Recent Submissions

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    Research highlights from the 2018 European Respiratory Society International Congress: Airway disease  [Article]

    Schleich, Florence; Bikov, Andras; Mathioudakis, Alexander G.; McDonnell, Melissa; Andersson, Cecilia; Bonini, Matteo; Uller, Lena; Idzko, Marco; Singh, Dave; López Campos, José Luis (European Respiratory Society, 2010)
    The annual European Respiratory Society (ERS) International Congress (held in Paris in 2018) was once again a platform for discussion of the highest-quality scientific research, cutting-edge techniques and innovative new ...
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    Epigenetic Mechanisms in Hirschsprung Disease  [Article]

    Torroglosa, Ana; Villalba Benito, Leticia; Luzón-Toro, Berta; Fernández García, Raquel María; Antiñolo Gil, Guillermo; Borrego López, Salud (MDPI, 2019-06-26)
    Hirschsprung disease (HSCR, OMIM 142623) is due to a failure of enteric precursor cells derived from neural crest (EPCs) to proliferate, migrate, survive or differentiate during Enteric Nervous System (ENS) formation. This ...
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    Redox-dependent and redox-independent functions of Caenorhabditis elegans thioredoxin 1  [Article]

    Sanzo-Machuca, Ángela; Monje Moreno, José Manuel; Casado-Navarro, Rafael; Karakuzu, Ozgur; Guerrero Gómez, David; Fierro-González, Juan Carlos; Swoboda, Peter; Muñoz, Manuel J.; Miranda Vizuete, Antonio (Elsevier, 2019-06)
    Thioredoxins (TRX) are traditionally considered as enzymes catalyzing redox reactions. However, redox-independent functions of thioredoxins have been described in different organisms, although the underlying molecular ...
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    FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress  [Article]

    Martínez Macías, María Isabel; Green, Ryan L.; Gómez Herreros, Fernando; Naumann, Marcel; Hermann, Andreas; Hafezparast, Majid; Caldecott, Keith W.; Moore, Duncan A. Q.; Damme, Philip Van (Rockefeller University Press, 2019-02-26)
    FUS (fused in sarcoma) plays a key role in several steps of RNA metabolism, and dominant mutations in this protein are associated with neurodegenerative diseases. Here, we show that FUS is a component of the cellular ...
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    Late-onset thymidine kinase 2 deficiency: a review of 18 cases  [Article]

    Domínguez González, Cristina; Hernández Laín, Aurelio; Rivas, Eloy; Hernández Voth, Ana R.; Sayas Catalán, Javier; Fernández Torrón, Roberto; Fuiza Luces, Carmen; García García, Jorge M.; Caballero Eraso, Candelaria; Paradas, Carmen (Springer Nature, 2019-05-06)
    BACKGROUND: TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 gene are responsible for the 'myopathic form' of ...
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    FGFR1 Cooperates with EGFR in Lung Cancer Oncogenesis, and Their Combined Inhibition Shows Improved Efficacy  [Article]

    Quintanal Villalonga, Álvaro Diego; Molina Pinelo, Sonia; Cirauqui, Cristina; Ojeda Márquez, Laura; Marrugal, Ángela; Suárez, Rocío; Conde, Esther; Ponce Aix, Santiago; Enguita, Ana Belén; Ferrer, Irene; Paz Ares, Luis; Carnero Moya, Amancio (Elsevier, 2019-04)
    Introduction: There is substantial evidence for the onco- genic effects of fi broblast growth factor receptor 1 (FGFR1) in many types of cancer, including lung cancer, but the role of this receptor has not been ...
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    E-cadherin expression is associated with somatostatin analogue response in acromegaly  [Article]

    Venegas Moreno, Eva; Flores Martínez, Álvaro; Dios, Elena; Vázquez Borrego, Mari C.; Ibáñez Costa, Alejandro; Madrazo Atutxa, Ainara; Japón Rodríguez, Miguel Ángel; Castaño, Justo P.; Luque, Raúl M.; Cano, David A.; Soto Moreno, Alfonso Manuel (Wiley-Blackwell, 2019)
    Acromegaly is a rare disease resulting from hypersecretion of growth hormone (GH) and insulin‐like growth factor 1 (IGF1) typically caused by pituitary adenomas, which is associated with increased mortality and morbidity. ...
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    Immunometabolism is a key factor for the persistent spontaneous elite control of HIV-1 infection  [Article]

