idUS - Perfil del autor: Orta Vázquez, Manuel Luis

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Nombre	Orta Vázquez, Manuel Luis
Departamento	Biología Celular
Área de conocimiento	Biología Celular
Categoría profesional	Profesor Titular de Universidad
Correo electrónico	Solicitar

Nº publicaciones

17
Nº visitas

3479
Nº descargas

11702

Tipología

Orden

Publicaciones
Artículo Metabolic Disturbance of High-Saturated Fatty Acid Diet in Cognitive Preservation Rivas Domínguez, Antonio; Mohamed Mohamed, Himan; Jiménez Palomares, Margarita; García Morales, Victoria; Martínez López, Laura; Orta Vázquez, Manuel Luis; Ramos Rodríguez, Juan José; Bermúdez Pulgarín, Beatriz (Multidisciplinary Digital Publishing Institute (MDPI), 2023) Aging continues to be the main cause of the development of Alzheimer’s, although it has been described that certain chronic ...
Artículo Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors Hajji, Nabil; García Revilla, Juan; Sarmiento Soto, Manuel; Perryman, Richard; Symington, Jake J.; Quarles, Chad C.; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago; Venero Recio, José Luis; Syed, Nelofer (American Society for Clinical Investigation, 2022) New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the ...
Artículo In vitro anticancer activity and mechanism of action of an aziridinyl galactopyranoside Burgos Morón, Estefanía; Pastor Carrillo, Nuria María; Orta Vázquez, Manuel Luis; Jiménez Alonso, Julio José; Palo Nieto, Juan Carlos; Vega Holm, Margarita; Vega Pérez, José Manuel; Iglesias Guerra, Fernando; Mateos Cordero, Santiago; López Lázaro, Miguel; Calderón Montaño, José Manuel (Multidisciplinary Digital Publishing Institute (MDPI), 2022) We recently screened a series of new aziridines β-D-galactopyranoside derivatives for selective anticancer activity and ...
Artículo The Role of DNA Damage Response in Dysbiosis-Induced Colorectal Cancer Rivas Domínguez, Antonio; Pastor Carrillo, Nuria María; Martínez López, Laura; Colón Pérez, Julia; Bermúdez Pulgarín, Beatriz; Orta Vázquez, Manuel Luis (Multidisciplinary Digital Publishing Institute (MDPI), 2021) The high incidence of colorectal cancer (CRC) in developed countries indicates a predominant role of the environment as a ...
Artículo Selective cytotoxic activity and DNA damage by an epoxyalkyl galactopyranoside Burgos Morón, Estefanía; Pastor Carrillo, Nuria María; Orta Vázquez, Manuel Luis; Jiménez Alonso, Julio José; Vega Holm, Margarita; Vega Pérez, José Manuel; Iglesias Guerra, Fernando; Mateos Cordero, Santiago; López Lázaro, Miguel; Calderón Montaño, José Manuel (Wiley, 2018) Several clinically useful anticancer drugs selectively kill cancer cells by inducing DNA damage; the genomic instability ...
Artículo The Cockayne syndrome protein B is involved in the repair of 5-AZA-2′-deoxycytidine-induced DNA lesions Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Pastor Carrillo, Nuria María; Ruiz Castizo, Ángel; Domínguez García, Inmaculada; López Lázaro, Miguel; Mateos Cordero, Santiago; Orta Vázquez, Manuel Luis (Impact Journals, 2018) The Cockayne Syndrome Protein B (CSB) plays an essential role in Transcription-Coupled Nucleotide Excision Repair (TC-NER) ...
Artículo Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination Orta Vázquez, Manuel Luis; Pastor Carrillo, Nuria María; Burgos Morón, Estefanía; Domínguez García, Inmaculada; Calderón Montaño, José Manuel; Huertas Castaño, Carlos; López Lázaro, Miguel; Helleday, Thomas; Mateos Cordero, Santiago (Elsevier, 2017) Zebularine is a second-generation, highly stable hydrophilic inhibitor of DNA methylation with oral bioavailability that ...
Artículo RENEB accident simulation exercise Brzozowska, Beata; Ainsbury, Elizabeth; Baert, Annelot; Beaton Green, Lindsay; Barrios, Leonardo; Barquinero, Joan Francesc; Domínguez García, Inmaculada; Orta Vázquez, Manuel Luis; Wojcik, Andrzej (Taylor & Francis LTD, 2017) Purpose: The RENEB accident exercise was carried out in order to train the RENEB participants in coordinating and managing ...
Artículo Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Orta Vázquez, Manuel Luis; Guillén Mancina, Emilio; Mateos Cordero, Santiago; López Lázaro, Miguel (MDPI AG, 2016) Epidemiological studies have found a positive association between coffee consumption and a lower risk of cardiovascular ...
Trabajo Fin de Grado El uso de las TIC mediante el aprendizaje cooperativo : atendiendo a la diversidad en Educación Primaria Marín Bernal, Sonia; Orta Vázquez, Manuel Luis (2015) Como educadores la primera cuestión que debemos plantearnos es qué es la Educación. Podemos definirla como la acción que ...
Artículo Effect of DNA repair deficiencies on the cytotoxicity of resveratrol López Lázaro, Miguel; Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago; López Lázaro, Miguel (2015) Numerous preclinical studies have shown that the naturally-occurring polyphenol resveratrol may produce health-beneficial ...
Artículo The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions Orta Vázquez, Manuel Luis; Calderón Montaño, José Manuel; Domínguez García, Inmaculada; Burgos Morón, Estefanía; Pastor Carrillo, Nuria María; López Lázaro, Miguel; Helleday, Thomas (Oxford University Press, 2014) Decitabine (5-aza-21-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid ...
Artículo Evaluating the cancer therapeutic potential of cardiac glycosides Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Orta Vázquez, Manuel Luis; Maldonado Navas, Dolores; García Domínguez, Irene; López Lázaro, Miguel (Hindawi Publishing Corporation, 2014) Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure ...
Artículo A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago; López Lázaro, Miguel (Georg Thieme Verlag, 2013) Recent evidence suggests that cardiac glycosides might be used for the treatment of cancer. The ornamental shrub Nerium ...
Artículo 5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair Orta Vázquez, Manuel Luis; Calderón Montaño, José Manuel; Domínguez García, Inmaculada; Pastor Carrillo, Nuria María; Burgos Morón, Estefanía; López Lázaro, Miguel; Cortés, Felipe; Mateos Cordero, Santiago; Helleday, Thomas (Oxford University Press, 2013) 5-Aza-2'-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological ...
Artículo Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation Groth, Petra; Orta Vázquez, Manuel Luis; Elvers, Ingegerd; Majumder, Muntasir Mamun; Lagerqvist, Anne; Helleday, Thomas (Oxford University Press, 2012) Ionizing radiation (IR) produces direct two-ended DNA double-strand breaks (DSBs) primarily repaired by non-homologous end ...
Artículo Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair Petermann, Eva; Orta Vázquez, Manuel Luis; Issaeva, Natalia; Schultz, Niklas; Helleday, Thomas (Elsevier, 2010) Faithful DNA replication is essential to all life. Hydroxyurea (HU) depletes the cells of dNTPs, which initially results ...