nutraceuticals shown ...
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Article
Advantages and Disadvantages of Apoptosis in the Aging Process
Argüelles Castilla, Sandro; Guerrero Castilla, Angélica; Cano Rodríguez, María Mercedes; Muñoz Pinto, Mario Faustino; Ayala Gómez, Antonio (Wiley-Blackwell, 2019)Researchers cannot predict as yet how long a human being can live. Life expectancy has been steadily increasing in the ...
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Article
Aging and Oxidative Stress Decrease Pineal Elongation Factor 2: In Vivo Protective Effect of Melatonin in Young Rats Treated With Cumene Hydroperoxide
Muñoz Pinto, Mario Faustino; Argüelles Castilla, Sandro; Cano Rodríguez, María Mercedes; Marotta, Francesco; Ayala Gómez, Antonio (Wiley-Blackwell, 2017)We studied the alterations of Elongation Factor 2 (eEF2) in the pineal gland of aged rats as well as the possible protective ...
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Article
Cell Tracking, Survival, and Differentiation Capacity of Adipose-Derived Stem Cells After Engraftment in Rat Tissue
Muñoz Pinto, Mario Faustino; Argüelles Castilla, Sandro; Guzmán Chozas, Matías; Guillén Sans, Remedios; Franco, Jaime M.; Pintor Toro, José A.; Cano Rodríguez, María Mercedes; Ayala Gómez, Antonio (Wiley-Blackwell, 2018)Adipose tissue is an important source of adipose derived stem cells (ADSCs). These cells have the potential of being used ...
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Article
Chronic Stress Alters the Expression Levels of Longevity-related Genes in the Rat Hippocampus
Sánchez Hidalgo, Ana C.; Muñoz Pinto, Mario Faustino; Herrera Carmona, Antonio José; Espinosa Oliva, Ana María; Stowell, Rianne; Ayala Gómez, Antonio; Machado, Alberto; Venero Recio, José Luis; Martínez de Pablos, Rocío (Elsevier, 2016)The molecular mechanisms underlying the negative effects of psychological stress on cellular stress during aging and ...
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Article
Dysregulation of the Hippo Pathway Signaling in Aging and Cancer
Yeung, Yiu To; Guerrero Castilla, Angelica; Cano Rodríguez, María Mercedes; Muñoz Pinto, Mario Faustino; Ayala Gómez, Antonio; Argüelles Castilla, Sandro (Elsevier, 2019)Human beings are facing emerging degenerative and cancer diseases, in large part, as a consequence of increased life ...
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Article
Effect of Age and Lipoperoxidation in Rat and Human Adipose Tissue-Derived Stem Cells
Muñoz Pinto, Mario Faustino; Argüelles Castilla, Sandro; Marotta, Francesco; Barbagallo, M.; Cano Rodríguez, María Mercedes; Ayala Gómez, Antonio (Hindawi, 2020)A wide range of clinical applications in regenerative medicine were opened decades ago with the discovery of adult stem ...
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Article
Effect of oxidative stress, produced by cumene hydroperoxide, on the various steps of protein synthesis. Modifications of elongation factor-2
Ayala Gómez, Antonio; Parrado Rubio, Juan; Bougria, Mohammed; Machado Quintana, Alberto (American Society for Biochemistry and Molecular Biology, 1996)We have studied the effect of oxidative stress on protein synthesis in rat liver. Cumene hydroperoxide (CH) was used as ...
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Article
Effect of VBC-1814/7J, a poly-phytocompound, on a non-infectious model of pharyngitis
Uemura, Junji; Nagpal, Ravinder K.; Zerbinati, Nicola; Marcellino, Massimiliano; Mohania, Dheeraj; Marotta, Francesco; He, Fang; Ayala Gómez, Antonio; Kasugai, Yasuhiro; Catanzaro, Roberto (Spandidos Publications, 2017)Pharyngitis presents as an inflammation of the oropharynx, and clinical examination often shows evidence of nasopharyngitis. ...
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Article
Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions
Argüelles Castilla, Sandro; Camandola, Simonetta; Cutler, Roy G.; Ayala Gómez, Antonio (Elsevier, 2013)Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) ...
