- idUS
- Investigación
- Ciencias
- Química Orgánica
- Artículos (Química Orgánica)
- Listar Artículos (Química Orgánica) por autor
Listar Artículos (Química Orgánica) por autor "Ortiz Mellet, Carmen"
Mostrando ítems 21-40 de 54
-
Artículo
Inhibition of Type 1 Fimbriae-mediated Escherichia Coli Adhesion and Biofilm Formation by Trimeric Cluster Thiomannosides Conjugated to Diamond Nanoparticles
Khanal, Manakamana; Larsonneur, Fanny; Raks, Victoriia; Barras, Alexandre; Baumann, Jean-Sébastien; Martin, Fernando Ariel; Martin, Fernando Ariel; Boukherroub, Rabah; Ghigo, Jean Marc; Ortiz Mellet, Carmen; Zaitsev, Vladimir; Garcia Fernandez, Jose M.; Beloin, Christophe; Siriwardena, Aloysius; Szunerits, Sabine (Royal Society of Chemistry, 2015)Recent advances in nanotechnology have seen the development of a number of microbiocidal and/or anti-adhesive nanoparticles ...
-
Artículo
Insights in Cellular Uptake Mechanisms of pDNA-polycationic Amphiphilic Cyclodextrin Nanoparticles (CDplexes)
Díaz Moscoso, Alejandro; Vercauteren, Dries; Rejman, Joanna; Benito, Juan M.; Ortiz Mellet, Carmen; De Smedt, Stefaan C.; Fernández, José M. García (Elsevier, 2010)It is generally recognized that the major obstacle to efficient gene delivery is cellular internalization and endosomal ...
-
Artículo
Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery
Díaz Moscoso, Alejandro; Guilloteau, Nicolas; Bienvenu, Céline; Méndez Ardoy, Alejandro; Jiménez Blanco, José Luis; Benito Hernández, Juan Manuel; Le Gourriérec, Loïc; Di Giorgio, Christophe; Vierling, Pierre; Defaye, Jacques; Ortiz Mellet, Carmen; García Fernández, José Manuel (Elsevier, 2011-10)Fully homogeneous facial amphiphiles consisting in a cyclodextrin (CD) platform onto which a polycationic cluster and a ...
-
Artículo
Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection
Manzanares, Darío; Araya Durán, Ingrid; Gallego Yerga, Laura; Játiva, Pablo; Márquez Miranda, Valeria; Canan, Jonathan; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; González Nilo, Fernando Danilo; García Fernández, José Manuel; Ceña, Valentín (Future Medicine Ltd., 2017)Aim: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient ...
-
Artículo
Multiply–linked cyclodextrin–aromatic hybrids: Caps, hinges and clips
Neva, Tania; Ortiz Mellet, Carmen; Fernández, José M. García; Benito, Juan M. (Taylor & Francis, 2019)The judicious combination of shaping and recognition elements in cage-type architectures represents a powerful strategy ...
-
Artículo
Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators
González Cuesta, Manuel; Goyard, David; Nanba, Eiji; Higaki, Katsumi; García Fernández, José Manuel; Renaudet, Olivier; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2019)Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide ...
-
Artículo
New Castanospermine Glycoside Analogues Inhibit Breast Cancer Cell Proliferation and Induce Apoptosis without Affecting Normal Cells
Allan, Ghada; Ouadid-Ahidouch, Halima; Sánchez Fernández, Elena Matilde; Risquez Cuadrado, Rocío; García Fernández, José Manuel; Ortiz Mellet, Carmen; Ahidouch, Ahmed (Public Library of Science, 2013)sp2-Iminosugar-type castanospermine analogues have been shown to exhibit anti-tumor activity. However, their effects on ...
-
Artículo
Novel Therapies for Orphan Diseases
García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2019)"Orphan" does not mean infrequent: over 7000 rare diseases affect millions of individuals. The US Orphan Drug Act and ...
-
Artículo
Pharmacological chaperone therapy for Gaucher disease: A patent review
Benito, Juan Manuel; García Fernández, José Manuel; Ortiz Mellet, Carmen (Taylor & Francis, 2011)Introduction: Mutations in the gene encoding for acid β-glucosidase (β-glucocerebrosidase, GlcCerase) are seen in Gaucher ...
