Article
Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes
Author/s | Hernández Allés, Santiago
Benedí, Vicente J. Martínez Martínez, Luis Pascual Hernández, Álvaro Aguilar, Alicia Tomás, Juan M. Albertí, Sebastián |
Department | Universidad de Sevilla. Departamento de Microbiología |
Publication Date | 1999-01-01 |
Deposit Date | 2017-09-28 |
Published in |
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Abstract | We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to ... We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to cefoxitin in Klebsiella pneumoniae. This mechanism also operates in vivo: of 13 porin-deficient cefoxitin-resistant clinical isolates of K. pneumoniae, 4 presented ISs in their ompK36 gene. |
Citation | Hernández Allés, S., Benedí, V.J., Martínez Martínez, L., Pascual Hernández, Á., Aguilar, A., Tomás, J.M. y Albertí, S. (1999). Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes. Antimicrobial Agents and Chemotherapy, 43 (4), 937-939. |
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