    Tarancon Diez, Laura; Rodríguez-Gallego, Laura; Rull, Anna; Peraire, Joaquim; Viladés, Consuelo; Portilla, Irene; Jiménez León, María Reyes; Alba, Verónica; Herrero, Pol; Leal Noval, Manuel; Ruiz Mateos Carmona, Ezequiel; Vidal, Francesc (Elsevier, 2019-03)
    Approximately 25% of elite controllers (ECs) lose their virological control by mechanisms that are only partially known. Recently, immunovirological and proteomic factors have been associated to the loss of spontaneous ...
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    Visualization of coronary arteries in paediatric patients using whole-heart coronary magnetic resonance angiography: comparison of image-navigation and the standard approach for respiratory motion compensation  [Article]

    Velasco Forte, Mari Nieves; Valverde, Israel; Prabhu, Nanda; Correia, Teresa; Narayan, Srinivas Ananth; Bell, Aaron; Mathur, Sujeev; Razavi, Reza; Hussain, Tarique; Pushparajah, Kuberan; Henningsson, Markus (Springer Nature, 2019-02)
    Aims: To investigate the use of respiratory motion compensation using image-based navigation (iNAV) with constant respiratory efficiency using single end-expiratory thresholding (CRUISE) for coronary magnetic resonance ...
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    Altered myogenesis and premature senescence underlie human TRIM32-related myopathy  [Article]

    Servián Morilla, Emilia; Cabrera Serrano, Macarena; Carvajal, A.; Lamont, P.J.; Pelayo Negro, A. L.; Ravenscroft, G.; Junckerstorff, R.; Dyke, J.M; Fletcher, S.; Adams, A. M.; Fernández García, M. A.; Nieto González, José Luis; Laing, N. G.; Rivas, Eloy; Mavillard Saborido, Fabiola; Paradas, Carmen (Springer Nature, 2019-03-01)
    TRIM32 is a E3 ubiquitin -ligase containing RING, B-box, coiled-coil and six C-terminal NHL domains. Mutations involving NHL and coiled-coil domains result in a pure myopathy (LGMD2H/STM) while the only described mutation ...
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    The impact of initial antibiotic treatment failure: Real-world insights in patients with complicated, health care-associated intra-abdominal infection  [Article]

    Peeters, Pascale; Ryan, Kellie; Karve, Sudeep; Potter, Danielle; Baelen, Elisa; Rojas-Farreras, Sonia; Rodríguez-Baño, Jesús (Dove, 2019-01-31)
    Purpose: The RECOMMEND study (NCT02364284; D4280R00005) assessed the clinical management patterns and treatment outcomes associated with initial antibiotic therapy (IAT; antibiotics administered ≤48 hours post-initiation ...
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    Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis  [Article]

    Martínez-Florensa, Mario; Consuegra-Fernández, Marta; Aranda, Fernando; Armiger-Borràs, Noelia; Di Scala, Marianna; Carrasco, Esther; Pachón Díaz, Jerónimo; Vila, Jordi; González-Aseguinolaza, Gloria; Lozano, Francisco (American Society for Microbiology, 2017-11)
    Sepsis still constitutes an unmet clinical need, which could benefit from novel adjunctive strategies to conventional antibiotic therapy. The soluble form of the scavenger-like human CD6 lymphocyte receptor (shCD6) binds ...
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    Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology  [Article]

    Romero Molina, Carmen; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Jiménez Muñoz, Sebastián; Fernández Valenzuela, Juan José; Sánchez Mico, María; Muñoz Castro, Clara; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Frontiers Media Research Foundation, 2018-11-14)
    Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology ...
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    In vitro Activity of Pentamidine Alone and in Combination With Aminoglycosides, Tigecycline, Rifampicin, and Doripenem Against Clinical Strains of Carbapenemase-Producing and/or Colistin-Resistant Enterobacteriaceae  [Article]

