NameCarmona Asenjo, Ana Teresa
DepartmentQuímica Orgánica
Knowledge areaQuímica Orgánica
Professional categoryProfesora Titular de Universidad
E-mailRequest
           
  • No. publications

    27

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PhD Thesis
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Synthesis of new nampt inhibitors as potential anti-cancer drugs. An approach to antibody-drug conjugates

Fratta, Simone; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Robina Ramírez, Inmaculada (2023)
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in the biosynthesis of Nicotinamide Adenine ...
Article
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Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer

Fratta, Simone; Biniecka, Paulina; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Nahimana, Aimable; Duchosal, Michel A.; Piacente, Francesco; Bruzzone, Santina; Caffa, Irene; Nencioni, Alessio; Robina Ramírez, Inmaculada (Elsevier, 2023)
Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for proliferation, therefore ...
Article
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Transferring Substituents from Alkynes to Furans and Pyrroles through Heteronorbornadienes as Intermediates: Synthesis of β-Substituted Pyrroles/Furans

García Domínguez, Javier; Carranza César, Marina; Jansons, Edijs; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José (American Chemical Society, 2023)
The use of 7-oxa/azanorbornadienes as synthetic intermediates for the preparation of 3/4-substituted (β-substituted) ...
Article
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Experimental and Theoretical Analysis of the Thiol-Promoted Fragmentation of 2-Halo-3-tosyl-oxanorbornadienes

Carranza César, Marina; Carmona Asenjo, Ana Teresa; Navo, Claudio D.; Robina Ramírez, Inmaculada; Fratta, Simone; Newburn, Carlos; Jimenez-Oses, Gonzalo; Moreno Vargas, Antonio José (American Chemical Society, 2023)
2-Halo-3-tosyl-oxanorbornadienes are able to accept two thiol molecules through an initial nucleophilic substitution, ...
Article
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Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket

Monaco, Serena; Ramírez Cárdenas, Jonathan; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Multidisciplinary Digital Publishing Institute (MDPI), 2022)
In recent years, Saturation Transfer Difference NMR (STD NMR) has been proven to be a powerful and versatile ligand-based ...
Article
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Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars

Pingitore, Valeria; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Mészáros, Zuzana; Kulik, Natalia; Slámová, Kristýna; Křen, Vladimír; Bojarová, Pavla; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José (Elsevier, 2022)
Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ...
Article
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Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines

Elías Rodríguez, María del Pilar; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Robina Ramírez, Inmaculada (Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Iminosugar derivatives containing a pyrrolidine-phosphine moiety were prepared from carbohydrates and used as catalysts ...
PhD Thesis
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Reacciones Clic y evaluación in situ para la identificación de inhibidores de glicosidasas

Pingitore, Valeria; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa (2021)
Los iminoazúcares constituyen la categoría más importante de inhibidores de glicosidasas, sin embargo, su escasa selectividad ...
Article
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Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B

Monaco, Serena; Walpole, Samuel; Doukani, Hassan; Nepravishta, Ridvan; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Ramos Soriano, Francisco Javier; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Wiley, 2020)
Ligand-based NMRtechniquesto studyprotein–ligandinteractionsare potenttoolsin drugdesign.Satura-tiontransfer difference ...
Article
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Preparation of water-soluble glycopolymers derived from five-membered iminosugars

Martínez Bailen, Macarena; Galbis Fuster, Elsa; Carmona Asenjo, Ana Teresa; Paz Báñez, María Violante de; Robina Ramírez, Inmaculada (Elsevier, 2019)
Iminosugars are carbohydrate mimetics that constitute the main group of oligosaccharide processing enzyme inhibitors. They ...
PhD Thesis
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Diseño y síntesis de derivados mono- y multivalentes de 1,4-iminociclitoles: estudio de sus propiedades como inhibidores de glicosidasas.

Martínez Bailen, Macarena; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Robina Ramírez, Inmaculada (2019)
Article
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Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars

Martínez Bailén, Macarena; Jiménez Ortega, Elena; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Sanz Aparicio, Julia; Talens Perales, David; Polaina, Julio; Matassini, Camilla; Cardona, Francesca; Moreno Vargas, Antonio José (Elsevier, 2019)
The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives ...
Article
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Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry

Elías Rodríguez, María del Pilar; Pingitore, Valeria; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Ide, Daisuke; Miyawaki, Shota; Kato, Atsushi; Álvarez González, Eleuterio; Robina Ramírez, Inmaculada (American Chemical Society, 2018)
The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in ...
PhD Thesis
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Preparación, aplicaciones y reactividad de nuevos derivados de iminoazúcares. Síntesis de análogos del FK866 con propiedades anticáncer

Elías Rodríguez, María del Pilar; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Robina Ramírez, Inmaculada (2017)
En esta Tesis Doctoral se ha desarrollado la síntesis de nuevos (pirrolidín-2-il)-Ctriazoles con configuración L-fuco ...
Article
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Host-guest interactions between cyclodextrins and surfactants with functional groups at the end of the hydrophobic tail

