Data

NameHuertas Sánchez, Pablo
DepartmentGenética
Knowledge areaGenética
Professional categoryProfesor Titular de Universidad
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  Statistics

  • Items

    38

  • Visits

    3969

  • Downloads

    3814

  Publications

 

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TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin

Romero Balestra, Fernando; Domínguez Calvo, Andrés; Wolf, Benita; Busso, Coralie; Buff, Alizée; Averink, Tessa; Lipsanen Nyman, Marita; Huertas Sánchez, Pablo; Rios Sánchez, Rosa M.; Gönczy, Pierre (eLife Sciences Publications, 2021-01-01)
TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor ...
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MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair

Rivero Canalejo, Sabrina; Rodríguez Real, Guillermo; Marín, Inés; Huertas Sánchez, Pablo (Wiley-Blackwell, 2021-01-01)
The repair of DNA breaks takes place in the context of chromatin and thus involves the activity of chromatin remodelers. ...
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The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair

Jimeno González, Sonia; Romero Balestra, Fernando; Huertas Sánchez, Pablo (Frontiers Media S.A., 2021-01-01)
The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the ...
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Cationic Single-Chained Surfactants with a Functional Group at the End of the Hydrophobic Tail DNA Compacting Efficiency

Lebrón Romero, José Antonio; López-Cornejo, María del Pilar; García Dionisio, Elena; Huertas Sánchez, Pablo; García Calderón, Margarita; Moyá Morán, María Luisa; Ostos Marcos, Francisco José; López López, Manuel (Multidisciplinary Digital Publishing Institute (MDPI), 2021-01-01)
The interaction between calf-thymus DNA, ctDNA, and various single-chained surfactants with different functional groups ...
PhD Thesis
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Crosstalk between DNA end resection and RNA metabolism

Huertas Sánchez, Pablo; Prados Carvajal, Rosario (2020-01-23)
DNA suffers thousands of lesions from exogenous and endogenous sources. Nevertheless, double-strand breaks (DSBs) are the ...
PhD Thesis
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Regulation of DNA end resection by cell stemness

Huertas Sánchez, Pablo; Checa Rodríguez, Cintia (2020-01-20)
The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) holds great potential for clinic ...
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ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection

Mejías Navarro, Fernando; Rodríguez Leal, Jesús M.; Ramón, Javier; Camarillo Daza, María Rosa; Huertas Sánchez, Pablo (Public Library of Science, 2020-01-01)
During repair of DNA double-strand breaks, resection of DNA ends influences how these lesions will be repaired. If resection ...
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Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox

Vítor, Alexandra C.; Huertas Sánchez, Pablo; Legube, Gaëlle; Almeida, Sérgio F. de (Frontiers Media, 2020-01-01)
To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have ...
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Metallo-Liposomes of Ruthenium Used as Promising Vectors of Genetic Material

Lebrón Romero, José Antonio; Ostos Marcos, Francisco José; López López, Manuel; Moyá Morán, María Luisa; Sales, Carlos; García, Encarnación; García Calderón, Clara Beatriz; García Calderón, Margarita; Peña Gómez, Mª José; Valle Rosado, Iván; Romero Balestra, Fernando; Huertas Sánchez, Pablo; López Cornejo, Pilar (MDPI, 2020-01-01)
Gene therapy is a therapeutic process consisting of the transport of genetic material into cells. The design and preparation ...
PhD Thesis
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Regulation of resection by chromatin associated proteins

Huertas Sánchez, Pablo; Mejías Navarro, Fernando (2019-05-24)
La molécula de ADN está permanentemente expuesta a múltiples fuentes de daño que ponen en peligro la integridad genómica. ...
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EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks

Domingo Prim, Judit; Endara Coll, Martin; Bonath, Franziska; Prados Carvajal, Rosario; Friedländer, Marc R.; Visa, Neus; Huertas Sánchez, Pablo; Jimeno González, Sonia (Nature Research, 2019-01-01)
The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is ...
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Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair

