Artículo
Multivalent Calixarene-Based Liposomes as Platforms for Gene and Drug Delivery
Autor/es | Lebrón Romero, José Antonio
López López, Manuel García Calderón, Clara Beatriz Valle Rosado, Iván Romero Balestra, Fernando Huertas Sánchez, Pablo Rodik, Roman V Kalchenko, Vitaly I. Bernal Pérez, Eva Moyá Morán, María Luisa López-Cornejo, María del Pilar Ostos Marcos, Francisco José |
Departamento | Universidad de Sevilla. Departamento de Química Física Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2021-08 |
Fecha de depósito | 2021-08-30 |
Publicado en |
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Resumen | The formation of calixarene-based liposomes was investigated, and the characterization of these nanostructures was carried out using several techniques. Four amphiphilic calixarenes were used. The length of the hydrophobic ... The formation of calixarene-based liposomes was investigated, and the characterization of these nanostructures was carried out using several techniques. Four amphiphilic calixarenes were used. The length of the hydrophobic chains attached to the lower rim as well as the nature of the polar group present in the upper rim of the calixarenes were varied. The lipid bilayer was formed with one calixarene and with the phospholipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE. The cytotoxicity of the liposomes for various cell lines was also studied. From the results obtained, the liposomes formed with the least cytotoxic calixarene, (TEAC12)4, were used as nanocarriers of both nucleic acids and the antineoplastic drug doxorubicin, DOX. Results showed that (TEAC12)4/DOPE/p-EGFP-C1 lipoplexes, of a given composition, can transfect the genetic material, although the transfection efficiency substantially increases in the presence of an additional amount of DOPE as coadjuvant. On the other hand, the (TEAC12)4/DOPE liposomes present a high doxorubicin encapsulation efficiency, and a slow controlled release, which could diminish the side effects of the drug. |
Identificador del proyecto | (FQM-206, FQM-274, and PY20-01234)
(PP2019/00000748), RTI2018-100692-B-100; P18-RT-1271; PI18-0005-2018; VI-PP AY.SUPLEM2019; RYC-2015-18670 10.13039/501100011033 (P.H.) R+D+I grant PID2019-104195G |
Cita | Lebrón Romero, J.A., López López, M., García Calderón, C.B., Valle Rosado, I., Romero Balestra, F., Huertas Sánchez, P.,...,Ostos Marcos, F.J. (2021). Multivalent Calixarene-Based Liposomes as Platforms for Gene and Drug Delivery. Pharmaceutics, 13 (8), 1250. |
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pubpharmaceutics-13-01250-v2.pdf | 7.740Mb | [PDF] | Ver/ | |