Artículo
Scutoids are a geometrical solution to three-dimensional packing of epithelia
Autor/es | Gómez Gálvez, Pedro
Vicente Munuera, Pablo Tagua Jáñez, Antonio Forja Barbosa, Cristina Castro Rodríguez, Ana María Letrán, Marta Grima Ruiz, Clara Isabel Bermúdez Gallardo, Marina Serrano Pérez-Higueras, Óscar Márquez Pérez, Alberto Escudero Cuadrado, Luis María |
Director | |
Departamento | Universidad de Sevilla. Departamento de Biología Celular Universidad de Sevilla. Departamento de Matemática Aplicada I (ETSII) |
Fecha de publicación | 2018 |
Fecha de depósito | 2018-08-10 |
Publicado en |
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Premios | Premio Anual Publicación Científica Destacada de la US. Facultad de Biología |
Resumen | As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of ... As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis. This phenomenon forces cells to have different neighbours in their basal and apical surfaces. As a consequence, epithelial cells adopt a novel shape that we term “scutoid”. The detailed analysis of diverse tissues confirms that generation of apico-basal intercalations between cells is a common feature during morphogenesis. Using biophysical arguments, we propose that scutoids make possible the minimization of the tissue energy and stabilize three-dimensional packing. Hence, we conclude that scutoids are one of nature's solutions to achieve epithelial bending. Our findings pave the way to understand the three-dimensional organization of epithelial organs. |
Agencias financiadoras | Ministerio de Ciencia y Tecnología (MCYT). España |
Identificador del proyecto | BFU2013-48988-C2-1-P
BFU2016-80797 |
Cita | Gómez Gálvez, P., Vicente Munuera, P., Tagua Jáñez, A., Forja Barbosa, C., Castro Rodríguez, A.M., Letrán, M.,...,Escudero Cuadrado, L.M. (2018). Scutoids are a geometrical solution to three-dimensional packing of epithelia. Nature Communications, 9 (2960.), 1-14. |
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