• Article
  

  Impact of FLT3–ITD mutation status and its ratio in a cohort of 2901 patients undergoing upfront intensive chemotherapy: a PETHEMA registry study 

  Ayala, Rosa; Carreño-Tarragona, Gonzalo; Barragán, Eva; Boluda, Blanca; Larráyoz, María J.; Chillón, María Carmen; Pérez Simón, José Antonio; Montesinos, Pau (MDPI, 2022-11-22)

  FLT3–ITD results in a poor prognosis in terms of overall survival (OS) and relapse-free survival (RFS) in acute myeloid ...

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  Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficiency: EARCO international registry 

  Miravitlles, Marc; Turner, Alice M.; Torres-Durán, María; Tanash, Hanan; Rodríguez-García, Carlota; López-Campos Bodineau, José Luis; Clarenbach, Christian F. (BIOMED CENTRAL LTD, 2023)

  Background Alpha-1 antitrypsin deficiency (AATD) is a rare disease that is associated with an increased risk of ...

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  Emerging pharmacological treatment options for MAFLD 

  Rojas, Ángela; Lara-Romero, Carmen; Muñoz Hernández, Rocío; Gato, Sheila; Ampuero Herrojo, Javier; Romero Gómez, Manuel (2022)

  Metabolic dysfunction–associated fatty liver disease (MAFLD) prevalence and incidence is rising globally. It is associated ...

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  Nanostructured fibrin agarose hydrogel as a novel haemostatic agent 

  Campos-Cuerva, Rafael; Fernández Muñoz, Beatriz; Farfán López, Francisco; Pereira Arenas, Sheila; Santos-González, Mónica; Lopez-Navas, Luis; Alaminos, Miguel; Campos, Antonio; Muntané Relat, Jordi; Cepeda-Franco, Carmen; Gómez Bravo, Miguel Ángel (Wiley, 2019)

  Blood loss remains a major concern during surgery and can increase the morbidity of the intervention. The use of topical ...

• Article
  

  Propuesta de nueva denominación: esteatosis hepática metabólica (EHmet) 

  Romero Gómez, Manuel; Ampuero Herrojo, Javier (Arán Ediciones, S.L., 2021)

  El nombre de una enfermedad no sigue ningún protocolo definido y es habitual la aceptación por parte de la comunidad ...

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  Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity 

  Sánchez Hidalgo, Ana Carmen; Arias-Aragón, Francisco; Romero Barragán, M. Teresa; Martín-Cuevas, Celia; Delgado-García, José M; Martinez-Mir, Amalia; Gómez Scholl, Francisco Manuel (Elsevier, 2021-10-15)

  Presenilins (PS) form the active subunit of the gamma-secretase complex, which mediates the proteolytic clearance of a ...

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  Lupinus angustifolius Protein Hydrolysates Reduce Abdominal Adiposity and Ameliorate Metabolic Associated Fatty Liver Disease (MAFLD) in Western Diet Fed-ApoE−/− Mice 

  Santos-Sánchez, Guillermo; Cruz-Chamorro, Ivan; Álvarez-Ríos, Ana Isabel; Lardone, Patricia Judith; Guerrero Montávez, Juan Miguel; Bejarano Hernando, Ignacio; Carrillo Vico, Antonio (MDPI, 2021-07-29)

  Metabolic-associated fatty liver disease (MAFLD) is the most important cause of liver disease worldwide. It is characterized ...

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  SARAF and EFHB Modulate Store-Operated Ca2+ Entry and Are Required for Cell Proliferation, Migration and Viability in Breast Cancer Cells 

  Jardin, Isaac; Nieto Felipe, Enrique; Alvarado, Sandra; Diez Bello, Raquel; López, Jose J.; Smani Hajami, Tarik; Rosado, Juan Antonio (MDPI, 2021)

  Breast cancer is among the most common malignancies in women. From the molecular point of view, breast cancer can be ...

• Article
  

  Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project 

  Santos García, Diego; Blázquez-Estrada, Marta; Calopa, Matilde; Escamilla-Sevilla, Francisco; Freire, Eric; Mir Rivera, Pablo; Luquín, María-Rosario (MDPI, 2021-07-31)

  Abstract: Parkinson’s disease (PD) is a chronic progressive and irreversible disease and the second most common ...

