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Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia

 

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Opened Access Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia
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Author: Macías, David
Fernández‐Agüera, Mary Carmen
Bonilla Henao, Victoria
López Barneo, José
Department: Instituto de Biomedicina de Sevilla (IBIS)
Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica
Date: 2014-01
Document type: Article
Abstract: Mutations of the von Hippel–Lindau (VHL) gene are associated with pheochromocytomas and paragangliomas, but the role of VHL in sympathoadrenal homeostasis is unknown. We generated mice lacking Vhl in catecholaminergic cells. They exhibited atrophy o...
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URI: http://hdl.handle.net/11441/64426

DOI: 10.15252/emmm.201404153

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