idUS - Author profile: Huertas Sánchez, Pablo

Name	Huertas Sánchez, Pablo
Department	Genética
Knowledge area	Genética
Professional category	Profesor Titular de Universidad
E-mail	Request

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49
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PhD Thesis Molecular basis of Aicardi-Goutières syndrome Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Jimeno González, Sonia; Jimeno González, Sonia; Moó Bajo, Andrea; Moó Bajo, Andrea (2023) DNA is an essential molecule for the proper functioning of the cell that is constantly exposed to exogenous and endogenous ...
PhD Thesis Unraveling the connection between centrosomes and the DNA damage response Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Romero Balestra, Fernando; Romero Balestra, Fernando; Rodríguez Real, Guillermo; Rodríguez Real, Guillermo (2023) Centrosomes act as the major microtubule (MT) organizing centers (MTOC) in most animal cells. Structural or numerical defects in this organelle are associated with ...
PhD Thesis Non-canonical DNA structures in Double Strand Break repair Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Jimeno González, Sonia; Jimeno González, Sonia; Camarillo Daza, María Rosa; Camarillo Daza, María Rosa (2023) DNA double-strand breaks (DSBs) pose a serious threat to genome stability, so their proper repair is crucial for cell ...
Article N7-methylguanosine methylation of tRNAs regulates survival to stress in cancer García Vílchez, Raquel; García Vílchez, Raquel; Añazco Guenkova, Ana M.; Añazco Guenkova, Ana M.; López, Judith; López, Judith; Dietmann, Sabine; Dietmann, Sabine; Tomé, Mercedes; Tomé, Mercedes; Jimeno González, Sonia; Jimeno González, Sonia; Azkargorta, Mikel; Azkargorta, Mikel; Elortza, Félix; Elortza, Félix; Bárcena, Laura; Bárcena, Laura; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Blanco, Sandra; Blanco, Sandra (Springer Nature, 2023) Tumour progression and therapy tolerance are highly regulated and complex processes largely dependent on the plasticity ...
Article Centriolar Subdistal Appendages Promote Double-strand Break Repair Through Homologous Recombination Rodriguez Real, Guillermo; Rodriguez Real, Guillermo; Domínguez Calvo, Andrés; Domínguez Calvo, Andrés; Prados Carvajal, Rosario; Prados Carvajal, Rosario; Bayona Feliu, Aleix; Bayona Feliu, Aleix; Gomes Pereira, Sonia; Gomes Pereira, Sonia; Romero Balestra, Fernando; Romero Balestra, Fernando; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (1469-3178, 2023) The centrosome is a cytoplasmic organelle with roles in microtu-bule organization that has also been proposed to act as a ...
Article Multivalent Calixarene-Based Liposomes as Platforms for Gene and Drug Delivery Lebrón Romero, José Antonio; Lebrón Romero, José Antonio; López López, Manuel; López López, Manuel; García Calderón, Clara Beatriz; García Calderón, Clara Beatriz; Valle Rosado, Iván; Valle Rosado, Iván; Romero Balestra, Fernando; Romero Balestra, Fernando; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Rodik, Roman V; Rodik, Roman V; Kalchenko, Vitaly I.; Kalchenko, Vitaly I.; Bernal Pérez, Eva; Bernal Pérez, Eva; Moyá Morán, María Luisa; Moyá Morán, María Luisa; López-Cornejo, María del Pilar; López-Cornejo, María del Pilar; Ostos Marcos, Francisco José; Ostos Marcos, Francisco José (MDPI, 2021) The formation of calixarene-based liposomes was investigated, and the characterization of these nanostructures was carried ...
Article ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair Jimeno González, Sonia; Jimeno González, Sonia; Prados Carvajal, Rosario; Prados Carvajal, Rosario; Fernández Ávila, María Jesús; Fernández Ávila, María Jesús; Pinela Da Silva, Sonia Cristina; Pinela Da Silva, Sonia Cristina; Silvestris, Domenico Alessandro; Silvestris, Domenico Alessandro; Endara Coll, Martin; Endara Coll, Martin; Rodríguez Real, Guillermo; Rodríguez Real, Guillermo; Domingo Prim, Judit; Domingo Prim, Judit; Mejías Navarro, Fernando; Mejías Navarro, Fernando; Romero Franco, Amador; Romero Franco, Amador; Jimeno González, Silvia; Jimeno González, Silvia; Barroso, Sonia; Barroso, Sonia; Cesarini, Valeriana; Cesarini, Valeriana; Aguilera López, Andrés; Aguilera López, Andrés; Gallo, Angela; Gallo, Angela; Visa, Neus; Visa, Neus; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Nature Publishing Group, 2021) The maintenance of genomic stability requires the coordination of multiple cellular tasks upon the appearance of DNA ...
