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Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes

dc.creatorHernández Allés, Santiagoes
dc.creatorBenedí, Vicente J.es
dc.creatorMartínez Martínez, Luises
dc.creatorPascual Hernández, Álvaroes
dc.creatorAguilar, Aliciaes
dc.creatorTomás, Juan M.es
dc.creatorAlbertí, Sebastiánes
dc.date.accessioned2017-09-28T15:51:04Z
dc.date.available2017-09-28T15:51:04Z
dc.date.issued1999-01-01
dc.identifier.citationHernández Allés, S., Benedí, V.J., Martínez Martínez, L., Pascual Hernández, Á., Aguilar, A., Tomás, J.M. y Albertí, S. (1999). Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes. Antimicrobial Agents and Chemotherapy, 43 (4), 937-939.
dc.identifier.issn0066-4804 (impreso)es
dc.identifier.issn1098-6596 (electrónico)es
dc.identifier.urihttp://hdl.handle.net/11441/64839
dc.description.abstractWe have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to cefoxitin in Klebsiella pneumoniae. This mechanism also operates in vivo: of 13 porin-deficient cefoxitin-resistant clinical isolates of K. pneumoniae, 4 presented ISs in their ompK36 gene.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Society for Microbiologyes
dc.relation.ispartofAntimicrobial Agents and Chemotherapy, 43 (4), 937-939.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleDevelopment of resistance during antimicrobial therapy caused by insertion sequence interruption of porin geneses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Microbiologíaes
idus.format.extent3 p.es
dc.journaltitleAntimicrobial Agents and Chemotherapyes
dc.publication.volumen43es
dc.publication.issue4es
dc.publication.initialPage937es
dc.publication.endPage939es

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