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Mostrando ítems 1-10 de 11
Artículo
Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan- Neuronal Activation in the Female Mouse.
(2016-10-14)
Gender difference in Parkinson’s disease (PD) suggests that female sex steroids may promote dopaminergic neuron survival and protect them from degeneration. The glial cell line-derived neurotrophic factor (GDNF) is believed ...
Artículo
Embracing monogenic Parkinson's disease: the MJFF global genetic PD cohort
(Wiley, 2023)
ABSTRACT: Background: As gene-targeted therapies are increasingly being developed for Parkinson’s disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a ...
Artículo
Effects of Rho Kinase Inhibitors on Grafts of Dopaminergic Cell Precursors in a Rat Model of Parkinson's Disease.
(Wiley Online, 2016-04-13)
In models of Parkinson’s disease (PD), Rho kinase (ROCK) inhibitors have antiapoptotic and axonstabilizing effects on damaged neurons, decrease the neuroinflammatory response, and protect against dopaminergic neuron death ...
Artículo
Sex differences in motor and non-motor symptoms among Spanish patients with Parkinson’s disease
(MDPI, 2023)
Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the ...
Artículo
The social impact of Parkinson’s disease in Spain: Report by the Spanish Foundation for the Brain
(Elsevier, 2016)
Introduction: Understanding the social and economic impact of Parkinson’s disease is essential for resource planning and raising social awareness. Development: Researchers reviewed the data published to date on epidemiology, ...
Artículo
Substantia nigra dopaminergic neurons and striatalinterneurons are engaged in three parallel but interdependentpostnatal neurotrophic circuits
(Anatomical Society of Great Britain and Ireland, 2018-06-11)
The striatum integrates motor behavior using a well‐defined microcircuit whose individual components are independently affected in several neurological diseases. The glial cell line‐derived neurotrophic factor (GDNF), ...
Artículo
GBA Variants Influence Motor and Non-Motor Features of Parkinson’s Disease.
(Public Library Of Science, 2016-12-28)
The presence of mutations in glucocerebrosidase (GBA) gene is a known factor increasing the risk of developing Parkinson’s disease (PD). Mutations carriers have earlier disease onset and are more likely to develop ...
Artículo
Tremor stability index: a new tool for differential diagnosis in tremor syndromes
(Oxford University Press, 2017)
Misdiagnosis among tremor syndromes is common, and can impact on both clinical care and research. To date no validated neurophysiological technique is available that has proven to have good classification performance, and ...
Artículo
Machine learning models for the differential diagnosis of vascular parkinsonism and Parkinson's disease using [(123)I]FP-CIT SPECT
(Springer, 2015)
Purpose: The study’s objective was to develop diagnostic predictive models using data from two commonly used [(123)I]FP-CIT SPECT assessment methods: region-of-interest (ROI) analysis and whole-brain voxel-based analysis. ...
Artículo
Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project
(MDPI, 2021-07-31)
Abstract: Parkinson’s disease (PD) is a chronic progressive and irreversible disease and the second most common neurodegenerative disease worldwide. In Spain, it affects around 120.000–150.000 individuals, and its ...