Article TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin Romero Balestra, Fernando; Romero Balestra, Fernando; Domínguez Calvo, Andrés; Domínguez Calvo, Andrés; Wolf, Benita; Wolf, Benita; Busso, Coralie; Busso, Coralie; Buff, Alizée; Buff, Alizée; Averink, Tessa; Averink, Tessa; Lipsanen Nyman, Marita; Lipsanen Nyman, Marita; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Rios Sánchez, Rosa M.; Rios Sánchez, Rosa M.; Gönczy, Pierre; Gönczy, Pierre (eLife Sciences Publications, 2021) TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor ...
Article The effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexes Camarillo Daza, María Rosa; Camarillo Daza, María Rosa; Jimeno González, Sonia; Jimeno González, Sonia; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Frontiers Media S.A., 2021) The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond ...
Article MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair Rivero Canalejo, Sabrina; Rivero Canalejo, Sabrina; Rodríguez Real, Guillermo; Rodríguez Real, Guillermo; Marín, Inés; Marín, Inés; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Wiley-Blackwell, 2021) The repair of DNA breaks takes place in the context of chromatin and thus involves the activity of chromatin remodelers. ...
Article CtIP-mediated Alternative mRNA Splicing Fine-tunes the DNA Damage Response Prados Carvajal, Rosario; Prados Carvajal, Rosario; Rodríguez Real, Guillermo; Rodríguez Real, Guillermo; Gutiérrez Pozo, Gabriel; Gutiérrez Pozo, Gabriel; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Cold Spring Harbor Laboratory Press, 2021) In order to survive to the exposure of DNA damaging agents, cells activate a complex response that coordinates the cellular ...
Article Cationic Single-Chained Surfactants with a Functional Group at the End of the Hydrophobic Tail DNA Compacting Efficiency Lebrón Romero, José Antonio; Lebrón Romero, José Antonio; López-Cornejo, María del Pilar; López-Cornejo, María del Pilar; García Dionisio, Elena; García Dionisio, Elena; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; García Calderón, Margarita; García Calderón, Margarita; Moyá Morán, María Luisa; Moyá Morán, María Luisa; Ostos Marcos, Francisco José; Ostos Marcos, Francisco José; López López, Manuel; López López, Manuel (Multidisciplinary Digital Publishing Institute (MDPI), 2021) The interaction between calf-thymus DNA, ctDNA, and various single-chained surfactants with different functional groups ...
Article The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair Jimeno González, Sonia; Jimeno González, Sonia; Romero Balestra, Fernando; Romero Balestra, Fernando; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Frontiers Media S.A., 2021) The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the ...
PhD Thesis Crosstalk between DNA end resection and RNA metabolism Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Prados Carvajal, Rosario; Prados Carvajal, Rosario (2020) DNA suffers thousands of lesions from exogenous and endogenous sources. Nevertheless, double-strand breaks (DSBs) are the ...
PhD Thesis Regulation of DNA end resection by cell stemness Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Checa Rodríguez, Cintia; Checa Rodríguez, Cintia (2020) The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) holds great potential for clinic ...
Article Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox Vítor, Alexandra C.; Vítor, Alexandra C.; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Legube, Gaëlle; Legube, Gaëlle; Almeida, Sérgio F. de; Almeida, Sérgio F. de (Frontiers Media, 2020) To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have ...
Article PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks Alonso de la Vega, Ignacio; Alonso de la Vega, Ignacio; Paz Cabrera, María Cristina; Paz Cabrera, María Cristina; Rother, Magdalena B; Rother, Magdalena B; Wiegant, Wouter W; Wiegant, Wouter W; Checa Rodríguez, Cintia; Checa Rodríguez, Cintia; Hernández Fernaud, Juan Ramón; Hernández Fernaud, Juan Ramón; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Freire, Raimundo; Freire, Raimundo; Attikum, Haico van; Attikum, Haico van; Smits, Veronique A J; Smits, Veronique A J (Oxford University Press, 2020) Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the ...
