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Artículo
Multienzymatic processes involving baeyer–villiger monooxygenases
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Baeyer–Villiger monooxygenases (BVMOs) are flavin-dependent oxidative enzymes capable of catalyzing the insertion of an oxygen atom between a carbonylic Csp2 and the Csp3 at the alpha position, therefore transforming linear ...
Artículo
Positive impact of natural deep eutectic solvents on the biocatalytic performance of 5-hydroxymethyl-furfural oxidase
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Deep eutectic solvents (DESs) have been applied as cosolvents in various biocatalytic processes during recent years. However, their use in combination with redox enzymes has been limited. In this study, we have explored ...
Artículo
Polycyclic Ketone Monooxygenase (PockeMO): A Robust Biocatalyst for the Synthesis of Optically Active Sulfoxides
(Multidisciplinary Digital Publishing Institute (MDPI), 2017)
recently discovered, moderately thermostable Baeyer-Villiger monooxygenase, polycyclic ketone monooxygenase (PockeMO), from Thermothelomyces thermophila has been employed as a biocatalyst in a set of asymmetric sulfoxidations. ...
Artículo
P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules
(MDPI, 2019)
A set of dual functional small molecules (DFSMs) containing different amino acids has been synthesized and employed together with three different variants of the cytochrome P450 monooxygenase P450BM3 from Bacillus ...
Artículo
Recent developments in the synthesis of β-diketones
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Apart from being one of the most important intermediates in chemical synthesis, broadly used in the formation of C–C bonds among other processes, the β-dicarbonyl structure is present in a huge number of biologically and ...
Artículo
Deracemisation Processes Employing Organocatalysis and Enzyme Catalysis
(Wiley-Blackwell, 2020)
Deracemisation methods have demonstrated their importance in the preparation of chiral compounds in the last few years. In order to resolve a racemic mixture in a dynamic sense, one enantiomer of the starting material can ...
Artículo
Lipase catalysed kinetic resolution of racemic 1,2-diols containing a chiral quaternary center
(MDPI, 2018)
Optically active 1,2-diols are valuable buildings blocks in organic synthesis. In the present paper, a set of racemic 1,2-diols with an ester functional group are prepared, starting from -ketoesters in a three-step ...
Artículo
Application of Biobased Solvents in Asymmetric Catalysis
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
The necessity of more sustainable conditions that follow the twelve principles of Green Chemistry have pushed researchers to the development of novel reagents, catalysts and solvents for greener asymmetric methodologies. ...
Artículo
Biocatalyzed redox processes employing green reaction media
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
The application of biocatalysts to perform reductive/oxidative chemical processes has attracted great interest in recent years, due to their environmentally friendly conditions combined with high selectivities. In some ...