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Impact of the MIC of Piperacillin-Tazobactam on the Outcome of Patients with Bacteremia Due to Extended-Spectrum-B-Lactamase- Producing Escherichia coli

 

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Opened Access Impact of the MIC of Piperacillin-Tazobactam on the Outcome of Patients with Bacteremia Due to Extended-Spectrum-B-Lactamase- Producing Escherichia coli
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Author: Retamar Gentil, Pilar
López Cerero, Lorena
Muniain Ezcurra, Miguel Angel
Pascual Hernández, Álvaro
Rodríguez-Baño, Jesús
Department: Universidad de Sevilla. Departamento de Medicina
Universidad de Sevilla. Departamento de Microbiología
Date: 2013-07
Published in: Antimicrobial Agents and Chemotherapy 57(7), 3402-3404
Document type: Article
Abstract: We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended- spectrum-B-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a MIC of <2 mg/liter than for isolates with a higher MIC (0% ver- sus 41.1%; P = 0.02)
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URI: http://hdl.handle.net/11441/39080

DOI: http://dx.doi.org/10.1128/AAC.00135-13

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