Article UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors Jachimowicz, Ron D.; Jachimowicz, Ron D.; Beleggia, Filippo; Beleggia, Filippo; Isensee, Jörg; Isensee, Jörg; Velpula, Bhagya Bhavana; Velpula, Bhagya Bhavana; Goergens, Jonas; Goergens, Jonas; Bustos, Matias A.; Bustos, Matias A.; Checa Rodríguez, Cintia; Checa Rodríguez, Cintia; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Elsevier, 2020) Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation ...
Article ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection Mejías Navarro, Fernando; Mejías Navarro, Fernando; Rodríguez Leal, Jesús M.; Rodríguez Leal, Jesús M.; Ramón, Javier; Ramón, Javier; Camarillo Daza, María Rosa; Camarillo Daza, María Rosa; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Public Library of Science, 2020) During repair of DNA double-strand breaks, resection of DNA ends influences how these lesions will be repaired. If resection ...
Article Metallo-Liposomes of Ruthenium Used as Promising Vectors of Genetic Material Lebrón Romero, José Antonio; Lebrón Romero, José Antonio; Ostos Marcos, Francisco José; Ostos Marcos, Francisco José; López López, Manuel; López López, Manuel; Moyá Morán, María Luisa; Moyá Morán, María Luisa; Sales, Carlos; Sales, Carlos; García, Encarnación; García, Encarnación; García Calderón, Clara Beatriz; García Calderón, Clara Beatriz; García Calderón, Margarita; García Calderón, Margarita; Peña Gómez, Mª José; Peña Gómez, Mª José; Valle Rosado, Iván; Valle Rosado, Iván; Romero Balestra, Fernando; Romero Balestra, Fernando; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; López-Cornejo, María del Pilar; López-Cornejo, María del Pilar (MDPI, 2020) Gene therapy is a therapeutic process consisting of the transport of genetic material into cells. The design and preparation ...
PhD Thesis Regulation of resection by chromatin associated proteins Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Mejías Navarro, Fernando; Mejías Navarro, Fernando (2019) La molécula de ADN está permanentemente expuesta a múltiples fuentes de daño que ponen en peligro la integridad genómica. ...
Article EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks Domingo Prim, Judit; Domingo Prim, Judit; Endara Coll, Martin; Endara Coll, Martin; Bonath, Franziska; Bonath, Franziska; Prados Carvajal, Rosario; Prados Carvajal, Rosario; Friedländer, Marc R.; Friedländer, Marc R.; Visa, Neus; Visa, Neus; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Jimeno González, Sonia; Jimeno González, Sonia (Nature Research, 2019) The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is ...
Article The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures Jimeno González, Sonia; Jimeno González, Sonia; Camarillo Daza, María Rosa; Camarillo Daza, María Rosa; Mejías Navarro, Fernando; Mejías Navarro, Fernando; Fernández Ávila, Mª Jesús; Fernández Ávila, Mª Jesús; Soria Bretones, Isabel; Soria Bretones, Isabel; Prados Carvajal, Rosario; Prados Carvajal, Rosario; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Elsevier, 2018) DNA breaks are complex lesions that can be repaired either by non-homologous end joining (NHEJ) or by homologous recombination ...
Article Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair Prados Carvajal, Rosario; Prados Carvajal, Rosario; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Gavish Izakson, Michal; Gavish Izakson, Michal; Bhavana Velpula, Bhagya; Bhavana Velpula, Bhagya; Elkon, Ran; Elkon, Ran (Oxford University Press, 2018) The DNA damage response (DDR) is an extensive signaling network that is robustly mobilized by DNA double-strand breaks ...
Article Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1 Hernández, Gonzalo; Hernández, Gonzalo; Ramirez, María José; Ramirez, María José; Minguillón, Jordi; Minguillón, Jordi; Quiles, Paco; Quiles, Paco; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Prados Carvajal, Rosario; Prados Carvajal, Rosario (Nature Publishing Group, 2018) BRCA1 is a tumor suppressor that regulates DNA repair by homologous recombination. Germline mutations in BRCA1 are associated ...
Article The ubiquitin E3/E4 ligase, UBE4A, fine-tunes protein ubiquitylation and accumulation at sites of DNA damage facilitating double-strand break repair Soria Bretones, Isabel; Soria Bretones, Isabel; Baranes Bachar, Keren; Baranes Bachar, Keren; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Levy Barda, Adva; Levy Barda, Adva; Oehler, Judith; Oehler, Judith (Elsevier, 2018) Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. ...
