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Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal

Opened Access Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal

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Autor: Ayala Gómez, Antonio
Muñoz, Mario F.
Argüelles, Sandro
Departamento: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Fecha: 2014
Publicado en: Oxidative medicine and cellular longevity, (360438), 1-32.
Tipo de documento: Artículo
Resumen: Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs). Over the last four decades, an extensive body of literature regarding lipid peroxidation has shown its important role in cell biology and human health. Since the early 1970s, the total published research articles on the topic of lipid peroxidation was 98 (1970–1974) and has been increasing at almost 135-fold, by up to 13165 in last 4 years (2010–2013). New discoveries about the involvement in cellular physiology and pathology, as well as the control of lipid peroxidation, continue to emerge every day. Given the enormity of this field, this review focuses on biochemical concepts of lipid peroxidation, production, metabolism, and signaling mechanisms of two main omega-6 fatty acids lipid peroxidation products: malondialdehyde (MDA) and, in particular, 4-hydroxy-2-nonenal (4-HNE), summa...
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Cita: Ayala Gómez, A., Muñoz, M.F. y Argüelles, S. (2014). Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxidative medicine and cellular longevity, (360438), 1-32.
Tamaño: 1.735Mb
Formato: PDF

URI: http://hdl.handle.net/11441/41540

DOI: http://dx.doi.org/10.1155/2014/360438

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