Artículo
Pd(II)-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic N-Carbamoyl Hydrazones
Autor/es | Alberca Manzano, Saúl
Velázquez Muñoz, Marta Trujillo Sierra, José Iglesias Sigüenza, Francisco Javier Fernández Fernández, Rosario Fátima Lassaletta, José M. Monge Fernández, David |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2022 |
Fecha de depósito | 2024-08-30 |
Publicado en |
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Resumen | Catalysts generated by combinations of Pd(TFA)2 and pyridine-hydrazone ligands have been
applied to 1,2 addition of arylboronic acids to aliphatic N-carbamoyl (Cbz) hydrazones, affording protected α-
aryl monoalkylhydrazines ... Catalysts generated by combinations of Pd(TFA)2 and pyridine-hydrazone ligands have been applied to 1,2 addition of arylboronic acids to aliphatic N-carbamoyl (Cbz) hydrazones, affording protected α- aryl monoalkylhydrazines with high enantioselectivities (37-99% ee). Subsequent removal of the benzyloxy carbonyl protecting group provides a direct entry to free monosubstituted hydrazines, key building blocks for the synthesis of appealing 1,2-diaza-heterocycles, aminoacid derived hydrazides and other pharmacophores thereof. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España Junta de Andalucía |
Identificador del proyecto | CTQ2016-76908-C2-1-PCTQ2016-76908-C2-2-P
P18-FR-3531 P18-FR-644 |
Cita | Alberca Manzano, S., Velázquez Muñoz, M., Trujillo Sierra, J., Iglesias Sigüenza, F.J., Fernández Fernández, R.F., Lassaletta, J.M. y Monge Fernández, D. (2022). Pd(II)-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic N-Carbamoyl Hydrazones. Cover Image Advanced Synthesis & Catalysis, 364 (14), 2373-2379. https://doi.org/10.1002/adsc.202200430. |
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