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dc.creatorGao Chen, Lin
dc.creatorHidalgo-Figueroa, María
dc.creatorEscudero Cuadrado, Luis María
dc.creatorDíaz Martín, Juan
dc.creatorLópez Barneo, José
dc.creatorPascual Bravo, Alberto
dc.date.accessioned2015-01-14T13:52:18Z
dc.date.available2015-01-14T13:52:18Z
dc.date.issued2013
dc.identifier.issn1932-6203es
dc.identifier.urihttp://hdl.handle.net/11441/17475
dc.description.abstractSubstantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson’s disease (PD). Until now, molecular mechanisms behind SNpc aging have not been fully investigated using high throughput techniques. Here, we show early signs of aging in SNpc, which are more evident than in ventral tegmental area (VTA), a region adjacent to SNpc but less affected in PD. Aging-associated early changes in transcriptome were investigated comparing late middle-aged (18 months old) to young (2 months old) mice in both SNpc and VTA. A meta-analysis of published microarray studies allowed us to generate a common ‘‘transcriptional signature’’ of the aged ($ 24 months old) mouse brain. SNpc of late-middle aged mice shared characteristics with the transcriptional signature, suggesting an accelerated aging in SNpc. Age-dependent changes in gene expression specific to SNpc were also observed, which were related to neuronal functions and inflammation. Future studies could greatly help determine the contribution of these changes to SNpc aging. These data help understand the processes underlying SNpc aging and their potential contribution to age-related disorders like PD.es
dc.language.isoenges
dc.relation.ispartofPLoS One, 8 (4), 1-12.es
dc.rightsAtribución-NoComercial-SinDerivadas 4.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleAge-mediated transcriptomic changes in adult mouse substantia nigraes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Biología Celulares
dc.journaltitlePLoS Onees
dc.publication.volumen8es
dc.publication.issue4es
dc.publication.initialPage1es
dc.publication.endPage12es
dc.identifier.idushttps://idus.us.es/xmlui/handle/11441/17475

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