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Regulation of replication fork advance and stability by nucleosome assembly

Opened Access Regulation of replication fork advance and stability by nucleosome assembly

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Autor: Prado, Félix
Maya, Douglas
Fecha: 2017
Publicado en: Genes, 8 (2), 49-.
Tipo de documento: Artículo
Resumen: he advance of replication forks to duplicate chromosomes in dividing cells requires the disassembly of nucleosomes ahead of the fork and the rapid assembly of parental and de novo histones at the newly synthesized strands behind the fork. Replication-coupled chromatin assembly provides a unique opportunity to regulate fork advance and stability. Through post-translational histone modifications and tightly regulated physical and genetic interactions between chromatin assembly factors and replisome components, chromatin assembly: (1) controls the rate of DNA synthesis and adjusts it to histone availability; (2) provides a mechanism to protect the integrity of the advancing fork; and (3) regulates the mechanisms of DNA damage tolerance in response to replication-blocking lesions. Uncoupling DNA synthesis from nucleosome assembly has deleterious effects on genome integrity and cell cycle progression and is linked to genetic diseases, cancer, and aging.
Cita: Prado, F. y Maya, D. (2017). Regulation of replication fork advance and stability by nucleosome assembly. Genes, 8 (2), 49-.
Tamaño: 1.052Mb
Formato: PDF

URI: http://hdl.handle.net/11441/64268

DOI: 10.3390/genes8020049

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