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Article
Folic acid supplementation: some practical aspects
Cano Rodríguez, María Mercedes; Muñoz Pinto, Mario Faustino; Ayala Gómez, Antonio; Argüelles Castilla, Sandro (Federation of Anti-Aging Medicine Societies, 2012)Since 1956, when Harman first postulated the free radical theory of aging, numerous studies have been carried out to test ...
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Article
Immunolocalization of Substance P and NK-1 Receptor in ADIPOSE Stem Cells
Muñoz, Miguel; Muñoz Pinto, Mario Faustino; Ayala Gómez, Antonio (Wiley-Blackwell, 2017)Substance P (SP) is a neuropeptide belonging to the thachykinin peptide family. SP, after binding to its receptor, the ...
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Article
Impairment of mineralocorticoid receptor (MR)-dependent biological response by oxidative stress and aging
Piwien Pilipuk, Graciela; Ayala Gómez, Antonio; Machado de la Quintana, Alberto; Galigniana, Mario D. (American Society for Biochemistry and Molecular Biology, 2002)Acute and chronic treatments of mice with the gluta- thione-depleting agent, L-buthionine-(SR)-sulfoximine (BSO), impaired ...
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Article
In vitro and in Vivo Protection by Melatonin Against the Decline of Elongation Factor-2 Caused by Lipid Peroxidation: Preservation of Protein Synthesis
Argüelles Castilla, Sandro; Muñoz Pinto, Mario Faustino; Cano Rodríguez, María Mercedes; Machado Quintana, Alberto; Ayala Gómez, Antonio (Wiley-Blackwell, 2012)As organisms age, a considerable decrease in protein synthesis takes place in all tissues. Among the possible causes of ...
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Article
Interim report from a 2-year double-blind RCT testing fermented papaya preparation on immune enhancement, endothelial health and QOL in elderly adults
Lorenzetti, Aldo; Osato, Maki; He, Fang; Aperio, Cristiana; Ayala Gómez, Antonio; Rasulova, Saida; Barbagallo, Mario (2023-02-27)profile, and endothelial cell dysfunction. Indeed, increased generation of free radicals as well as immunosenescence are ...
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Article
Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal
Ayala Gómez, Antonio; Muñoz Pinto, Mario Faustino; Argüelles Castilla, Sandro (Hindawi Publishing Corporation, 2014)Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids ...
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Article
Mitochondrial toxins and neurodegenerative diseases
Ayala Gómez, Antonio; Venero Recio, José Luis; Cano, Josefina; Machado, Alberto (IMR Press, 2007)The selective loss of a particular subset of neurons is a common feature of neurodegenerative disorders. A failure in ...
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Article
Molecular Control of the Amount, Subcellular Location and Activity State of Translation Elongation Factor 2 (eEF-2) in Neurons Experiencing Stress
Argüelles Castilla, Sandro; Camandola, Simonetta; Hutchison, Emmette R.; Cutler, Roy G.; Ayala Gómez, Antonio (Eslsevier, 2013)Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery wherein it controls ...
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Article
Neutrophil-lymphocyte ratio and update conclusions from a 2-year double-blind rct testing fermented papaya preparation in healthy middle-aged/elderly subjects
Lorenzetti, Aldo; Ayala Gómez, Antonio; He, Fang; Aperio, Cristiana; Haghshenas, Leila; Osato, Maki; Marotta, Francesco (Functional Food Center, 2024-01-09)Background:T his study represents the second part of a 2-year interventional study in middle-aged /elderly healthy subjects ...
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Article
Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: A cohort study
Abilés, Jimena; Pérez de la Cruz, Antonio Jesús; Castaño, José García; Rodríguez Elvira, Manuel; Aguayo, Eduardo; Moreno Torres, Rosario; Llopis, Juan Emilio; Aranda, Pilar; Argüelles Castilla, Sandro; Ayala Gómez, Antonio; Machado Quintana, Alberto; Planells, Elena María (Springer Science + Business Media, 2006)Critically ill patients suffer from oxidative stress caused by reactive oxygen species (ROS) and reactive nitrogen species ...