Prados Carvajal, Rosario; Huertas Sánchez, Pablo; Gavish Izakson, Michal; Bhavana Velpula, Bhagya; Elkon, Ran (Oxford University Press, 2018-01-01)
The DNA damage response (DDR) is an extensive signaling network that is robustly mobilized by DNA double-strand breaks ...
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The ubiquitin E3/E4 ligase, UBE4A, fine-tunes protein ubiquitylation and accumulation at sites of DNA damage facilitating double-strand break repair

Soria Bretones, Isabel; Baranes Bachar, Keren; Huertas Sánchez, Pablo; Levy Barda, Adva; Oehler, Judith (Elsevier, 2018-01-01)
Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. ...
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The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures

Jimeno González, Sonia; Camarillo Daza, María Rosa; Mejías Navarro, Fernando; Fernández Ávila, Mª Jesús; Soria Bretones, Isabel; Prados Carvajal, Rosario; Huertas Sánchez, Pablo (Elsevier, 2018-01-01)
DNA breaks are complex lesions that can be repaired either by non-homologous end joining (NHEJ) or by homologous recombination ...
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Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1

Hernández, Gonzalo; Ramirez, María José; Minguillón, Jordi; Quiles, Paco; Huertas Sánchez, Pablo; Prados Carvajal, Rosario (Nature Publishing Group, 2018-01-01)
BRCA1 is a tumor suppressor that regulates DNA repair by homologous recombination. Germline mutations in BRCA1 are associated ...
PhD Thesis
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New insights into CtIP protein: expression in breast cancer and regulation by sumoylation

Huertas Sánchez, Pablo; Soria Bretones, Isabel (2017-09-22)
Las roturas de doble cadena representan el tipo más nocivo entre todas las posibles lesiones que pueden ocurrir en el ADN, ...
PhD Thesis
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Identificación de nuevas proteínas que interaccionan con CtIP: Implicación de PRMT5 y CCAR2 en la resección del ADN

Huertas Sánchez, Pablo; López Saavedra, Ana (2017-06-06)
DNA double-strand breaks (DSBs) represent the most cytotoxic DNA lesion that can arise from either endogenous and exogenous ...
PhD Thesis
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Control de la procesividad de la resección por las proteinas CTIP, BRCA1 y las topoisomerasas del tipo II

Huertas Sánchez, Pablo; Cruz García, Andrés (2017-01-16)
Las cadenas de ADN pueden sufrir roturas debido a la acción de agentes exógenos, principalmente mutágenos químicos o ...
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CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells

Gómez Cabello, Daniel; Checa Rodríguez, Cintia; Abad, María; Serrano, Manuel; Huertas Sánchez, Pablo (Elsevier, 2017-01-01)
Acquired genomic instability is one of the major concerns for the clinical use of induced pluripotent stem cells (iPSCs). ...
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DNA end resection requires constitutive sumoylation of CtIP by CBX4

Soria Bretones, Isabel; Cepeda García, Cristina; Checa Rodríguez, Cintia; Heyer, Vincent; Reina San Martín, Bernardo; Soutoglou, Evi; Huertas Sánchez, Pablo (Nature Publishing Group, 2017-01-01)
DNA breaks are complex DNA lesions that can be repaired by two alternative mechanisms: non-homologous end-joining and ...
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Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer

Rabinowicz, Noa; Mangala, Lingegowda S.; Brown, Kevin R.; Checa Rodríguez, Cintia; Castiel, Asher; Huertas Sánchez, Pablo (Impact Journals, 2017-01-01)
Advanced ovarian cancer is an incurable disease. Thus, novel therapies are required. We wished to identify new therapeutic ...
PhD Thesis
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Regulación de la reparación de los cortes de doble cadena en el ADN: papel de la nedilación de proteínas

Huertas Sánchez, Pablo; Jimeno González, Sonia; Fernández Ávila, María Jesús (2016-07-14)
Las roturas de doble cadena del ADN son las lesiones más citotóxicas que pueden ocurrir en el ADN. Pueden ser reparadas ...
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A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection

López Saavedra, Ana; Gómez Cabello, Daniel; Domínguez Sánchez, María Salud; Mejías Navarro, Fernando; Fernández Ávila, María Jesús; Martínez Macías, María Isabel; Huertas Sánchez, Pablo (Nature Publishing Group, 2016-01-01)
There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous ...
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The COP9 signalosome is vital for timely repair of DNA double-strand breaks

