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Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis

Opened Access Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis

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Autor: Guevara Miranda, David Ladrón de
Millón, Carmelo
Rosell Valle, Cristina
Pérez Fernández, Mercedes
Missiroli, Michele
Fecha: 2017
Publicado en: Disease Models and Mechanisms, 10 (3), 323-336.
Tipo de documento: Artículo
Resumen: Cocaine addiction disorder is notably aggravated by concomitant cognitive and emotional pathology that impedes recovery. We studied whether a persistent cognitive/emotional dysregulation in mice withdrawn from cocaine holds a neurobiological correlate within the hippocampus, a limbic region with a key role in anxiety and memory but that has been scarcely investigated in cocaine addiction research. Mice were submitted to a chronic cocaine (20 mg/kg/day for 12 days) or vehicle treatment followed by 44 drug-free days. Some mice were then assessed on a battery of emotional (elevated plus-maze, light/dark box, open field, forced swimming) and cognitive (object and place recognition memory, cocaine-induced conditioned place preference, continuous spontaneous alternation) behavioral tests, while other mice remained in their home cage. Relevant hippocampal features [basal c-Fos activity, GABA+, parvalbumin (PV)+ and neuropeptide Y (NPY)+ interneurons and adult neurogenesis (cell proliferation...
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Cita: Guevara Miranda, D.L.d., Millón, C., Rosell Valle, C., Pérez Fernández, M. y Missiroli, . (2017). Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis. Disease Models and Mechanisms, 10 (3), 323-336.
Tamaño: 11.41Mb
Formato: PDF

URI: http://hdl.handle.net/11441/63786

DOI: 10.1242/dmm.026682

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