Artículo
Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c
Autor/es | González Arzola, Katiuska
Díaz Quintana, Antonio Jesús Rivero Rodríguez, Francisco Velázquez Campoy, Adrián Rosa Acosta, Miguel Ángel de la Díaz Moreno, Irene |
Fecha de publicación | 2017 |
Fecha de depósito | 2017-08-30 |
Publicado en |
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Resumen | Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative DNA damage. Most studies on the DNA repair process have focused on yeast and mammals, in which histone chaperone-mediated nucleosome ... Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative DNA damage. Most studies on the DNA repair process have focused on yeast and mammals, in which histone chaperone-mediated nucleosome disassembly/reassembly is essential for DNA to be accessible to repair machinery. However, little is known about the specific role and modulation of histone chaperones in the context of DNA damage in plants. Here, the histone chaperone NRP1, which is closely related to human SET/TAF-Iβ, was found to exhibit nucleosome assembly activity in vitro and to accumulate in the chromatin of Arabidopsis thaliana after DNA breaks. In addition, this work establishes that NRP1 binds to cytochrome c, thereby preventing the former from binding to histones. Since NRP1 interacts with cytochrome c at its earmuff domain, that is, its histone-binding domain, cytochrome c thus competes with core histones and hampers the activity of NRP1 as a histone chaperone. Altogether, the results obtained indicate that the underlying molecular mechanisms in nucleosome disassembly/reassembly are highly conserved throughout evolution, as inferred from the similar inhibition of plant NRP1 and human SET/TAF-Iβ by cytochrome c during DNA damage response. |
Agencias financiadoras | Junta de Andalucía Ministerio de Economía y Competitividad (MINECO). España |
Identificador del proyecto | info:eu-repo/grantAgreement/MINECO/BFU2015-71017/BMC
info:eu-repo/grantAgreement/MINECO/BFU2013-47064 BIO198 |
Cita | González Arzola, K., Díaz Quintana, A., Rivero Rodríguez, F., Velázquez Campoy, A., Rosa, M.A.d.l. y Díaz Moreno, I. (2017). Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c. Nucleic Acids Research, 45 (4), 2150-2165. |
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Histone chaperone activity.pdf | 5.752Mb | [PDF] | Ver/ | |