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Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes

 

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Opened Access Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes
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Author: Hernández Allés, Santiago
Benedí, Vicente J.
Martínez Martínez, Luis
Pascual Hernández, Álvaro
Aguilar, Alicia
Tomás, Juan M.
Albertí, Sebastián
Department: Universidad de Sevilla. Departamento de Microbiología
Date: 1999-01-01
Published in: Antimicrobial Agents and Chemotherapy, 43 (4), 937-939.
Document type: Article
Abstract: We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to cefoxitin in Klebsiella pneumoniae. This mechanism also operates in vivo: of 13 porin-deficient cefoxitin-resistant clinical isolates of K. pneumoniae, 4 presented ISs in their ompK36 gene.
Cite: Hernández Allés, S., Benedí, V.J., Martínez Martínez, L., Pascual Hernández, Á., Aguilar, A., Tomás, J.M. y Albertí, S. (1999). Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes. Antimicrobial Agents and Chemotherapy, 43 (4), 937-939.
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URI: http://hdl.handle.net/11441/64839

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