Martín, Victoria I.; Ostos Marcos, Francisco José; Angulo Álvarez, Manuel; Márquez Cruz, Antonio Marcial; López-Cornejo, María del Pilar; López López, Manuel; Carmona Asenjo, Ana Teresa; Moyá Morán, María Luisa (Elsevier, 2017)
The aim of this work was to investigate the influence of the incorporation of substituents at the end of the hydrophobic ...
Article
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Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives

Elías Rodríguez, María del Pilar; Moreno Clavijo, Elena; Carrión Jiménez, Sebastián; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Caffa, I.; Montecucco, F.; Cea, M.; Nencioni, A.; Robina Ramírez, Inmaculada (Arkat USA, 2014)
A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for ...
Article
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Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers

Coste, G.; Horlacher, T.; Molina Sanz, Lidia; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Seeberger, P.H.; Gerber-Lemaire, S. (Thieme Publishing; Georg Thieme Verlag, 2011)
Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for ...
Article
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Syntheses and biological activities of 1,4-iminoalditol derivatives as α-L-fucosidase inhibitors

Moreno Clavijo, Elena; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Molina Sanz, Lidia; Robina Ramírez, Inmaculada (Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011)
A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of α-l-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented.
Article
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Total asymmetric synthesis of monosaccharides and analogues

Robina Ramírez, Inmaculada; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Moreno Clavijo, Elena (Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011)
Since the discovery of the 'formose reaction' by Butlerow,[1] total synthesis of carbohydrates has undergone rapid ...
Article
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Monosaccharides and Analogues from Simple Achiral Unsaturated Compounds

Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Moreno Clavijo, Elena; Robina Ramírez, Inmaculada (Schweizerische Chemische Gesellschaft, 2011)
We present herein a selection of ingenious methods that have been developed to convert inexpensive furan, pyrrole and unsaturated hydrocarbons into enantiomerically enriched monosaccharides and analogues of biological interest.
Patent. Invention
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Tiofucósidos conteniendo prolinas hidroxiladas, síntesis y usos de los mismos

Moreno Vargas, Antonio José; Molina Sanz, Lidia; Carmona Asenjo, Ana Teresa; Lambelet, Martine; Spertini, Oliver; Robina Ramírez, Inmaculada (Oficina Española de Patentes y Marcas (OEPM), 2010)
Tiofucósidos conteniendo prolinas hidroxiladas, síntesis y usos de los mismos. Compuesto que comprende un tiofucósido ...
Patent. Invention
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Tiofucósidos conteniendo polihidroxialquil-furanos, síntesis y usos de los mismos

Moreno Vargas, Antonio José; Molina Sanz, Lidia; Carmona Asenjo, Ana Teresa; Lambelet, Martine; Spertini, Olivier; Robina Ramírez, Inmaculada (Oficina Española de Patentes y Marcas (OEPM), 2010)
Tiofucósidos conteniendo polihidroxialquil-furanos, síntesis y usos de los mismos. Compuesto que comprende un tiofucósido ...
Article
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Synthesis of Novel 3-Amino(Hydroxy)methyl-l-fuco-Azafagomines as Leads for Selective Inhibitors of α-l-Fucosidases

Moreno Clavijo, Elena; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Álvarez González, Eleuterio; Robina Ramírez, Inmaculada (2010)
The synthesis of 3-substituted l-fuco-azafagomines from d-lyxose is reported. They represent the first example of ...
PhD Thesis
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Síntesis estereoselectiva de nuevos furil-aminoácidos y su uso en la preparación de plataformas moleculares y de ligando de biomoléculas

Molina Sanz, Lidia; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa (2009)
Los polihidroxialquil-heterociclos son intermedios sintéticos muy interesantes para la preparación de productos de interés ...
Article
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Stereoselective synthesis of chiral furan amino acid analogues of D- and L-serine from D-sugars

Molina, Lidia; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada (Georg Thieme Verlag, 2006)
The synthesis of chiral furan amino acid analogues of D - and L -serine is reported. The developed methodology starting ...
Article
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Synthesis of tri- and tetramines containing two 2,3-dihydroxypyrrolidine moieties and their inhibitory activity toward α-mannosidases

Gerber-Lemaire, S.; Popowycz, Florence; Rodríguez García, Eliazar; Schütz, Catherine; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Vogel, Pierre (Arkat USA, 2002)
Through the reductive amination of N-[(tert-butoxy)carbonyl]-2,5-dideoxy-2, 5-imino-3,4-O-isopropylidene-L-ribose with ...
Article
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Synthesis of tri- and tetramines containing two 2,3-dihydroxypyrrolidine moieties and their inhibitory activity toward α-mannosidases

Gerber-Lemaire, S.; Popowycz, Florence; Rodriguez García, Eliazar; Schütz, Catherine; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Vogel, Pierre (ARKAT USA INC, 2002)
Through the reductive amination of N-[(tert-butoxy)carbonyl]-2,5-dideoxy-2,5-imino-3,4-Oisopropylidene-L-ribose with ...