Artículo
Toxic Effects of the Cylindrospermopsin and Chlorpyrifos Combination on the Differentiated SH-SY5Y Human Neuroblastoma Cell Line
Autor/es | Hinojosa, María G.
Gutiérrez-Praena, Daniel López Martín, Sergio Prieto Ortega, Ana Isabel Moreno Onorato, Francisco Javier Jos Gallego, Ángeles Mencía Cameán Fernández, Ana María |
Departamento | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal Universidad de Sevilla. Departamento de Biología Celular |
Fecha de publicación | 2023 |
Fecha de depósito | 2023-11-20 |
Publicado en |
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Resumen | Due to climate change and anthropogenic activities, the levels of pollution of aquatic and terrestrial environments have increased in the last decades. In this sense, the rise of cyanobacterial blooms, which release secondary ... Due to climate change and anthropogenic activities, the levels of pollution of aquatic and terrestrial environments have increased in the last decades. In this sense, the rise of cyanobacterial blooms, which release secondary metabolites with toxic properties, and the global use of pesticides for agricultural purposes have a negative impact on ecosystems. Thus, it would be interesting to study the concomitance of both types of toxicants in the same sample, since it is possible that they appear together. The aim of the present work was to state the effects of the interaction between the cyanotoxin cylindrospermopsin and the pesticide chlorpyrifos in differentiated SH-SY5Y neuronal cells to assess how they could affect the nervous system. To this end, cytotoxicity, morphological, and acetylcholinesterase activity studies were performed during 24 and 48 h. The results revealed a concentration-dependent decrease in viability and interaction between both toxicants, together with clear signs of apoptosis and necrosis induction. In this sense, different stages on the differentiation process would lead to differences in the toxicity exerted by the compounds both isolated as in combination, which it is not observed in non-differentiated cells. Additionally, the acetylcholinesterase activity appeared not to be affected, which is a clear difference compared to non-differentiated cells. These results show the importance of studying not only the toxicants themselves, but also in combination, to assess their possible effects in a more realistic scenario. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España |
Identificador del proyecto | PID 2019-104890RB-I00 |
Cita | Hinojosa, M.G., Gutiérrez-Praena, D., López Martín, S., Prieto Ortega, A.I., Moreno Onorato, F.J., Jos Gallego, Á.M. y Cameán Fernández, A.M. (2023). Toxic Effects of the Cylindrospermopsin and Chlorpyrifos Combination on the Differentiated SH-SY5Y Human Neuroblastoma Cell Line. Toxicon, 227, 107091. https://doi.org/10.1016/j.toxicon.2023.107091. |
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