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Learning and memory disabilities in IUGR babies: Functional and molecular analysis in a rat model

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Autor: Camprubí Camprubí, Marta
Balada Caballé, Rafel
Ortega Cano, Juan A.
Ortega de la Torre, María de los Ángeles
Duran Fernández-Feijoo, Cristina
Figueras Aloy, Josep
Girabent Farrés, Montserrat
Krauel, Xavier
Alcántara, Soledad
Fecha: 2017
Publicado en: Brain and Behavior, 7 (3), e00631-.
Tipo de documento: Artículo
Resumen: Introduction: Intrauterine growth restriction (IUGR) is the failure of the fetus to achieve its inherent growth potential, and it has frequently been associated with neurodevelopmental problems in childhood. Neurological disorders are mostly associated with IUGR babies with an abnormally high cephalization index (CI) and a brain sparing effect. However, a similar correlation has never been demonstrated in an animal model. The aim of this study was to determine the correlations between CI, functional deficits in learning and memory and alterations in synaptic proteins in a rat model of IUGR. Methods: Utero-placental insufficiency was induced by meso-ovarian vessel cauterization (CMO) in pregnant rats at embryonic day 17 (E17). Learning performance in an aquatic learning test was evaluated 25 days after birth and during 10 days. Some synaptic proteins were analyzed (PSD95, Synaptophysin) by Western blot and immunohistochemistry. Results: Placental insufficiency in CMO pups was associate...
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Cita: Camprubí Camprubí, M., Balada Caballé, R., Ortega Cano, J.A., Ortega de la Torre, M.d.l.Á., Duran Fernández-Feijoo, C., Figueras Aloy, J.,...,Alcántara, S. (2017). Learning and memory disabilities in IUGR babies: Functional and molecular analysis in a rat model. Brain and Behavior, 7 (3), e00631-.
Tamaño: 1.296Mb
Formato: PDF

URI: http://hdl.handle.net/11441/64267

DOI: 10.1002/brb3.631

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