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Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate

Opened Access Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate

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Autor: Ortega, Ángeles
Berná, Genoveva
Rojas, Anabel
Martín, Franz
Soria, Bernat
Fecha: 2017
Publicado en: International Journal of Molecular Sciences, 18 (6), 1-40.
Tipo de documento: Artículo
Resumen: Consistent evidence from both experimental and human studies indicates that Type 2 diabetes mellitus (T2DM) is a complex disease resulting from the interaction of genetic, epigenetic, environmental, and lifestyle factors. Nutrients and dietary patterns are important environmental factors to consider in the prevention, development and treatment of this disease. Nutritional genomics focuses on the interaction between bioactive food components and the genome and includes studies of nutrigenetics, nutrigenomics and epigenetic modifications caused by nutrients. There is evidence supporting the existence of nutrient-gene and T2DM interactions coming from animal studies and family-based intervention studies. Moreover, many case-control, cohort, cross-sectional cohort studies and clinical trials have identified relationships between individual genetic load, diet and T2DM. Some of these studies were on a large scale. In addition, studies with animal models and human observational studies, in d...
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Cita: Ortega, Á., Berná, G., Rojas, A., Martín, F. y Soria, B. (2017). Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate. International Journal of Molecular Sciences, 18 (6), 1-40.
Tamaño: 687.7Kb
Formato: PDF

URI: http://hdl.handle.net/11441/63842

DOI: 10.3390/ijms18061188

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