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Chaperoned amyloid proteins for immune manipulation: a-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype

Opened Access Chaperoned amyloid proteins for immune manipulation: a-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype

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Autor: Labrador Garrido, Adahir
Cejudo Guillén, Marta
Klippstein Martin, Rebecca
Genst, Erwin J De
Tomas Gallardo, Laura
Leal, María M.
Pozo Pérez, David
Departamento: Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología
Fecha: 2014
Publicado en: Immunity, Inflammation and Disease, 2 (4), 226-238.
Tipo de documento: Artículo
Resumen: α-Synuclein (αSyn) is a 140-residue amyloid-forming protein whose aggregation is linked to Parkinson's disease (PD). It has also been found to play a critical role in the immune imbalance that accompanies disease progression, a characteristic that has prompted the search for an effective αSyn-based immunotherapy. In this study, we have simultaneously exploited two important features of certain heat-shock proteins (HSPs): their classical “chaperone” activities and their recently discovered and diverse “immunoactive” properties. In particular, we have explored the immune response elicited by immunization of C57BL/6 mice with an αSyn/Hsp70 protein combination in the absence of added adjuvant. Our results show differential effects for mice immunized with the αSyn/Hsp70 complex, including a restrained αSyn-specific (IgM and IgG) humoral response as well as minimized alterations in the Treg (CD4+CD25+Foxp3+) and Teff (CD4+Foxp3−) cell populations, as opposed to significant changes in mice i...
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Cita: Labrador Garrido, A., Cejudo Guillén, M., Klippstein Martin, R., Genst, E.J.D., Tomas Gallardo, L., Leal, M.M. y Pozo Pérez, D. (2014). Chaperoned amyloid proteins for immune manipulation: a-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype. Immunity, Inflammation and Disease, 2 (4), 226-238.
Tamaño: 990.1Kb
Formato: PDF

URI: http://hdl.handle.net/11441/64290

DOI: 10.1002/iid3.39

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