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Global dissemination of a multidrug resistant Escherichia coli clone

Opened Access Global dissemination of a multidrug resistant Escherichia coli clone


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Autor: Petty, Nicola K.
Ben Zakour, Nouri
Stanton-Cook, Mitchell
Skippington, Elizabeth
Totsika, Makrina
Forde, Brian M.
Phan, Minh-Duy
Gomes Moriel, Danilo
Peters, Kate M.
Davies, Mark
Rogers, Benjamin A.
Dougan, Gordon
Rodríguez-Baño, Jesús
Pascual Hernández, Álvaro
Pitout, Johann D. D.
Upton, Mathew
Paterson, David L.
Walsh, Timothy
Schembri, Mark
Beatson, Scott
Departamento: Universidad de Sevilla. Departamento de Medicina
Universidad de Sevilla. Departamento de Microbiología
Fecha: 2014-04
Publicado en: The Proceedings of the National Academy of Sciences of the United States of America, 111(15), 5694–5699
Tipo de documento: Artículo
Resumen: Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant (MDR) clone responsible for a high proportion of urinary tract and bloodstream infections. The rapid emergence and successful spread of E. coli ST131 is strongly associated with several factors, including resistance to fluoroquinolones, high virulence gene content, the possession of the type 1 fimbriae FimH30 allele, and the production of the CTX-M-15 extended spectrum β-lactamase (ESBL). Here, we used genome sequencing to examine the molecular epidemiology of a collection of E. coli ST131 strains isolated from six distinct geographical locations across the world spanning 2000–2011. The global phylogeny of E. coli ST131, determined from whole-genome sequence data, revealed a single lineage of E. coli ST131 distinct from other extraintestinal E. coli strains within the B2 phylogroup. Three closely related E. coli ST131 sublineages were identified, with little association to geographic origin. T...
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