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Artículo
BRCA1 Accelerates CtIP-Mediated DNA-End Resection
dc.creator | Cruz García, Andrés | es |
dc.creator | López Saavedra, Ana | es |
dc.creator | Huertas Sánchez, Pablo | es |
dc.date.accessioned | 2019-02-08T12:58:20Z | |
dc.date.available | 2019-02-08T12:58:20Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Cruz García, A., López Saavedra, A. y Huertas Sánchez, P. (2014). BRCA1 Accelerates CtIP-Mediated DNA-End Resection. Cell Reports, 9, 451-459. | |
dc.identifier.issn | 2211-1247 | es |
dc.identifier.uri | https://hdl.handle.net/11441/82770 | |
dc.description.abstract | DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher eukaryotes, CtIP regulates resection by integrating cellular signals via its posttranslational modifications and protein-protein interactions, including cell-cycle-controlled interaction with BRCA1. The role of BRCA1 in DNA-end resection is not clear. Here, we develop an assay to study DNA resection in higher eukaryotes at high resolution. We demonstrate that the BRCA1-CtIP interaction, albeit not essential for resection, modulates the speed at which this process takes place. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Cell Reports, 9, 451-459. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | BRCA1 Accelerates CtIP-Mediated DNA-End Resection | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.celrep.2014.08.076 | es |
dc.identifier.doi | 10.1016/j.celrep.2014.08.076 | es |
idus.format.extent | 9 p. | es |
dc.journaltitle | Cell Reports | es |
dc.publication.volumen | 9 | es |
dc.publication.initialPage | 451 | es |
dc.publication.endPage | 459 | es |