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Listar Artículos (Química Orgánica) por autor "Carmona Asenjo, Ana Teresa"
Mostrando ítems 1-20 de 20
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Artículo
Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry
Elías Rodríguez, María del Pilar; Pingitore, Valeria; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Ide, Daisuke; Miyawaki, Shota; Kato, Atsushi; Álvarez González, Eleuterio; Robina Ramírez, Inmaculada (American Chemical Society, 2018)The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in ...
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Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars
Pingitore, Valeria; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Mészáros, Zuzana; Kulik, Natalia; Slámová, Kristýna; Křen, Vladimír; Bojarová, Pavla; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José (Elsevier, 2022)Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ...
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Experimental and Theoretical Analysis of the Thiol-Promoted Fragmentation of 2-Halo-3-tosyl-oxanorbornadienes
Carranza César, Marina; Carmona Asenjo, Ana Teresa; Navo, Claudio D.; Robina Ramírez, Inmaculada; Fratta, Simone; Newburn, Carlos; Jimenez-Oses, Gonzalo; Moreno Vargas, Antonio José (American Chemical Society, 2023)2-Halo-3-tosyl-oxanorbornadienes are able to accept two thiol molecules through an initial nucleophilic substitution, ...
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Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B
Monaco, Serena; Walpole, Samuel; Doukani, Hassan; Nepravishta, Ridvan; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Ramos Soriano, Francisco Javier; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Wiley, 2020)Ligand-based NMRtechniquesto studyprotein–ligandinteractionsare potenttoolsin drugdesign.Satura-tiontransfer difference ...
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Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines
Elías Rodríguez, María del Pilar; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Robina Ramírez, Inmaculada (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Iminosugar derivatives containing a pyrrolidine-phosphine moiety were prepared from carbohydrates and used as catalysts ...
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Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket
Monaco, Serena; Ramírez Cárdenas, Jonathan; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Multidisciplinary Digital Publishing Institute (MDPI), 2022)In recent years, Saturation Transfer Difference NMR (STD NMR) has been proven to be a powerful and versatile ligand-based ...
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Monosaccharides and Analogues from Simple Achiral Unsaturated Compounds
Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Moreno Clavijo, Elena; Robina Ramírez, Inmaculada (Schweizerische Chemische Gesellschaft, 2011)We present herein a selection of ingenious methods that have been developed to convert inexpensive furan, pyrrole and unsaturated hydrocarbons into enantiomerically enriched monosaccharides and analogues of biological interest.
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Preparation of water-soluble glycopolymers derived from five-membered iminosugars
Martínez Bailen, Macarena; Galbis Fuster, Elsa; Carmona Asenjo, Ana Teresa; Paz Báñez, María Violante de; Robina Ramírez, Inmaculada (Elsevier, 2019-10)Iminosugars are carbohydrate mimetics that constitute the main group of oligosaccharide processing enzyme inhibitors. ...
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Stereoselective synthesis of chiral furan amino acid analogues of D- and L-serine from D-sugars
Molina, Lidia; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada (Georg Thieme Verlag, 2006)The synthesis of chiral furan amino acid analogues of D - and L -serine is reported. The developed methodology ...
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Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars
Martínez Bailén, Macarena; Jiménez Ortega, Elena; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Sanz Aparicio, Julia; Talens Perales, David; Polaina, Julio; Matassini, Camilla; Cardona, Francesca; Moreno Vargas, Antonio José (Elsevier, 2019)The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives ...
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Studies on the Regioselective Rearrangement of Azanorbornanic Aminyl Radicals into 2,8-Diazabicyclo[3.2.1]oct-2-ene Systems
Gil de Montes Rojas, Enrique; Tallarida, Matteo A.; Carmona Asenjo, Ana Teresa; Navo, Claudio D.; Robina Ramírez, Inmaculada; Elías Rodríguez, María del Pilar; Jiménez Oses, Gonzalo; Moreno Vargas, Antonio José (American Chemical Society, 2022)Aminyl radicals are nitrogen-centered radicals of interest in synthetic strategies involving C–N bond formation due to ...
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Syntheses and biological activities of 1,4-iminoalditol derivatives as α-L-fucosidase inhibitors
Moreno Clavijo, Elena; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Molina Sanz, Lidia; Robina Ramírez, Inmaculada (Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011)A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of α-l-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented.
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Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers
Coste, G.; Horlacher, T.; Molina Sanz, Lidia; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Seeberger, P.H.; Gerber-Lemaire, S. (Thieme Publishing; Georg Thieme Verlag, 2011)Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for ...
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Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives
Elías Rodríguez, María del Pilar; Moreno Clavijo, Elena; Carrión Jiménez, Sebastián; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Caffa, I.; Montecucco, F.; Cea, M.; Nencioni, A.; Robina Ramírez, Inmaculada (Arkat USA, 2014)A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for ...
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Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer
Fratta, Simone; Biniecka, Paulina; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Nahimana, Aimable; Duchosal, Michel A.; Piacente, Francesco; Bruzzone, Santina; Caffa, Irene; Nencioni, Alessio; Robina Ramírez, Inmaculada (Elsevier, 2023)Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for proliferation, therefore ...
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Synthesis of Novel 3-Amino(Hydroxy)methyl-l-fuco-Azafagomines as Leads for Selective Inhibitors of α-l-Fucosidases
Moreno Clavijo, Elena; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Álvarez González, Eleuterio; Robina Ramírez, Inmaculada (2010)The synthesis of 3-substituted l-fuco-azafagomines from d-lyxose is reported. They represent the first example of ...
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Synthesis of tri- and tetramines containing two 2,3-dihydroxypyrrolidine moieties and their inhibitory activity toward α-mannosidases
Gerber-Lemaire, S.; Popowycz, Florence; Rodríguez García, Eliazar; Schütz, Catherine; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Vogel, Pierre (Arkat USA, 2002)Through the reductive amination of N-[(tert-butoxy)carbonyl]-2,5-dideoxy-2, 5-imino-3,4-O-isopropylidene-L-ribose with ...
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Artículo
Synthesis of tri- and tetramines containing two 2,3-dihydroxypyrrolidine moieties and their inhibitory activity toward α-mannosidases
Gerber-Lemaire, S.; Popowycz, Florence; Rodriguez García, Eliazar; Schütz, Catherine; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Vogel, Pierre (ARKAT USA INC, 2002)Through the reductive amination of N-[(tert-butoxy)carbonyl]-2,5-dideoxy-2,5-imino-3,4-Oisopropylidene-L-ribose with ...
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Total asymmetric synthesis of monosaccharides and analogues
Robina Ramírez, Inmaculada; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Moreno Clavijo, Elena (Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011)Since the discovery of the 'formose reaction' by Butlerow,[1] total synthesis of carbohydrates has undergone rapid ...
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Artículo
Transferring Substituents from Alkynes to Furans and Pyrroles through Heteronorbornadienes as Intermediates: Synthesis of β-Substituted Pyrroles/Furans
García Domínguez, Javier; Carranza César, Marina; Jansons, Edijs; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José (American Chemical Society, 2023)The use of 7-oxa/azanorbornadienes as synthetic intermediates for the preparation of 3/4-substituted (β-substituted) ...