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dc.contributor.advisor
dc.creatorGómez Gálvez, Pedroes
dc.creatorVicente Munuera, Pabloes
dc.creatorTagua Jáñez, Antonioes
dc.creatorForja Barbosa, Cristinaes
dc.creatorCastro Rodríguez, Ana Maríaes
dc.creatorLetrán, Martaes
dc.creatorGrima Ruiz, Clara Isabeles
dc.creatorBermúdez Gallardo, Marinaes
dc.creatorSerrano Pérez-Higueras, Óscares
dc.creatorMárquez Pérez, Alberto
dc.creatorEscudero Cuadrado, Luis María
dc.date.accessioned2018-08-10T08:15:02Z
dc.date.available2018-08-10T08:15:02Z
dc.date.issued2018
dc.identifier.issn2041-1723es
dc.identifier.urihttps://hdl.handle.net/11441/77986
dc.description.abstractAs animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis. This phenomenon forces cells to have different neighbours in their basal and apical surfaces. As a consequence, epithelial cells adopt a novel shape that we term “scutoid”. The detailed analysis of diverse tissues confirms that generation of apico-basal intercalations between cells is a common feature during morphogenesis. Using biophysical arguments, we propose that scutoids make possible the minimization of the tissue energy and stabilize three-dimensional packing. Hence, we conclude that scutoids are one of nature's solutions to achieve epithelial bending. Our findings pave the way to understand the three-dimensional organization of epithelial organs.es
dc.description.sponsorshipEspaña Ministerio de Ciencia y Tecnología BFU2013-48988-C2-1-P and BFU2016-80797es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherNature Publishing Groupes
dc.relation.ispartofNature Communications, 9 (2960), 1-14.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleScutoids are a geometrical solution to three-dimensional packing of epitheliaes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Biología Celulares
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Matemática Aplicada I (ETSII)es
dc.relation.projectIDBFU2013-48988-C2-1-Pes
dc.relation.projectIDBFU2016-80797es
dc.relation.publisherversionhttp://dx.doi.org/10.1038/s41467-018-05376-1es
dc.identifier.doi10.1038/s41467-018-05376-1es
idus.format.extent14 p.es
dc.journaltitleNature Communicationses
dc.publication.volumen9es
dc.publication.issue2960.es
dc.publication.initialPage1es
dc.publication.endPage14es
dc.contributor.funderMinisterio de Ciencia y Tecnología (MCYT). España

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