idUS - Author profile: Macías, David

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Name	Macías, David
Department	Fisiología Médica y Biofísica
Knowledge area	Fisiología
Professional category	Profesor Permanente Laboral - Mod. PCD
E-mail	Request

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10
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694
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Publications
Article Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality Mora Romero, Bella; Capelo Carrasco, Nicolás; Pérez Moreno, Juan José; Álvarez Vergara, María Isabel; Trujillo Estrada, Laura Isabel; Romero Molina, Carmen; Martínez Márquez, Emilio; Morano Catalan, Noelia; Vizuete Chacón, María Luisa; López Barneo, José; Nieto González, José Luis; García-Junco Clemente, Pablo; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia; Macías, David; Rosales Nieves, Alicia E.; Pascual Bravo, Alberto (Nature, 2024) Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders and are traditionally related ...
Article An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence Baker, Andrew G.; Hartono, Muhamad; Ou, Hui-Ling; Popov, Andrea Bistrovic; Brown, Emma L.; Joseph, James; Golinska, Monika; Gonzalez-Gualda, Estela; Macías, David; Fruk, Ljiljana (Wiley, 2024) Abstract: There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer ...
Article Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors Lambden, Simon; Cowburn, Andrew S.; Macías, David; Garrud, Tessa A. C.; Krause, Bernardo J.; Giussani, Dino A.; Summers, Charlotte; Johnson, Randall S. (SpringerOpen, 2021) Background The vascular endothelium has important endocrine and paracrine roles, particularly in the regulation of vascular ...
Article Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension Macías, David; Moore, Stephen; Crosby, Alexi; Southwood, Mark; Du, Xinlin; Tan, Huiling; Cowburn, Andrew S. (European Respiratory Society, 2021) Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart ...
Article Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity González-Gualda, E.; Páez-Ribes, M.; Lozano-Torres, B.; Macías, David; Wilson III, J. R.; González-López, C.; Ou, H. L. (Wiley Open Access, 2020) Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ...
Article 2-hydroxyglutarate metabolism is altered in an in vivo model of LPS induced endotoxemia Fitzpatrick, S. F.; Lambden, S.; Macías, David; Puthucheary, Z.; Pietsch, S.; Mendil, L. (Frontiers Media, 2020) The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the ...
Article HIF-2a is essential for carotid body development and function Macías, David; Cowburn, Andrew S.; Torres Torrelo, Hortensia; Ortega Sáenz, Patricia; López Barneo, José; Johnson, Randall S (eLife Sciences Publications, 2018) Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations ...
Article Carotid body oxygen sensing and adaptation to hipoxia López Barneo, José; Macías, David; Platero-Luengo, Aida; Ortega Sáenz, Patricia; Pardal Redondo, Ricardo (Springer, 2015) The carotid body (CB) is the principal arterial chemoreceptor that mediates the hyperventilatory response to hypoxia. Our ...
Article Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia Macías, David; Fernández‐Agüera Rodríguez, Mari Carmen; Bonilla Henao, Victoria; López Barneo, José (Wiley, 2014) Mutations of the von Hippel–Lindau (VHL) gene are associated with pheochromocytomas and paragangliomas, but the role of ...
Article Implanted neural progenitor cells regulate glial reaction to brain injury and establish gap junctions with host glial cells Talaverón Aguilocho, Rocío; Rodríguez Matarredona, Esperanza; Rodríguez de la Cruz, Rosa María; Macías, David; Gálvez, Victoria; Pastor Loro, Ángel Manuel (Wiley-Blackwell, 2014) Transplantation of neural stem/progenitor cells (NPCs) in the lesioned brain is able to restore morphological and physiological ...