NameMacías, David
DepartmentFisiología Médica y Biofísica
Knowledge areaFisiología
Professional categoryProfesor Permanente Laboral - Mod. PCD
E-mailRequest
           
  • No. publications

    10

  • No. visits

    694

  • No. downloads

    497


 

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Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality

Mora Romero, Bella; Capelo Carrasco, Nicolás; Pérez Moreno, Juan José; Álvarez Vergara, María Isabel; Trujillo Estrada, Laura Isabel; Romero Molina, Carmen; Martínez Márquez, Emilio; Morano Catalan, Noelia; Vizuete Chacón, María Luisa; López Barneo, José; Nieto González, José Luis; García-Junco Clemente, Pablo; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia; Macías, David; Rosales Nieves, Alicia E.; Pascual Bravo, Alberto (Nature, 2024)
Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders and are traditionally related ...
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An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence

Baker, Andrew G.; Hartono, Muhamad; Ou, Hui-Ling; Popov, Andrea Bistrovic; Brown, Emma L.; Joseph, James; Golinska, Monika; Gonzalez-Gualda, Estela; Macías, David; Fruk, Ljiljana (Wiley, 2024)
Abstract: There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer ...
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Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors

Lambden, Simon; Cowburn, Andrew S.; Macías, David; Garrud, Tessa A. C.; Krause, Bernardo J.; Giussani, Dino A.; Summers, Charlotte; Johnson, Randall S. (SpringerOpen, 2021)
Background The vascular endothelium has important endocrine and paracrine roles, particularly in the regulation of vascular ...
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Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension

Macías, David; Moore, Stephen; Crosby, Alexi; Southwood, Mark; Du, Xinlin; Tan, Huiling; Cowburn, Andrew S. (European Respiratory Society, 2021)
Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart ...
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Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

González-Gualda, E.; Páez-Ribes, M.; Lozano-Torres, B.; Macías, David; Wilson III, J. R.; González-López, C.; Ou, H. L. (Wiley Open Access, 2020)
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ...
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2-hydroxyglutarate metabolism is altered in an in vivo model of LPS induced endotoxemia

Fitzpatrick, S. F.; Lambden, S.; Macías, David; Puthucheary, Z.; Pietsch, S.; Mendil, L. (Frontiers Media, 2020)
The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the ...
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HIF-2a is essential for carotid body development and function

Macías, David; Cowburn, Andrew S.; Torres Torrelo, Hortensia; Ortega Sáenz, Patricia; López Barneo, José; Johnson, Randall S (eLife Sciences Publications, 2018)
Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations ...
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Carotid body oxygen sensing and adaptation to hipoxia

López Barneo, José; Macías, David; Platero-Luengo, Aida; Ortega Sáenz, Patricia; Pardal Redondo, Ricardo (Springer, 2015)
The carotid body (CB) is the principal arterial chemoreceptor that mediates the hyperventilatory response to hypoxia. Our ...
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Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia

Macías, David; Fernández‐Agüera Rodríguez, Mari Carmen; Bonilla Henao, Victoria; López Barneo, José (Wiley, 2014)
Mutations of the von Hippel–Lindau (VHL) gene are associated with pheochromocytomas and paragangliomas, but the role of ...
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Implanted neural progenitor cells regulate glial reaction to brain injury and establish gap junctions with host glial cells

Talaverón Aguilocho, Rocío; Rodríguez Matarredona, Esperanza; Rodríguez de la Cruz, Rosa María; Macías, David; Gálvez, Victoria; Pastor Loro, Ángel Manuel (Wiley-Blackwell, 2014)
Transplantation of neural stem/progenitor cells (NPCs) in the lesioned brain is able to restore morphological and physiological ...