Meir, Michal; Galanty, Yaron; Fernández Ávila, María Jesús; Cruz García, Andrés; Huertas Sánchez, Pablo (Oxford University Press, 2015-01-01)
The DNA damage response is vigorously activated by DNA double-strand breaks (DSBs). The chief mobilizer of the DSB response ...
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Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice

Jimeno González, Sonia; Fernández Ávila, María Jesús; Cruz García, Andrés; Cepeda García, Cristina; Gómez Cabello, Daniel; Huertas Sánchez, Pablo (Oxford University Press, 2015-01-01)
DNA double strand breaks are the most cytotoxic lesions that can occur on the DNA. They can be repaired by different ...
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Speed matters: How subtle changes in DNA end resection rate affect repair

Huertas Sánchez, Pablo; Cruz García, Andrés (Taylor & Francis, 2015-01-01)
The contribution of BRCA1 (breast cancer 1) to the repair of broken DNA is well established, but its real role at the ...
Presentation
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Sumoylation of CtIP controls DNA end resection

Soria Bretones, Isabel; Hernández Pérez, Santiago; Freire, Raimundo; Huertas Sánchez, Pablo (2014-08-01)
Double strand breaks (DSBs) can be repaired by two major mechanisms. Both ends can be simple re-joined with little or no ...
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BRCA1 Accelerates CtIP-Mediated DNA-End Resection

Cruz García, Andrés; López Saavedra, Ana; Huertas Sánchez, Pablo (Elsevier, 2014-01-01)
DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher ...
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Prognostic value of CtIP/RBBP8 expression in breast cancer

Soria Bretones, Isabel; Ruíz Borrego, Manuel; Japón Rodríguez, Miguel Ángel; Huertas Sánchez, Pablo (Wiley Open Access, 2013-01-01)
CtIP/RBBP8 is a multifunctional protein involved in transcription, DNA replication, DNA repair by homologous recombination ...
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Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination

Muñoz Galván, Sandra; López Saavedra, Ana; Jackson, Stephen P.; Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Aguilera López, Andrés (Oxford University Press, 2013-01-01)
While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of ...
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New tools to study DNA double-strand break repair pathway choice

Gómez Cabello, Daniel; Jimeno González, Sonia; Fernández Ávila, María Jesús; Huertas Sánchez, Pablo (2013-01-01)
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CtIP Mutations Cause Seckel and Jawad Syndromes

Qvist, Per; Huertas Sánchez, Pablo; Jimeno González, Sonia; Nyegaard, Mette; Hassan, Muhammad J.; Jackson, Stephen P. (Public Library of Science, 2011-01-01)
Seckel syndrome is a recessively inherited dwarfism disorder characterized by microcephaly and a unique head profile. ...
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DNA resection in eukaryotes: deciding how to fix the break

Huertas Sánchez, Pablo (Natural Research, 2010-01-01)
DNA double-strand breaks are repaired by different mechanisms, including homologous recombination and nonhomologous ...
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Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

Huertas Sánchez, Pablo; Jackson, Stephen P. (American Society for Biochemistry and Molecular Biology, 2009-01-01)
In G0 and G1, DNA double strand breaks are repaired by nonhomologous end joining, whereas in S and G2, they are also repaired ...
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CDK targets Sae2 to control DNA-end resection and homologous recombination

Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Sartori, Alessandro A.; Aguilera López, Andrés; Jackson, Stephen P. (Nature Publishing Group, 2008-01-01)
DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous ...
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The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability

González Aguilera, Cristina; Tous Rivera, Cristina; Gómez González, Belén; Huertas Sánchez, Pablo; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Cell Biology, 2008-01-01)
The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in ...
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An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination

Huertas Sánchez, Pablo; García Rubio, María Luisa; Wellinger, Ralf Erik; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Microbiology, 2006-01-01)
THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. ...
PhD Thesis
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Papel del RNA en expresión genética y recombinación en Saccharomyces cerevisiae

Aguilera López, Andrés; Huertas Sánchez, Pablo (2004-01-01)
La información necesaria para la supervivencia celular se encuentra codificada en el genoma. Cualquier proceso que conlleve ...