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Scutoids are a geometrical solution to three-dimensional packing of epithelia


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Opened Access Scutoids are a geometrical solution to three-dimensional packing of epithelia

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Author: Gómez Gálvez, Pedro
Vicente Munuera, Pablo
Tagua, Antonio
Forja, Cristina
Castro Rodríguez, Ana María
Grima Ruiz, Clara Isabel
Bermúdez Gallardo, Marina
Escudero Cuadrado, Luis María
Márquez Pérez, Alberto
Department: Universidad de Sevilla. Departamento de Biología Celular
Universidad de Sevilla. Departamento de Matemática Aplicada I (ETSII)
Date: 2018
Published in: Nature Communications, 9 (2960.), 1-14.
Document type: Article
Abstract: As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis. This phenomenon forces cells to have different neighbours in their basal and apical surfaces. As a consequence, epithelial cells adopt a novel shape that we term “scutoid”. The detailed analysis of diverse tissues confirms that generation of apico-basal intercalations between cells is a common feature during morphogenesis. Using biophysical arguments, we propose that scutoids make possible the minimization of the tissue energy and stabilize three-dimensional packing. Hence, we conclude that scutoids are one of nature's solutions to achieve epithelial bending. Our findings pave the way to understand the three-dimensional organization of epithelial organs.
Cite: Gómez Gálvez, P., Vicente Munuera, P., Tagua, A., Forja, C., Castro Rodríguez, A.M., Grima Ruiz, C.I.,...,Márquez Pérez, A. (2018). Scutoids are a geometrical solution to three-dimensional packing of epithelia. Nature Communications, 9 (2960.), 1-14.
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DOI: 10.1038/s41467-018-05376-1

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