• Article
  

  Esclerosis múltiple y trastornos asociados al consumo de alcohol: mortalidad atribuible, prolongación de estancias y exceso de costes hospitalarios 

  Gili Miner, Miguel; López Méndez, Julio; Vilches Arenas, Ángel; Ramírez Ramírez, G.; Franco Fernández, D.; Sala-Turrens, J.; Béjar Prado, Luis María (Sociedad Española de Neurología, 2016-10-22)

  Introducción: El objetivo de este estudio es el análisis del impacto de los trastornos asociados al consumo de alcohol(TCA) ...

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  Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia 

  Romero-Ruiz, Antonio; Bautista, Lucía; Navarro, Virginia; Heras Garvín, Antonio; Castellano Orozco, Antonio Gonzalo; López Barneo, José; Pascual, Alberto (American Society for Biochemistry and Molecular Biology, 2012-02-03)

  Early adaptive responses to hypoxia are essential for cell survival, but their nature and underlying mechanisms are poorly ...

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  Immunomodulatory and Antioxidant Properties of Wheat Gluten Protein Hydrolysates in Human Peripheral Blood Mononuclear Cells 

  Cruz-Chamorro, Ivan; Álvarez-Sánchez, Nuria; Santos-Sánchez, Guillermo; Lardone, Patricia Judith; Bejarano, Ignacio; Guerrero, Juan Miguel; Carrillo Vico, Antonio (MDPI, 2020-06-04)

  Peptides from several plant food proteins not only maintain the nutritional values of the original protein and decrease ...

• Article
  

  Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients 

  Álvarez-Sánchez, Nuria; Cruz-Chamorro, Ivan; Díaz Sánchez, María; Lardone, Patricia Judith; Guerrero Montávez, Juan Miguel; Carrillo Vico, Antonio (Nature Research, 2019-02-19)

  CD39, an ectonucleotidase that hydrolyses pro-infammatory ATP, is a marker of highly active and suppressive T regulatory ...

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  Glucose sensing by carotid body glomus cells: potential implications in disease 

  Gao Chen, Lin; Ortega Sáenz, Patricia; García Fernández, María; González Rodríguez, Patricia; Caballero Eraso, Candela; López Barneo, José (Frontiers Media, 2014-10-15)

  The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. ...

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  A variant in the MICA gene is associated with liver fbrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms 

  El Sharkawy, Rasha; Bayoumi, Ali; Metwally, Mayada; Mangia, Alessandra; Ryberg, Thomas; Romero Gómez, Manuel; Eslam, Mohammed (Nature Research, 2019-02-05)

  Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 ...

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  Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study 

  Maurel, Joan; López-Pousa, Antonio; Calabuig, Silvia; Bagué, Silvia; García del Muro, Xavier; Sanjuan, Xavier; Álava Casado, Enrique de (BMC, 2016-06-29)

  Background: Most GISTs have mutations in KIT or PDGFRA. Patients with advanced GIST with KIT exon 9, PDGFRA mutation or ...

• Article
  

  Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival 

  D'Anglemont De Tassigny, Xavier; Sirerol-Piquer, M Salomé; Gómez-Pinedo, Ulises; Pardal Redondo, Ricardo; Bonilla, Sonia; Capilla González, Vivian; López Barneo, José (Dove Medical Press Ltd., 2015)

  Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive ...

• Article
  

  Neurocognitive Function in Acromegaly after Surgical Resection of GH-Secreting Adenoma versus Naïve Acromegaly 

  Martín Rodríguez, Juan Francisco; Madrazo Atutxa, Ainara; Venegas Moreno, Eva; Benito López, Pedro; Gálvez, María Ángeles; Cano, David A.; Soto Moreno, Alfonso Manuel; Leal Cerro, Alfonso (Elsevier, 2013-04-04)

  Patients with active untreated acromegaly show mild to moderate neurocognitive disorders that are associated to chronic ...

• Article
  

  Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer 

  Rodríguez Hernández, María A.; Cruz Ojeda, Patricia de la; López-Grueso, María José; Navarro Villarán, Elena; Requejo-Aguilar, Raquel; Castejón Vega, Beatriz; Muntané Relat, Jordi (Elsevier, 2020-03-16)

  Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals, evasion of apoptosis,cellular ...

• Article
  

  Changing Trends in the Epidemiology and Risk Factors of Pneumocystis Pneumonia in Spain 

  Pereira-Díaz, Estefanía; Moreno-Verdejo, Fidel; Horra Padilla, Carmen de la; Guerrero, José A.; Calderón Sandubete, Enrique José; Medrano Ortega, Francisco Javier (2019-10-04)

  Objective: The information about the epidemiology of Pneumocystis pneumonia (PcP) in Europe is scarce, and in Spain there ...

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