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Effect of Statin Therapy in the Outcome of Bloodstream Infections Due to Staphylococcus aureus: A Prospective Cohort Study

Opened Access Effect of Statin Therapy in the Outcome of Bloodstream Infections Due to Staphylococcus aureus: A Prospective Cohort Study

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Autor: López-Cortés, Luis E.
Gálvez-Acebal, Juan
Toro López, María Dolores del
Velasco Ramírez, María del Carmen
Cueto López, Marina
Caballero, Francisco J.
Muniain Ezcurra, Miguel Angel
Pascual Hernández, Álvaro
Rodríguez-Baño, Jesús
Departamento: Universidad de Sevilla. Departamento de Medicina
Universidad de Sevilla. Departamento de Microbiología
Fecha: 2013
Publicado en: PLoS ONE, 8 (12), e82958
Tipo de documento: Artículo
Resumen: Introduction: Statins have pleiotropic effects that could influence the prevention and outcome of some infectious diseases. There is no information about their specific effect on Staphylococcus aureus bacteremia (SAB). Methods: A prospective cohort study including all SAB diagnosed in patients aged $18 years admitted to a 950-bed tertiary hospital from March 2008 to January 2011 was performed. The main outcome variable was 14-day mortality, and the secondary outcome variables were 30-day mortality, persistent bacteremia (PB) and presence of severe sepsis or septic shock at diagnosis of SAB. The effect of statin therapy at the onset of SAB was studied by multivariate logistic regression and Cox regression analysis, including a propensity score for statin therapy. Results: We included 160 episodes. Thirty-three patients (21.3%) were receiving statins at the onset of SAB. 14-day mortality was 21.3%. After adjustment for age, Charlson index, Pitt score, adequate management, and hi...
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Tamaño: 223.2Kb
Formato: PDF

URI: http://hdl.handle.net/11441/33998

DOI: 10.1371/journal.pone.0082958

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