PhD Thesis New insights into CtIP protein: expression in breast cancer and regulation by sumoylation Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Soria Bretones, Isabel; Soria Bretones, Isabel (2017) Las roturas de doble cadena representan el tipo más nocivo entre todas las posibles lesiones que pueden ocurrir en el ADN, ...
PhD Thesis Identificación de nuevas proteínas que interaccionan con CtIP: Implicación de PRMT5 y CCAR2 en la resección del ADN Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; López Saavedra, Ana; López Saavedra, Ana (2017) DNA double-strand breaks (DSBs) represent the most cytotoxic DNA lesion that can arise from either endogenous and exogenous ...
PhD Thesis Control de la procesividad de la resección por las proteinas CTIP, BRCA1 y las topoisomerasas del tipo II Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Cruz García, Andrés; Cruz García, Andrés (2017) Las cadenas de ADN pueden sufrir roturas debido a la acción de agentes exógenos, principalmente mutágenos químicos o ...
Article Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer Rabinowicz, Noa; Rabinowicz, Noa; Mangala, Lingegowda S.; Mangala, Lingegowda S.; Brown, Kevin R.; Brown, Kevin R.; Checa Rodríguez, Cintia; Checa Rodríguez, Cintia; Castiel, Asher; Castiel, Asher; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Impact Journals, 2017) Advanced ovarian cancer is an incurable disease. Thus, novel therapies are required. We wished to identify new therapeutic ...
Article CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells Gómez Cabello, Daniel; Gómez Cabello, Daniel; Checa Rodríguez, Cintia; Checa Rodríguez, Cintia; Abad, María; Abad, María; Serrano, Manuel; Serrano, Manuel; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Elsevier, 2017) Acquired genomic instability is one of the major concerns for the clinical use of induced pluripotent stem cells (iPSCs). ...
Article DNA end resection requires constitutive sumoylation of CtIP by CBX4 Soria Bretones, Isabel; Soria Bretones, Isabel; Cepeda García, Cristina; Cepeda García, Cristina; Checa Rodríguez, Cintia; Checa Rodríguez, Cintia; Heyer, Vincent; Heyer, Vincent; Reina San Martín, Bernardo; Reina San Martín, Bernardo; Soutoglou, Evi; Soutoglou, Evi; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Nature Publishing Group, 2017) DNA breaks are complex DNA lesions that can be repaired by two alternative mechanisms: non-homologous end-joining and ...
PhD Thesis Regulación de la reparación de los cortes de doble cadena en el ADN: papel de la nedilación de proteínas Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Jimeno González, Sonia; Jimeno González, Sonia; Fernández Ávila, María Jesús; Fernández Ávila, María Jesús (2016) Las roturas de doble cadena del ADN son las lesiones más citotóxicas que pueden ocurrir en el ADN. Pueden ser reparadas ...
Article A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection López Saavedra, Ana; López Saavedra, Ana; Gómez Cabello, Daniel; Gómez Cabello, Daniel; Domínguez Sánchez, María Salud; Domínguez Sánchez, María Salud; Mejías Navarro, Fernando; Mejías Navarro, Fernando; Fernández Ávila, María Jesús; Fernández Ávila, María Jesús; Martínez Macías, María Isabel; Martínez Macías, María Isabel; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Nature Publishing Group, 2016) There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous ...
Article Speed matters: How subtle changes in DNA end resection rate affect repair Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Cruz García, Andrés; Cruz García, Andrés (Taylor & Francis, 2015) The contribution of BRCA1 (breast cancer 1) to the repair of broken DNA is well established, but its real role at the ...
Article The COP9 signalosome is vital for timely repair of DNA double-strand breaks Meir, Michal; Meir, Michal; Galanty, Yaron; Galanty, Yaron; Fernández Ávila, María Jesús; Fernández Ávila, María Jesús; Cruz García, Andrés; Cruz García, Andrés; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Oxford University Press, 2015) The DNA damage response is vigorously activated by DNA double-strand breaks (DSBs). The chief mobilizer of the DSB response ...
Article Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice Jimeno González, Sonia; Jimeno González, Sonia; Fernández Ávila, María Jesús; Fernández Ávila, María Jesús; Cruz García, Andrés; Cruz García, Andrés; Cepeda García, Cristina; Cepeda García, Cristina; Gómez Cabello, Daniel; Gómez Cabello, Daniel; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Oxford University Press, 2015) DNA double strand breaks are the most cytotoxic lesions that can occur on the DNA. They can be repaired by different ...
