Artículos (Química Orgánica)
Envíos recientes
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Organocatalysis and Biocatalysis Hand in Hand: Combining Catalysts in One-Pot Procedures
(Wiley, 2017)Multi-step processes catalysed by several catalysts working concurrently have been developed in nature, thus improving ...
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Tacrine-sugar mimetic conjugates as enhanced cholinesterase inhibitors
(Royal Society of Chemistry, 2021-03-14)We have used the Cu(i)-catalyzed azide-alkyne Huisgen cycloaddition reaction to obtain two families of bivalent heterodimers ...
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Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations
(Elsevier, 2019-10-01)Herein we report a straightforward preparation of new antiproliferative agents based on the hybridization of a coumarin ...
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Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs
(Elsevier, 2018-01-01)Herein we report the straightforward preparation of novel conformationally-restricted steroids from trans-androsterone and ...
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Biotinylated selenocyanates: Potent and selective cytostatic agents
(Elsevier, 2023-04)Most of the currently available cytotoxic agents for tackling cancer are devoid of selectivity, thus causing severe ...
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Cyclopentyl Methyl Ether (CPME): A Versatile Eco-Friendly Solvent for Applications in Biotechnology and Biorefineries
(Wiley, 2019-05)The quest for sustainable solvents is currently a matter of intense research and development, as solvents significantly ...
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Chemoenzymatic Dynamic Kinetic Resolution of Primary Benzylic Amines using Pd0-CalB CLEA as a Biohybrid Catalyst
(Wiley, 2019-07-11)Herein, we report on the use a biohybrid catalyst consisting of palladium nanoparticles immobilized on cross-linked enzyme ...
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Biocatalytic Atroposelective Synthesis of Axially Chiral N-Arylindoles via Dynamic Kinetic Resolution
(American Chemical Society, 2022-12-22)A highly enantioselective biocatalytic dynamic kinetic resolution (DKR) of configurationally labile N-arylindole aldehydes ...
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N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study
(Elsevier, 2020-05)Our goal was the evaluation of a series of N-1,2,3-triazole-isatin derivatives for multi-target activity which included ...
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Chemoenzymatic synthesis and radical scavenging of sulfated hydroxytyrosol, tyrosol, and acetylated derivatives
(American Chemical Society, 2019-07-03)Potential metabolites of bioactive compounds are important for their biological activities and as authentic standards for ...
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Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors
(Elsevier, 2019-11-01)Concerned by the devastating effects of Alzheimer's disease, and the lack of effective drugs, we have carried out the ...
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Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease
(Elsevier, 2022-10)Concerned by the urgent need to explore new approaches for the treatment of Alzheimer's disease, we herein describe the ...
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Preparation of water-soluble glycopolymers derived from five-membered iminosugars
(Elsevier, 2019-10)Iminosugars are carbohydrate mimetics that constitute the main group of oligosaccharide processing enzyme inhibitors. ...
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A Complex Regulatory Network Governs the Expression of Symbiotic Genes in Sinorhizobium Fredii HH103
(Frontiers Media, 2023)Introduction: The establishment of the rhizobium-legume nitrogen-fixing symbiosis relies on the interchange of molecular ...
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Experimental and Theoretical Analysis of the Thiol-Promoted Fragmentation of 2-Halo-3-tosyl-oxanorbornadienes
(American Chemical Society, 2023)2-Halo-3-tosyl-oxanorbornadienes are able to accept two thiol molecules through an initial nucleophilic substitution, ...
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Reversible Light-Induced Dimerization of Secondary Face Azobenzene-Functionalized β-Cyclodextrin Derivatives
(American Chemical Society, 2023)β-cyclodextrin (βCyD) derivatives equipped with aromatic appendages at the secondary face exhibit tailorable self-assembling ...
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Transferring Substituents from Alkynes to Furans and Pyrroles through Heteronorbornadienes as Intermediates: Synthesis of β-Substituted Pyrroles/Furans
(American Chemical Society, 2023)The use of 7-oxa/azanorbornadienes as synthetic intermediates for the preparation of 3/4-substituted (β-substituted) ...
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Investigation of the Enantioselectivity of Acetylcholinesterase and Butyrylcholinesterase upon Inhibition by Tacrine-iminosugar Heterodimers
(Taylor & Francis, 2023)The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing ...
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Emerging Strategies to Improve the Design and Manufacturing of Biocompatible Therapeutic Materials
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)Currently, the field of medicine is drastically advancing, mainly due to the progress in emerging areas such as nanomedicine, ...
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Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the development of new inhibitors of ...