    Cebrero Cangueiro, Tania; Álvarez Marín, Rocío; Labrador Herrera, Gema; Smani, Younes; Cordero Matía, María Elisa (Frontiers Media SA, 2018-10-18)
    Enterobacteriaceae cause different types of community- and hospital-acquired infections. Moreover, the spread of multidrug-resistant Enterobacteriaceae is a public health problem and the World Health Organization pointed ...
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    Association between sleep-disordered breathing and breast cancer aggressiveness  [Article]

    Campos-Rodríguez, Francisco; Cruz-Medina, Antonio; Selma, María José; Rodríguez-de-la-Borbolla-Artacho, María; Sanchez-Vega, Adrian; Ripoll-Orts, Francisco; Almeida González, Carmen V.; Martinez-Garcia, Miguel Angel (Public Library of Science, 2018-11-21)
    Background Sleep-disordered breathing (SDB) has been associated with cancer aggressiveness, but studies focused on specific tumors are lacking. In this pilot study we investigated whether SDB is associated with breast ...
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    Intestinal colonization due to Escherichia coli ST131: Risk factors and prevalence  [Article]

    Morales Barroso, Isabel; López Cerero, Lorena; Navarro, María Dolores; Gutiérrez Gutiérrez, Belén; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Biomed Central, 2018-11-15)
    Background Escherichia coli sequence type 131 (ST131) is a successful clonal group that has dramatically spread during the last decades and is considered an important driver for the rapid increase of quinolone resistance ...
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    Substantia nigra dopaminergic neurons and striatalinterneurons are engaged in three parallel but interdependentpostnatal neurotrophic circuits  [Article]

    Ortega de San Luís, Clara; Sánchez García, Manuel A.; Nieto González, José Luis; García-Junco Clemente, Pablo; Montero Sánchez, Adoración; Fernández-Chacón, Rafael; Pascual, Alberto (Anatomical Society of Great Britain and Ireland, 2018-06-11)
    The striatum integrates motor behavior using a well‐defined microcircuit whose individual components are independently affected in several neurological diseases. The glial cell line‐derived neurotrophic factor (GDNF), ...
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    Evidence of the Red-Queen Hypothesis from Accelerated Rates of Evolution of Genes Involved in Biotic Interactions in Pneumocystis  [Article]

    Delaye, Luis; Ruiz-Ruiz, Susana; Calderon, Enrique; Tarazona, Sonia; Conesa, Ana; Moya, Andrés (Oxford University Press, 2018-06-11)
    Pneumocystis species are ascomycete fungi adapted to live inside the lungs of mammals. These ascomycetes show extensive stenoxenism, meaning that each species of Pneumocystis infects a single species of host. Here, we study ...
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    Identification of oxidative stress related proteins as biomarkers for lung cancer and chronic obstructive pulmonary disease in bronchoalveolar lavage  [Article]

    Pastor, María Dolores; Nogal, Ana; Molina-Pinelo, Sonia; Meléndez, Ricardo; Romero-Romero, Beatriz; Mediano, Maria Dolores; López-Campos, José L.; García-Carbonero, Rocío; Sanchez-Gastaldo, Amparo; Carnero Moya, Amancio; Paz-Ares Rodríguez, Luis (MDPI AC, 2013-02-06)
    Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) commonly coexist in smokers, and the presence of COPD increases the risk of developing LC. Cigarette smoke causes oxidative stress and an inflammatory ...
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    Can clays in livestock feed promote antibiotic resistance and virulence in pathogenic bacteria?  [Article]

    Rodríguez-Rojas, Alexandro; Rodríguez-Beltrán, Jerónimo; Valverde, José R; Blázquez, Jesús (MDPI AG, 2015-07-16)
    The use of antibiotics in animal husbandry has long been associated with the appearance of antibiotic resistance and virulence factor determinants. Nonetheless, the number of cases of human infection involving resistant ...

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