Presentation Sumoylation of CtIP controls DNA end resection Soria Bretones, Isabel; Soria Bretones, Isabel; Hernández Pérez, Santiago; Hernández Pérez, Santiago; Freire, Raimundo; Freire, Raimundo; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (2014) Double strand breaks (DSBs) can be repaired by two major mechanisms. Both ends can be simple re-joined with little or no ...
Article BRCA1 Accelerates CtIP-Mediated DNA-End Resection Cruz García, Andrés; Cruz García, Andrés; López Saavedra, Ana; López Saavedra, Ana; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Elsevier, 2014) DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher ...
Article Prognostic value of CtIP/RBBP8 expression in breast cancer Soria Bretones, Isabel; Soria Bretones, Isabel; Ruíz Borrego, Manuel; Ruíz Borrego, Manuel; Japón Rodríguez, Miguel Ángel; Japón Rodríguez, Miguel Ángel; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Wiley Open Access, 2013) CtIP/RBBP8 is a multifunctional protein involved in transcription, DNA replication, DNA repair by homologous recombination ...
Article Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination Muñoz Galván, Sandra; Muñoz Galván, Sandra; López Saavedra, Ana; López Saavedra, Ana; Jackson, Stephen P.; Jackson, Stephen P.; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Cortés Ledesma, Felipe; Aguilera López, Andrés; Aguilera López, Andrés (Oxford University Press, 2013) While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of ...
Article New tools to study DNA double-strand break repair pathway choice Gómez Cabello, Daniel; Gómez Cabello, Daniel; Jimeno González, Sonia; Jimeno González, Sonia; Fernández Ávila, María Jesús; Fernández Ávila, María Jesús; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (2013)
Article CtIP Mutations Cause Seckel and Jawad Syndromes Qvist, Per; Qvist, Per; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Jimeno González, Sonia; Jimeno González, Sonia; Nyegaard, Mette; Nyegaard, Mette; Hassan, Muhammad J.; Hassan, Muhammad J.; Jackson, Stephen P.; Jackson, Stephen P. (Public Library of Science, 2011) Seckel syndrome is a recessively inherited dwarfism disorder characterized by microcephaly and a unique head profile. ...
Article DNA resection in eukaryotes: deciding how to fix the break Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (Natural Research, 2010) DNA double-strand breaks are repaired by different mechanisms, including homologous recombination and nonhomologous ...
Article Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Jackson, Stephen P.; Jackson, Stephen P. (American Society for Biochemistry and Molecular Biology, 2009) In G0 and G1, DNA double strand breaks are repaired by nonhomologous end joining, whereas in S and G2, they are also repaired ...
Article CDK targets Sae2 to control DNA-end resection and homologous recombination Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Cortés Ledesma, Felipe; Sartori, Alessandro A.; Sartori, Alessandro A.; Aguilera López, Andrés; Aguilera López, Andrés; Jackson, Stephen P.; Jackson, Stephen P. (Nature Publishing Group, 2008) DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous ...
Article The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability González Aguilera, Cristina; González Aguilera, Cristina; Tous Rivera, Cristina; Tous Rivera, Cristina; Gómez González, Belén; Gómez González, Belén; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; Luna Varo, Rosa María; Luna Varo, Rosa María; Aguilera López, Andrés; Aguilera López, Andrés (American Society for Cell Biology, 2008) The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in ...
Article An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination Huertas Sánchez, Pablo; Huertas Sánchez, Pablo; García Rubio, María Luisa; García Rubio, María Luisa; Wellinger, Ralf Erik; Wellinger, Ralf Erik; Luna Varo, Rosa María; Luna Varo, Rosa María; Aguilera López, Andrés; Aguilera López, Andrés (American Society for Microbiology, 2006) THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. ...
PhD Thesis Papel del RNA en expresión genética y recombinación en Saccharomyces cerevisiae Aguilera López, Andrés; Aguilera López, Andrés; Huertas Sánchez, Pablo; Huertas Sánchez, Pablo (2004) La información necesaria para la supervivencia celular se encuentra codificada en el genoma. Cualquier proceso que conlleve ...

Author profile: Huertas Sánchez, Pablo

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