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The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions

 

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Opened Access The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions
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Author: Orta Vázquez, Manuel Luis
Höglund, Andreas
Calderón Montaño, José Manuel
Domínguez García, Inmaculada
Burgos Morón, Estefanía
Visnes, Torkild
Pastor Carrillo, Nuria María
Ström, Cecilia
López Lázaro, Miguel
Helleday, Thomas
Department: Universidad de Sevilla. Departamento de Biología Celular
Date: 2014
Published in: Nucleic Acids Research, 42, (14), 9108-9120
Document type: Article
Abstract: Decitabine (5-aza-21-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid Leukemia (AML). Its mechanism of action is thought to involve reactivation of genes implicated in differentiation and transforma...
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Format: PDF

URI: http://hdl.handle.net/11441/41298

DOI: http://dx.doi.org/10.1093/nar/gku638

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