-
Artículo
Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease
Mata, Mario de la; Cotán, David; Oropesa Ávila, Manuel; Garrido Maraver, Juan; Cordero Morales, Mario David; Ortiz Mellet, Carmen; Ybot González, Patricia; García Fernández, José Manuel (Nature Publishing Group, 2015)Gaucher disease (GD) is caused by mutations in the GBA1 gene, which encodes lysosomal β-glucocerebrosidase. Homozygosity ...
-
Artículo
Pharmacological Chaperones for the Treatment of α-Mannosidosis
Rísquez Cuadro, Rocío; Matsumoto, Reimi; Ortega Caballero, Fernando; Nanba, Eiji; Higaki, Katsumi; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2019)α-Mannosidosis (AM) results from deficient lysosomal α-mannosidase (LAMAN) activity and subsequent substrate accumulation ...
-
Artículo
Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieteres, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (Molecular Diversity Preservation International, 2018)A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
-
Artículo
Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieters, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (MDPI, 2021)A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
-
Artículo
(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties
Jiménez Blanco, José Luis; Ortega Caballero, Fernando; Ortiz Mellet, Carmen; García Fernández, José Manuel (Beilstein-Institut, 2010)Oligosaccharides are currently recognised as having functions that influence the entire spectrum of cell activities. ...
-
Artículo
Reversible Light-Induced Dimerization of Secondary Face Azobenzene-Functionalized β-Cyclodextrin Derivatives
Rivero Barbarroja, Gonzalo; Fernández Clavero, C.; García Iriepa, C.; Marcelo, G.; Padilla Pérez, María del Carmen; Neva, T.; Benito, J. M.; Maisonneuve, S.; Ortiz Mellet, Carmen; Xie, J.; García Fernández, J. M.; Mendicuti, F. (American Chemical Society, 2023)β-cyclodextrin (βCyD) derivatives equipped with aromatic appendages at the secondary face exhibit tailorable self-assembling ...
-
Artículo
Serine-/Cysteine-based sp2-Iminoglycolipids as novel TLR4 agonists: evaluation of their adjuvancy and immunotherapeutic properties in a murine model of asthma
González Cuesta, Manuel; Lai, Alan Chuan Ying; Chi, Po Yu; Hsu, I. Ling; Liu, Nien Tzu; Wu, Ko Chien; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2023)Glycolipids with TLR4 agonistic properties can serve either as therapeutic agents or as vaccine adjuvants by stimulating ...
-
Artículo
sp2-Iminosugar Glycolipids as Inhibitors of Lipopolysaccharide-mediated Human Dendritic Cell Activation in Vitro and of Acute Inflammation in Mice in Vivo
Schaeffer, Evelyne; Sánchez Fernández, Elena Matilde; Gonçalves-Pereira, Rita; Flacher, Vincent; Lamon, Delphine; Duval, Monique; Fauny, Jean Daniel; García Fernández, José Manuel; Mueller, Christopher G.; Ortiz Mellet, Carmen (Elsevier, 219)Glycolipid mimetics consisting of a bicyclic polyhydroxypiperidine-cyclic carbamate core and a pseudoanomeric hydrophobic ...
-
Artículo
sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
González Cuesta, Manuel; Herrera González, Irene; García Moreno, M. Isabel; Ashmus, Roger A.; Vocadlo, David J.; García Fernández, José Manuel; Nanba, Eiji; Higaki, Katsumi; Ortiz Mellet, Carmen (Taylor & Francis, 2022)The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below ...
-
Artículo
Spacer-mediated synthesis of bis-spiroketal disaccharides: Nonsymmetrical furanose-pyranose difructose dianhydrides
Louis, Farida F.; García Moreno, M. Isabel; Balbuena Oliva, Patricia; Ortiz Mellet, Carmen; García Fernández, José Manuel (2007)The stereochemical outcome of the dimerization reaction of D-fructose, leading to tricyclic bis-spiroketal systems, can ...
-
Artículo
Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors
Fuente, Alex de la; Mena Barragán, Teresa; Farrar-Tobar, Ronald A.; Verdaguer, Xavier; García Fernández, José Manuel; Ortiz Mellet, Carmen; Riera, Antoni (Royal Society of Chemistry, 2015)2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic ...