dc.creator | Martínez de Pablos, Rocío | es |
dc.creator | Fernández Villarán, Ruth | es |
dc.creator | Argüelles Castilla, Sandro | es |
dc.creator | Herrera Carmona, Antonio José | es |
dc.creator | Venero Recio, José Luis | es |
dc.creator | Ayala Gómez, Antonio | es |
dc.date.accessioned | 2019-02-19T08:54:55Z | |
dc.date.available | 2019-02-19T08:54:55Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Martínez de Pablos, R., Fernández Villarán, R., Argüelles Castilla, S., Herrera Carmona, A.J., Venero Recio, J.L. y Ayala Gómez, A. (2006). Stress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortex. Journal of Neuroscience, 26 (21), 5709-5719. | |
dc.identifier.issn | 1529-2401 | es |
dc.identifier.uri | https://hdl.handle.net/11441/83199 | |
dc.description.abstract | Inflammation could be involved in some neurodegenerative disorders that accompany signs of inflammation. However, because sensitivity to inflammation is not equal in all brain structures, a direct relationship is not clear. Our aim was to test whether some physiological circumstances, such as stress, could enhance susceptibility to inflammation in the prefrontal cortex (PFC), which shows a relative resistance to inflammation. PFC is important in many brain functions and is a target for some neurodegenerative diseases. We induced an inflammatory process by a single intracortical injection of 2 μg of lipopolysaccharide (LPS), a potent proinflammogen, in nonstressed and stressed rats. We evaluated the effect of our treatment on inflammatory markers, neuronal populations, BDNF expression, and behavior of several mitogen-activated protein (MAP) kinases and the transcription factor cAMP response element-binding protein. Stress strengthens the changes induced by LPS injection: microglial activation and proliferation with an increase in the levels of the proinflammatory cytokine tumor necrosis factor-α; loss of cells such as astroglia, seen as loss of glial fibrillary acidic protein immunoreactivity, and neurons, studied by neuronal-specific nuclear protein immunohistochemistry and GAD67 and NMDA receptor 1A mRNAs expression by in situ hybridization. A significant increase in the BDNF mRNA expression and modifications in the levels of MAP kinase phosphorylation were also found. In addition, we observed a protective effect from RU486 [mifepristone (11β-[p-(dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one)], a potent inhibitor of the glucocorticoid receptor activation. All of these data show a synergistic effect between inflammation and stress, which could explain the relationship described between stress and some neurodegenerative pathologies. | es |
dc.description.sponsorship | España,Ministerio de Educación y Ciencia Grants SAF2002-01952 and SAF2004-06601 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Society for Neuroscience | es |
dc.relation.ispartof | Journal of Neuroscience, 26 (21), 5709-5719. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | prefrontal cortex | es |
dc.subject | stress | es |
dc.subject | inflammation | es |
dc.subject | neuronal death | es |
dc.subject | BDNF | es |
dc.subject | MAP kinases | es |
dc.title | Stress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortex | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.projectID | Grants SAF2002-01952 and SAF2004-06601 | es |
dc.relation.publisherversion | http://dx.doi.org//10.1523/JNEUROSCI.0802-06.2006 | es |
dc.identifier.doi | doi.org/10.1523/JNEUROSCI.0802-06.2006 | es |
idus.format.extent | 10 p. | es |
dc.journaltitle | Journal of Neuroscience | es |
dc.publication.volumen | 26 | es |
dc.publication.issue | 21 | es |
dc.publication.initialPage | 5709 | es |
dc.publication.endPage | 5719 | es |
dc.contributor.funder | Ministerio de Educación y Ciencia (MEC). España | |