Artículo
BRCA1 Accelerates CtIP-Mediated DNA-End Resection
Autor/es | Cruz García, Andrés
López Saavedra, Ana Huertas Sánchez, Pablo |
Departamento | Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2014 |
Fecha de depósito | 2019-02-08 |
Publicado en |
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Resumen | DNA-end resection is a highly regulated and critical
step in the response and repair of DNA double-strand
breaks. In higher eukaryotes, CtIP regulates resection
by integrating cellular signals via its posttranslationa ... DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher eukaryotes, CtIP regulates resection by integrating cellular signals via its posttranslational modifications and protein-protein interactions, including cell-cycle-controlled interaction with BRCA1. The role of BRCA1 in DNA-end resection is not clear. Here, we develop an assay to study DNA resection in higher eukaryotes at high resolution. We demonstrate that the BRCA1-CtIP interaction, albeit not essential for resection, modulates the speed at which this process takes place. |
Cita | Cruz García, A., López Saavedra, A. y Huertas Sánchez, P. (2014). BRCA1 Accelerates CtIP-Mediated DNA-End Resection. Cell Reports, 9, 451-459. |