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Zn2+ chelation by serum albumin improves hexameric Zn2+ -insulin dissociation into monomers after exocytosis

 

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Opened Access Zn2+ chelation by serum albumin improves hexameric Zn2+ -insulin dissociation into monomers after exocytosis
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Author: Pertusa, José A. G.
León Quinto, Trinidad
Berná, Genoveva
Tejedo Huamán, Juan Rigoberto
Hmadcha, Abdelkrim
Bedoya Bergua, Francisco Javier
Martín, Franz
Soria Escoms, Bernat
Date: 2017
Published in: PLoS ONE, 12, 1-16.
Document type: Article
Abstract: β-cells release hexameric Zn2+-insulin into the extracellular space, but monomeric Zn2+-free insulin appears to be the only biologically active form. The mechanisms implicated in dissociation of the hexamer remain unclear, but they seem to be Zn2+...
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Cite: Pertusa, J.A.G., León Quinto, T., Berná, G., Tejedo Huamán, J.R., Hmadcha, A., Bedoya Bergua, F.J.,...,Soria Escoms, B. (2017). Zn2+ chelation by serum albumin improves hexameric Zn2+ -insulin dissociation into monomers after exocytosis. PLoS ONE, 12, 1-16.
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Format: PDF

URI: https://hdl.handle.net/11441/81135

DOI: 10.1371/journal.pone.0187547

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