Histone deacetylases facilitate the accurate repair of broken forks

Gómez González, Belén; Ortega Moreno, Pedro; Aguilera López, Andrés

doi:10.1080/23723556.2019.1705731

Artículo

dc.creator	Gómez González, Belén	es
dc.creator	Ortega Moreno, Pedro	es
dc.creator	Aguilera López, Andrés	es
dc.date.accessioned	2020-06-30T17:09:36Z
dc.date.available	2020-06-30T17:09:36Z
dc.date.issued	2020
dc.identifier.citation	Gómez González, B., Ortega Moreno, P. y Aguilera López, A. (2020). Histone deacetylases facilitate the accurate repair of broken forks. Molecular and Cellular Oncology, 7 (2), 1705731.
dc.identifier.issn	2372-3556	es
dc.identifier.uri	https://hdl.handle.net/11441/98548
dc.description.abstract	We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA damage at replication forks and enhancing genetic instability. Here we discuss the possible implications of our findings given that histone deacetylases are a promising chemotherapeutic target often used in combination with DNA damaging agents.	es
dc.format	application/pdf	es
dc.format.extent	5 p.	es
dc.language.iso	eng	es
dc.publisher	Taylor & Francis	es
dc.relation.ispartof	Molecular and Cellular Oncology, 7 (2), 1705731.
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Cohesion	es
dc.subject	Double-strand break repair	es
dc.subject	Histone deacetylase inhibitors	es
dc.subject	Histone deacetylases	es
dc.subject	Sister-chromatid recombination	es
dc.title	Histone deacetylases facilitate the accurate repair of broken forks	es
dc.type	info:eu-repo/semantics/article	es
dcterms.identifier	https://ror.org/03yxnpp24
dc.type.version	info:eu-repo/semantics/submittedVersion	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es
dc.contributor.affiliation	Universidad de Sevilla. Departamento de Genética	es
dc.relation.publisherversion	http://dx.doi.org/10.1080/23723556.2019.1705731	es
dc.identifier.doi	10.1080/23723556.2019.1705731	es
dc.journaltitle	Molecular and Cellular Oncology	es
dc.publication.volumen	7	es
dc.publication.issue	2	es
dc.publication.initialPage	1705731	es

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